Klinische Pädiatrie

Issue 03 · May 2019

eFirst
Issue
Kind-Philipp-Stiftung für pädiatrisch-onkologische Forschung
32. Jahrestagung der Kind-Philipp-Stiftung für pädiatrisch onkologische Forschung
Wilsede, 05.–07.06.2019

Wissenschaftliche Leitung: Prof. Dr. Jan-Henning Klusmann, Martin-Luther-Univsersität Halle-Wittenberg Prof. Dr. Martin Stanulla, Medizinische Hochschule Hannover Prof. Dr. Rolf Marschalek, Goethe-Universität, Frankfurt (Main) Prof. Dr. Olaf Heidenreich, Prinses Máxima Centrum voor Kinderoncologie, Utrecht, Niederlande

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- Abstracts
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Zanetti, SR; Velazco-Hernandez, T; Gutierrez-Agüera, F; Roca-Ho, H; Sánchez-Martínez, D; Petazzi, P; Torres, R; Molina, O; Torrebadell-Burriel, M; Vidriales-Vicente, MB; Hrusak, O; Fuster, JL; Juan, M; Bueno, C; Menéndez, P: CD19 and CD22-directed biespecific CAR for B-cell Acute Lymphoblastic Leukemia FREE ACCESS
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2
Molina, O; Bueno, C; Bosch, A; Granada, I; Roca-Ho, H; Gutierrez-Agüera, F; Tirados, S; Pal, D; Ballerini, P; deBoer, M; Plensa, I; Calasanz, MJ; Rodríguez, R; Camos, M; Calvo, M; Menendez, P: Chromosome structure and mitotic defects are major pathogenic mechanisms in hyperdiploid childhood B-ALL FREE ACCESS
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3
Torres-Ruiz, R; Bueno, C; Velasco-Hernandez, T; Roca-Ho, H; Gutierrez-Aguera, F; Quintana, O; Segovia, JC; Roy, A; Rodriguez-Perales, S; Menendez, P: CRISPR-mediated genome editing of t(4;11) in human prenatal and perinatal hematopoietic stem/progenitor cells FREE ACCESS
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4
Bueno, C; Tejedor, JR; Bashford-Rogers, R; Gonzalez Silva, L; Valdés-Mas, R; Fraga, MF; Fernandez, A; Ballerini, P; Varela, I; Menendez, P: Evolutionary trajectories and cell-of-origin of TCF3-ZNF384&PTPN11 mutations in monozygotic twins with concordant B-ALL FREE ACCESS
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5
Tauchmann, S; Almosailleakh, M; Leonards, K; Otzen Bagger, F; Juge, S; Thirant, C; Méreau, H; Peters, AHFM; Mercher, T; Schwaller, J: Inactivation of Nsd1 impairs terminal erythroid maturation and induces erythroleukemia FREE ACCESS
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6
Goschzik, T; Dörner, E; zur Mühlen, A; Pietsch, T: WNT Medulloblastoma: More than just β-Catenin Mutations – Rare Genetic Features in the Focus FREE ACCESS
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7
Wiedey, A; Doerner, E; zur Mühlen, A; Kramm, C; Waha, A; Pietsch, T: Giant cell glioblastoma does not represent a distinct entity but stratifies into different genetically defined entities FREE ACCESS
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8
Zierk, J; Rauh, M; Frömmel, C; Nöllke, P; Niemeyer, CM; Metzler, M: Machine learning algorithms for the automated classification of pediatric anemia FREE ACCESS
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9
Krumbholz, M; Goerlitz, K; Albert, C; Lawlor, J; Volz, C; Suttorp, M; Metzler, M: Large amplicon droplet digital PCR for DNA-based monitoring of pediatric chronic myeloid leukemia (CML) FREE ACCESS
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10
Eiblwieser, J; Krumbholz, M; Semper, S; Zierk, J; Metzler, M: Multiplex Droplet Digital PCR-based Targeted Enrichment NGS for identification of tumor markers in Ewing Sarcoma (EwS) FREE ACCESS
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11
Metzler, M; Diets, IJ; Hoyer, J; Wegert, J; Graf, N; Vokuhl, C; Gessler, M; Kuiper, RP; Jongmans, MCJ: TRIM28 haploinsufficiency predisposes to Wilms tumor FREE ACCESS
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12
Luciano, V; Heering, J; Proschak, E; Marschalek, R: Screening assay to identify potential Taspase1 inhibitors FREE ACCESS
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13
Wilhelm, A; Marschalek, R: Investigating HDACi and dnTaspase1 for the treatment of t(4;11) leukemic cells FREE ACCESS
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14
Mittapalli, VR; Andrieux, G; Hochrein, J; Vukicevic, V; Kratz, CP; Niemeyer, CM; Börries, M; Erlacher, M: Mutational and transcriptomic landscapes in hematopoietic cells of Fanconi anemia patients FREE ACCESS
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15
Koleci, N; Wu, Y; Mittapalli, VR; Bohler, S; Molnar, C; Weiss, JM; Erlacher, M: Analyzing the effects of oncogenic SHP2 on apoptosis signaling during malignant transformation FREE ACCESS
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16
