DOI:
        10.1055/s-00000077
      
      
        Seminars in Thrombosis and Hemostasis
       
      
        
          
            Issue 03 · 
           Volume 51 · 
           April 2025
            
           
           DOI: 10.1055/s-015-61300  
          
            
          
          Guest Editor: Sam Schulman, MD 
          
        
        
  
  
    
      Accepted Manuscripts
     
  
  
  
    
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                            Preface 
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                            
                          
                          
                          
                          
  
  
    
      
        253
      
    
   
  
  
 
                      
                          
                          
                            Review Article 
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                            
                          
                          
                          
                          
  
  
    
      
        256
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Kruger, Arneaux; 
              
            
          
            
              
              Joffe, David; 
              
            
          
            
              
              Lloyd-Jones, Graham; 
              
            
          
            
              
              Khan, Muhammed Asad; 
              
            
          
            
              
              Šalamon, Špela; 
              
            
          
            
              
              Laubscher, Gert J.; 
              
            
          
            
              
              Putrino, David; 
              
            
          
            
              
              Kell, Douglas B.; 
              
            
          
            
              
              Pretorius, Etheresia: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
        
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
        272
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Zhang, Bihui; 
              
            
          
            
              
              Yao, Ziping; 
              
            
          
            
              
              Li, Pengyu; 
              
            
          
            
              
              Niu, Guochen; 
              
            
          
            
              
              Yan, Ziguang; 
              
            
          
            
              
              She, Kang; 
              
            
          
            
              
              Cheng, Gong; 
              
            
          
            
              
              Yang, Min: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
        
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
        279
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Li, Yuhong; 
              
            
          
            
              
              Tong, Ling; 
              
            
          
            
              
              Zhang, Youqian; 
              
            
          
            
              
              Huang, Birun; 
              
            
          
            
              
              Zhu, Liping: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
        
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
        290
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Yong, Bryan Song Jun; 
              
            
          
            
              
              Ling, Ryan Ruiyang; 
              
            
          
            
              
              Li, Ruiqi; 
              
            
          
            
              
              Poh, Jane Wenjin; 
              
            
          
            
              
              Tan, Chuen Seng; 
              
            
          
            
              
              Ho, Sean Wei Loong; 
              
            
          
            
              
              Rochwerg, Bram; 
              
            
          
            
              
              Arya, Roopen; 
              
            
          
            
              
              Ramanathan, Kollengode; 
              
            
          
            
              
              Fan, Bingwen Eugene: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
        
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
        301
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Brenner, Benjamin; 
              
            
          
            
              
              Tzoran, Inna; 
              
            
          
            
              
              Bikdeli, Behnood; 
              
            
          
            
              
              Valle, Reina; 
              
            
          
            
              
              Poenou, Géraldine; 
              
            
          
            
              
              Tirado-Miranda, Raimundo; 
              
            
          
            
              
              Pesce, María L.; 
              
            
          
            
              
              Pagán-Escribano, Javier; 
              
            
          
            
              
              Giorgi-Pierfranceschi, Matteo; 
              
            
          
            
              
              Monreal, Manuel; 
              
            
          
            
              
              
                
                
                  
                
                  
                
                  
                
                  
                
                  
                
                  
                
                  
                
                  
                
                  
                
                  
                
                  
                
                
                
                
                  
                
                  
                
                  
                
                  
                
                  
                
                  
                
                  
                
                  
                
                  
                
                  
                
                  
                
                
                  the RIETE Investigators: 
                
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
        
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
        312
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Franchini, Massimo; 
              
            
          
            
              
              Focosi, Daniele; 
              
            
          
            
              
              Pezzo, Mario Piergiulio; 
              
            
          
            
              
              Mannucci, Pier Mannuccio: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
        322
      
    
   
  
  
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
        329
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Kiskaddon, Amy L.; 
              
            
          
            
              
              Branstetter, Josh; 
              
            
          
            
              
              Williams, Pam; 
              
            
          
            
              
              Ignjatovic, Vera; 
              
            
          
            
              
              Memken, Amanda; 
              
            
          
            
              
              Wilhoit, Kristopher; 
              
            
          
            
              
              Goldenberg, Neil A.: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
        
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
        335
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Kiskaddon, Amy L.; 
              
            
          
            
              
              Giglia, Therese M.; 
              
            
          
            
              
              Betensky, Marisol; 
              
            
          
            
              
              Do, Nhue L.; 
              
            
          
            
              
              Witt, Daniel M.; 
              
            
          
            
              
              Stock, Arabela C.; 
              
            
          
            
              
              Amankwah, Ernest K.; 
              
            
          
            
              
              Fierstein, Jamie L.; 
              
            
          
            
              
              Ashour, Dina; 
              
            
          
            
              
              Ignjatovic, Vera; 
              
            
          
            
              
              Quintessenza, James A.; 
              
            
          
            
              
              Goldenberg, Neil A.: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
        
      
    
   
 
                      
                          
                          
                            Letter to the Editor 
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                            
                          
                          
                          
                          
  
  
    
      
        343
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Wilson, Hope P.; 
              
            
          
            
              
              Mosha, Maua; 
              
            
          
            
              
              Miller, Alexandra; 
              
            
          
            
              
              Betensky, Marisol; 
              
            
          
            
              
              Amankwah, Ernest; 
              
            
          
            
              
              Fargo, John; 
              
            
          
            
              
              Thornburg, Courtney D.; 
              
            
          
            
              
              Tarango, Cristina; 
              
            
          
            
              
              Acharya, Suchitra; 
              
            
          
            
              
              Male, Christoph; 
              
            
          
            
              
              Narang, Shalu; 
              
            
          
            
              
              Schulman, Sam; 
              
            
          
            
              
              Goldenberg, Neil A.: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
        348
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
          
          
            
              
              Lu, Jiawen; 
              
            
          
            
              
              Wang, Zhenqian: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
        351
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Chen, Ziyang; 
              
            
          
            
              
              Wu, Hualan; 
              
            
          
            
              
              Xu, Yuan; 
              
            
          
            
              
              Gu, Tao; 
              
            
          
            
              
              Liu, Deping; 
              
            
          
            
              
              Lan, Ming: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                            
                            Commentary 
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                            
                          
                          
                          
                          
  
  
    
      
        355
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Hirsh, Jack; 
              
            
          
            
              
              Godoy, Alejandro; 
              
            
          
            
              
              Chan, Noel C.: 
              
            
          
       
    
    
    
    
      
      
        
      
      
        
        
        
      
    
    
      
    
    
    
    
    
    
    
      
    
   
 
                      
                          
                          
                          
                          
                          
                            
                          
                          
                            
                          
                          
                          
                          
                          
                          
  
  
    
      
        358
      
    
   
  
  
    
    
    
      
    
    
      
        
          
            
              
            
          
            
              
            
          
            
              
            
          
            
              
            
          
          
          
            
              
              Favaloro, Emmanuel J.; 
              
            
          
            
              
              Pasalic, Leonardo; 
              
            
          
            
              
              Fan, Bingwen Eugene; 
              
            
          
            
              
              Lippi, Giuseppe: