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Int J Angiol 1995; 4(1): 8-11
DOI: 10.1007/BF02043498
Original Articles

© Georg Thieme Verlag KG Stuttgart · New York

High energy phosphates in postischemic myocardium with reduced or normalized function

Hans Martin Hoffmeister1 , Martin E. Beyer1 , Günther Fenchel2 , Ludger Seipel1
  • 1Medizinische Universitätsklinik, Abt. III, Eberhard-Karls-Universität Tübingen, Tübingen, Germany
  • 2Abt. für Thorax-, Herz- und Gefäßchirugie, Eberhard-Karls-Universität Tübingen, Tübingen, Germany
Presented at The 35th Annual Congress, International College of Angiology, Copenhagen, Denmark, July 1993
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Publication History

Publication Date:
22 April 2011 (online)

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Abstract

Mitochondrial damage and decreased levels of high energy phosphates are well-known findings in reversibly injured postischemic myocardium (=stunning). Using an isovolumetrically beating isolated rat heart preparation (Langendorff perfusion apparatus) we investigated the effect of postischemic positive inotropic stimulation on the myocardial high energy phosphate content. During postischemic functional steady state with moderately reduced left ventricular developed pressure (118.7 mmHg after 30 minutes of ischemia vs 136.1 mmHg preischemic), dopamine in a dose to reestablish preischemic function was administered for a 20-minute period. Data were compared with postischemic hearts without positive inotropic stimulation: ATP was 2.5 vs 2.5 (μmol/g ww; phosphocreatine was 5.5 vs 6.7 μmol/g ww. These findings indicate that reversibly injured postischemic myocardium can be stimulated for a prolonged period without loss of high-energy phosphates. Therefore, a failure of the energy-generating apparatus is not the reason for the reversible postischemic dysfunction.