Wu, Y; Koleci, N; Gallego-Villar, L; Mittapalli, VR; Bohler, S; Erlacher, M: Analyzing the therapeutic efficacy of navitoclax and MCL-1 inhibitors in juvenile myelomonyctic leukemia FREE ACCESS
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17
Weiss, JM; Mittapalli, VM; Molnar, C; Schmitt, I; Andrieux, G; Gonzalez, I; Börries, M; Quintanilla-Martinez, L; Niemeyer, CM; Erlacher, M: Too little is too much: Leukemogenesis in the Gata2 syndrome FREE ACCESS
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18
Troschke-Meurer, S; Siebert, N; Marx, M; Zumpe, M; Ehlert, K; Loibner, H; Ladenstein, R: Low regulatory T-cells are associated with improved survival of neuroblastoma patients treated with anti-GD2 antibodies FREE ACCESS
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19
Marx, M; Troschke-Meurer, S; Zumpe, M; Lode, H; Siebert, N: Blockade of suppressive myeloid cells is effective against neuroblastoma FREE ACCESS
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20
Lein, P; Volkmer, I; Alejo-Valle, O; Klusmann, JH; Staege, MS: Identification of a new splice variant of the human transcription factor ONECUT2 FREE ACCESS
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21
Bräuer-Hartmann, D; Gialesaki, S; Labuhn, M; Heckl, D; Klusmann, JH: Identification of GATA1 s interaction partners in Down syndrome-associated myeloid leukemia FREE ACCESS
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22
Samulowski, D; Bhayadia, R; Heckl, D; Klusmann, JH: Establishment of new therapeutic options for the treatment of Myeloid Leukemia in Down syndrome (ML-DS) FREE ACCESS
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23
Verboon, LJ; Schneider, D; Xu, J; Heckl, D; Klusmann, JH: Deciphering the interactive network of the DLK1-DIO3 locus in hematopoiesis and pediatric acute megakaryoblastic leukemia FREE ACCESS
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24
Issa, H; Bhayadia, R; Klusmann, JH: Therapeutic application of the tumour suppressive miR-193b in Acute Myeloid Leukaemia FREE ACCESS
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25
Alejo-Valle, O; Labuhn, M; Emmrich, E; Ng, M; Heckl, D; Klusmann, JH: Cooperativity between miR-125b and Gata1 s in the pathogenesis of Down syndrome-associated myeloid leukemia FREE ACCESS
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26
Ng, M; Bhayadia, R; Schwarzer, A; Heckl, D; Klusmann, JH: CRISPRi screen to identify functional long noncoding RNAs in pediatric acute myeloid leukemia FREE ACCESS
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27
Bhayadia, R; Ng, M; Dirk, H; Klusmann, JH: Deciphering the role of lncRNAs in pediatric AML FREE ACCESS
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28
Cui, W; Guan, Y; Xydous, M; Schlüter, H; Sternsdorf, T: Using Acute Promyelocytic Leukemia to study the H3.3 Histone chaperone system and its role in pediatric malignancies FREE ACCESS
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29
Vu-Han, TL; Lam, FC; van de Kooij, B; Bandopadhayay, P; Beroukhim, R; Sarkaria, J; Horstmann, M; Yaffe, MB: Interrogating the Role of Chromatin Regulator BRD4 in the DNA Damage Response in Medulloblastoma FREE ACCESS
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30
Hinze, L; Pfirrmann, M; Karim, S; Degar, J; Bauer, DE; Gregory, RI; Stanulla, M; Wagner, F; Stegmaier, K; Gutierrez, A: Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias FREE ACCESS
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31
Decker, M; Schlegelberger, B; Illig, T; Ripperger, T: Functional characterization of RUNX1 variants in the context of FPDMM FREE ACCESS
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32
Vollmer, J; Ecker, J; Hielscher, T; Oehme, I; Oppermann, S; Peterziel, H; Witt, O; Milde, T: Functional analysis of class I HDAC inhibition in group 3 medulloblastoma to identify synergistic drug combinations FREE ACCESS
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33
Buellesbach, A; Johann, PD; Lappalainen, K; Okonechnikov, K; Jones, DTW; Pfister, SM; Hasselblatt, M; Kool, M: Mapping the single cell transcriptome reveals the cellular composition of ATRT subgroups FREE ACCESS
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34
Müller, J; Fedders, B; Cario, G; Schrappe, M; Schewe, D; Möricke, A; Lilljebjörn, H; Fioretos, T; Zimmermann, M; Stanulla, M: Stratification and prognosis of IGH-DUX4 positive acute lymphoblastic leukemia in children FREE ACCESS
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35
Spory, L; Lenk, L; Winterberg, D; Alsadeq, A; Carlet, M; Jeremias, I; Cario, G; Schrappe, M; Vossen-Gajcy, M; Schewe, DM: FOS and FOSB are linked with CNS-infiltration and inferior prognosis in childhood T-cell acute lymphoblastic leukemia FREE ACCESS
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36
