Enantioselective C–H Alkylation of N-Arylbenzamides with Vinyl Ethers Catalyzed by an Iridium/Chiral Phosphoramidite–Olefin Complex

Abstract

Chiral phosphoramidite–olefin hybrid ligands were found to be effective in the iridium-catalyzed asymmetric alkylation of N-arylbenzamides with vinyl ethers. The reaction is catalyzed by a hydroxo­iridium catalyst coordinated with the hybrid ligand to give the corresponding products in high yields with high branch selectivity and enantioselectivity.

Key words

enantioselectivity - iridium - benzamides - catalysis - C–H activation­

Publication History

Received: 27 September 2021

Accepted after revision: 19 October 2021

Accepted Manuscript online:
19 October 2021

Article published online:
01 December 2021

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