DOI: 10.1055/s-00035024

Thrombosis and Haemostasis

Issue 10 · Volume 100 · 2008 DOI: 10.1055/s-008-36081

Editorial Focus

517
Malmström, Rickard E.; Hjemdahl, Paul: Dyspnea and antiplatelet drugs: Little cause for concern with clopidogrel
519
Horowitz, John D.; Chirkov, Yuliy Y.: Identifying clopidogrel resistance during chronic therapy: The case for a biochemical approach
521
Biondi-Zoccai, Giuseppe; Lotrionte, Marzia; Sheiban, Imad: Overcoming “resistance” to aspirin and clopidogrel with tirofiban: fact or fiction?
523
Warkentin, Theodore E.: Confirmatory procedure and other maneuvers to assess pathogenicity of platelet factor 4 (PF4)-dependent antibodies – distinguishing "signal" from "noise"
525
Marco, Pascual; Lopez-Abadia, Emma; Lucas, Javier: More on thromboprophylaxis: Electronic alerts in hospitalized patients at risk of venous thromboembolism

Theme Issue Editorial

527
Benzakour, Omar: Vitamin K-dependent proteins: Functions in blood coagulation and beyond

Theme Issue Article

530
Shearer, Martin J.; Newman, Paul: Metabolism and cell biology of vitamin K
548
Vasse, Marc: Protein Z, a protein seeking a pathology
557
Hedner, Ulla: Factor VIIa and its potential therapeutic use in bleeding-associated pathologies
563
Monahan, Paul E.: Factor IX: Insights from knock-out and genetically engineered mice
576
Sokolova, Elena; Reiser, Georg: Prothrombin/thrombin and the thrombin receptors PAR-1 and PAR-4 in the brain: Localization, expression and participation in neurodegenerative diseases
582
Toltl, Lisa J.; Swystun, Laura L.; Pepler, Laura; Liaw, Patricia C.: Protective effects of activated protein C in sepsis
593
Schurgers, Leon J.; Cranenburg, Ellen C. M.; Vermeer, Cees: Matrix Gla-protein: The calcification inhibitor in need of vitamin K
604
Fernández-Fernández, Laura; Bellido-Martín, Lola; García de Frutos, Pablo: Growth arrest-specific gene 6 (GAS6)

Clinical Focus

611
Goto, Shinya: Cardiovascular risk factors in patients at high risk of atherothrombosis: What can be learned from registries?

Blood Coagulation, Fibrinolysis and Cellular Haemostasis

614
Arnold, Marie-Luise; Lichy, Christoph; Werner, Inge; Radbruch, Alexander; Wagner, Simone; Grond-Ginsbach, Caspar: Single nucleotide polymorphisms in the VKORC1 gene and the risk of stroke in the Southern German population

Platelets and Blood Cells

618
Schäfer, Andreas; Weinberger, Sarah; Flierl, Ulrike; Eigenthaler, Martin; Störk, Stefan; Walter, Ulrich; Ertl, Georg; Bauersachs, Johann: ADP-induced platelet aggregation frequently fails to detect impaired clopidogrel-responsiveness in patients with coronary artery disease compared to a P2Y12-specific assay
626
Braun, Oscar Ö.; Johnell, Matilda; arenhorst, Christoph; James, Stefan; Brandt, John T.; Jakubowski, Joseph A.; Winters, Kenneth J.; Wallentin, Lars; Erlinge, David; Siegbahn, Agneta: Greater reduction of platelet activation markers and platelet-monocyte aggregates by prasugrel compared to clopidogrel in stable coronary artery disease
634
Larson, Mark K.; Ashmore, Joseph H.; Harris, Kristina A.; Vogelaar, Jessica L.; Pottala, James V.; Sprehe, Michael; Harris, William S.: Effects of omega-3 acid ethyl esters and aspirin, alone and in combination, on platelet function in healthy subjects

Endothelium and Vascular Development

642
Strijbos, Michiel H.; Rao, Chandra; Schmitz, Paul I. M.; Kraan, Jaco; Lamers, Cor H.; Sleijfer, Stefan; Terstappen, Leon W. M. M.; Gratama, Jan W.: Correlation between circulating endothelial cell counts and plasma thrombomodulin levels as markers for endothelial damage

Cardiovascular Biology and Cell Signalling

648
Ivandic, Boris T.; Kurz, Kerstin; Keck, Frieder; Staritz, Peter; Lehrke, Stephanie; Katus, Hugo A.; Giannitsis, Evangelos: Tirofiban optimizes platelet inhibition for immediate percutaneous coronary intervention in high-risk acute coronary syndromes