Heymann, J; Vogiatzi, F; Rösner, T; Lenk, L; Cario, G; Schrappe, M; Valerius, T; Peipp, M; Kellner, C; Schewe, DM: Venetoclax enhances the efficacy of therapeutic antibodies in B-cell malignancies FREE ACCESS
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37
Alameri, M; Bartram, J; Williams, O; de Boer, J: Epigenetics profiling for minimal residual disease in paediatric acute myeloid leukaemia FREE ACCESS
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38
Clesham, KJ; Gasparoli, L; Virely, C; Cantilena, S; De Boer, J; Williams, O: Targeting c-MYB in Acute Leukaemia through Drug Repositioning FREE ACCESS
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39
Looi-Somoye, R; Cantilena, S; Williams, O; de Boer, J: Drug Repositioning in Infant Leukaemia FREE ACCESS
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40
Jiang, T; Vokuhl, C; Schweinitz, D von; Kappler, R: Tripartite motif-containing 71 (TRIM71) is a major factor of oncogenic activity in human hepatoblastoma FREE ACCESS
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41
Bentrop, M; Vokuhl, C; Schweinitz, D von; Kappler, R: Inhibition of the polycomb repressive complex 1 (PRC1) as a therapeutic option in childhood liver tumors FREE ACCESS
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42
Bartholomé, R; Arner, A; Becker, M; Jeremias, I; Binder, V: Isolation and characterization of tumor-derived exosomes from a patient-derived xenograft mouse model of acute leukemia FREE ACCESS
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43
Moorthy, S; Bomken, S; Ponthan, F; Pal, D; Elder, A; Nakjang, S; Grinev, V; Vormoor, J: Splicing factors of the SF3b complex PHF5A and SF3B1 regulate the DNA damage response in ALL FREE ACCESS
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44
Shi, Y; Beckett, M; Blair, H; Tirtakusuma, R; Nakjang, S; Enshaei, A; Heidenreich, O; Krippner-Heidenreich, A; Van Delft, F: Dasatinib and Dexamethasone offer a novel therapeutic strategy for T-cell Acute Lymphoblastic Leukaemia FREE ACCESS
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45
Szoltysek, K; Dormon, K; Blair, H; Tirtakusuma, R; Dodd, C; Law, E; Nakjang, S; Pal, D; Vormoor, J; Heidenreich, O: Genome-wide CRISPR screen in patient derived cells reveals the mechanism of ALL chemoresistance FREE ACCESS
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46
Tirtakusuma, R; Milne, P; Ptasinska, A; Williamson, D; Blair, H; Meyer, C; Marschalek, R; Bonifer, C; Bomken, S; Heidenreich, O: Genomic characterisation of lineage switched MLL-rearranged leukemias FREE ACCESS
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47
Ritter, MU; Klimenkova, O; Klimiankou, M; Schmidt, A; Stocking, C; Kanz, L; Zeidler, C; Link, DC; Welte, K; Skokowa, J: Downstream effect of CSF3R and RUNX1 mutations that underlie leukemic transformations in congenital neutropenia (CN) FREE ACCESS
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48
Nasri, M; Dannenmann, B; Ritter, M; Mir, P; Xu, Y; Klimiankou, M; Zeidler, C; Kanz, L; Welte, K; Skokowa, J: CRISPR/Cas9 Gene-modification Platform of ELANE Mutations in iPSCs and HSPCs of Severe Congenital Neutropenia Patients FREE ACCESS
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49
Dannenmann, B; Klimiankou, M; Mardan, J; Oswald, B; Solovyeva, A; Ritter, M; Kanz, L; Zeidler, C; Welte, K; Skokowa, J: iPSC Model of Stepwise Leukemia Development in Congenital Neutropenia Reveals BAALC as a Key Mediator of Leukemogenesis FREE ACCESS
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50
Mir, P; Klimiankou, M; Nasri, M; Dannenmann, B; Findik, B; Rieger, M; Kanz, L; Zeidler, C; Welte, K; Skokowa, J: GADD45b plays an essential role in the G-CSF triggered granulocytic differentiation of human hematopoietic cells FREE ACCESS
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51
Morishima, T; Krahl, AC; Xu, Y; Aghaallaei, N; Nasri, M; Findik, B; Bajoghli, B; Müller, P; Welte, K; Skokowa, J: NAMPT-mediated LMO2 deacetylation is indispensable for hematopoiesis and T-ALL leukemogenesis FREE ACCESS
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52
Bell, H; Lalnunhlimi, S; Green, M; Van Delft, F; Krippner-Heidenreich, A: Tumour Necrosis Factor receptor (TNFR)-signalling dependent killing in T-cell acute lymphoblastic leukaemia (T-ALL) FREE ACCESS
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53
Gerber, T; Taschner-Mandl, S; Buder, A; Saloberger, L; Berneder, M; Brunner-Herglotz, B; Ziegler, A; Ladenstein, R; Ambros, IM; Ambros, PF: Liquid biopsy in neuroblastoma: cfDNA analysis for sensitive follow-up monitoring and early relapse detection FREE ACCESS
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