Enantioselective C–H Alkylation of N-Arylbenzamides with Vinyl Ethers Catalyzed by an Iridium/Chiral Phosphoramidite–Olefin Complex

Kotone Murakami; Kana Sakamoto; Takahiro Nishimura

doi:10.1055/a-1672-6284

Synthesis, Table of Contents

Synthesis 2022; 54(21): 4753-4763
DOI: 10.1055/a-1672-6284

special topic

Asymmetric C–H Functionalization

Enantioselective C–H Alkylation of N-Arylbenzamides with Vinyl Ethers Catalyzed by an Iridium/Chiral Phosphoramidite–Olefin Complex

Kotone Murakami

,

Kana Sakamoto

,

Takahiro Nishimura ∗

Abstract

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Abstract

Chiral phosphoramidite–olefin hybrid ligands were found to be effective in the iridium-catalyzed asymmetric alkylation of N-arylbenzamides with vinyl ethers. The reaction is catalyzed by a hydroxoiridium catalyst coordinated with the hybrid ligand to give the corresponding products in high yields with high branch selectivity and enantioselectivity.

Key words

enantioselectivity - iridium - benzamides - catalysis - C–H activation

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References

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