Cellular Proteolysis and Oncology

655
Åberg, Mikael; Johnell, Matilda; Wickström, Malin; Widunder, Anna; Siegbahn, Agneta: Simvastatin reduces the production of prothrombotic prostasomes in human prostate cancer cells
663
Toth, Bettina; Liebhardt, Susanne; Steinig, Kerstin; Ditsch, Nina; Rank, Andreas; Bauerfeind, Ingo; Spannagl, Michael; Friese, Klaus; Reininger, Armin J.: Platelet-derived microparticles and coagulation activation in breast cancer patients

Animal Models

670
Fontayne, Alexandre; Meiring, Muriel; Lamprecht, Seb; Roodt, Jan; Demarsin, Eddy; Barbeaux, Philippe; Deckmyn, Hans: The humanized anti-glycoprotein Ib monoclonal antibody h6B4-Fab is a potent and safe antithrombotic in a high shear arterial thrombosis model in baboons

New Technologies, Diagnostic Tools and Drugs

678
Whitlatch, Nicole L.; Perry, Stephanie L.; Ortel, Thomas L.: Anti-heparin/platelet factor 4 antibody optical density values and the confirmatory procedure in the diagnosis of heparin-induced thrombocytopenia
685
Cadiou, Gwenaëlle; Varin, Rémi; Levesque, Hervé; Grassi, Vanessa; Benichou, Jacques; Tiret, Isabelle; Dieu, Bernard; Lecam-Duchez, Véronique; Borg, Jeanne-Yvonne; Muller, Jean-Michel; Benhamou, Ygal; Marie, Isabelle: Risk factors of vitamin K antagonist overcoagulation
693
Maegdefessel, Lars; Buerke, Michael; Schubert, Sebastian; Reindl, Iris; Michel, Thomas; Hauroeder, Baerbel; Carter, Justin M.; Peetz, Dirk; Werdan, Karl; Schlitt, Axel: Comparison of bivalirudin, enoxaparin, and unfractionated heparin in preventing cardiac catheter thrombosis
699
Lecumberri, Ramón; Marqués, Margarita; Díaz-Navarlaz, María Teresa; Panizo, Elena; Toledo, Jon; García-Mouriz, Alberto; Páramo, José A.: Maintained effectiveness of an electronic alert system to prevent venous thromboembolism among hospitalized patients

Case Report

705
Weigert, Oliver; Wittmann, Georg; Gruetzner, Stefanie; Cnossen, Jitske; Becker, Marie-Christine; Dreyling, Martin; Ostermann, Helmut: Successful salvage treatment of chronic refractory immune thrombocytopenia using a simplified method to generate vincristine-loaded platelets
708
Davis, Ryan L.; Baker, Bartrum; Brennan, Stephen O.: Fibrinogen Foxton: A novel BβA277V mutation causing low normal plasma fibrinogen concentration
711
Marschang, Peter; Niederwanger, Andreas; Gasser, Rudolf W.; Daniaux, Martin; Sturm, Wolfgang: Symptomatic upper extremity deep vein thrombosis as a complication of ambulatory blood pressure monitoring

Letters to the Editor

713
Aleil, Boris; Kessler, Laurence; Meyer, Nicolas; Wiesel, Marie-Louise; Simeoni, Julia; Cazenave, Jean-Pierre; Pinget, Michel; Gachet, Christian; Lanza, François: Plasma levels of soluble platelet glycoprotein V are linked to fasting blood glucose in patients with type 2 diabetes
716
Lester, William; Guilliatt, Andrea; Grundy, Pamela; Enayat, Said; Millar, Carolyn; Hill, Frank; Cumming, Tony; Collins, Peter: Is VWF R924Q a benign polymorphism, a marker of a null allele or a factor VIII-binding defect? The debate continues with results from the UKHCDO VWD study
718
Pengo, Vittorio; Palareti, Gualtiero; Cosmi, Benilde; Legnani, Cristina; Tosetto, Alberto; Alatri, Adriano; Marzot, Filippo; Pegoraro, Cinzia; Cucchini, Umberto; Iliceto, Sabino; for the PROLONG Investigators (on behalf of FCSA, Italian Federation of Anticoagulation Clinics): D-dimer testing and recurrent venous thromboembolism after unprovoked pulmonary embolism: A post-hoc analysis of the prolong extension study
721
Hurtado, Begoña; Abasolo, Nerea; Domènech-Santasusana, Pere; Fuentes-Prior, Pablo; de Frutos, Pablo García; Sala, Núria: Confirmation of inherited protein S deficiency by PROS1 mutational screening: Identification of three novel PROS1 mutations and haplotype analysis of p.Q279X recurrence
725
Breugelmans, Jaimie; Vertessen, Francine; Mertens, Gerhard; Gadisseur, Alain; Van der Planken, Marc: Multiplate whole blood impedance aggregometry: A recent experience