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Facial Plast Surg 2023; 39(03): 220-229
DOI: 10.1055/a-2008-2798
Original Article

State of the Evidence for Facial Skin Cancer Reconstruction

Nicole G. Desisto
1   Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, Tennessee
,
Alexandra S. Ortiz
1   Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, Tennessee
,
Shiayin F. Yang
1   Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, Tennessee
,
Scott J. Stephan
1   Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, Tennessee
,
Priyesh N. Patel
1   Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, Tennessee
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Abstract

This review provides a comprehensive presentation of the evidence available in facial reconstruction post-Mohs micrographic surgery. Given the large diversity in post-Mohs reconstruction, there are limited guidelines in the management of defects. The aim of the present work is to provide a review of the best evidence as it pertains to several considerations in facial reconstruction. Data suggests that Mohs micrographic surgery and many reconstructive procedures can be performed as outpatient procedures under local anesthesia, with narcotic pain medication only given in certain patient populations following a minority of reconstructive procedures. Perioperative and topical antibiotics are generally not indicated. Aspirin and warfarin can generally be continued for most reconstructive procedures, but clopidogrel and novel anticoagulants may predispose to increased bleeding complications. Delayed reconstruction appears to be safe, although data are discordant on this topic. No specific wound closure technique or suture choice appears to be consistently superior. Given the lack of robust comparative studies, consistent methodology, and variable defect sizes/locations, no robust evidence-based guidelines can be generated for reconstruction techniques of facial subsites.

Keywords

skin cancer - Mohs reconstruction - facial reconstruction - evidence-based medicine


Publikationsverlauf

Accepted Manuscript online:
05. Januar 2023

Artikel online veröffentlicht:
22. Februar 2023

© 2023. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

  • References

  • 1 Lim HW, Collins SAB, Resneck Jr JS. et al. The burden of skin disease in the United States. J Am Acad Dermatol 2017; 76 (05) 958-972
    CrossrefPubMedGoogle Scholar
  • 2 Kim JYS, Kozlow JH, Mittal B, Moyer J, Olencki T, Rodgers P. Work Group, Invited Reviewers. Guidelines of care for the management of basal cell carcinoma. J Am Acad Dermatol 2018; 78 (03) 540-559
    CrossrefPubMedGoogle Scholar
  • 3 Kim JYS, Kozlow JH, Mittal B, Moyer J, Olenecki T, Rodgers P. Work Group, Invited Reviewers. Guidelines of care for the management of cutaneous squamous cell carcinoma. J Am Acad Dermatol 2018; 78 (03) 560-578
    CrossrefPubMedGoogle Scholar
  • 4 Kouba DJ, LoPiccolo MC, Alam M. et al. Guidelines for the use of local anesthesia in office-based dermatologic surgery. J Am Acad Dermatol 2016; 74 (06) 1201-1219
    CrossrefPubMedGoogle Scholar
  • 5 Häfner HM, Röcken M, Breuninger H. Epinephrine-supplemented local anesthetics for ear and nose surgery: clinical use without complications in more than 10,000 surgical procedures. J Dtsch Dermatol Ges 2005; 3 (03) 195-199
    CrossrefPubMedGoogle Scholar
  • 6 McLawhorn JM, Clark S, Lander S. et al. Incidence of epinephrine reactions with local anesthesia in Mohs micrographic surgery. Dermatol Surg 2020; 46 (05) 581-585
    CrossrefPubMedGoogle Scholar
  • 7 Welch MN, Czyz CN, Kalwerisky K, Holck DEE, Mihora LD. Double-blind, bilateral pain comparison with simultaneous injection of 2% lidocaine versus buffered 2% lidocaine for periocular anesthesia. Ophthalmology 2012; 119 (10) 2048-2052
    CrossrefPubMedGoogle Scholar
  • 8 Masters JE. Randomised control trial of pH buffered lignocaine with adrenaline in outpatient operations. Br J Plast Surg 1998; 51 (05) 385-387
    CrossrefPubMedGoogle Scholar
  • 9 Burns CA, Ferris G, Feng C, Cooper JZ, Brown MD. Decreasing the pain of local anesthesia: a prospective, double-blind comparison of buffered, premixed 1% lidocaine with epinephrine versus 1% lidocaine freshly mixed with epinephrine. J Am Acad Dermatol 2006; 54 (01) 128-131
    CrossrefPubMedGoogle Scholar
  • 10 Chen P, Smith H, Vinciullo C. Bupivacaine as an adjunct to lidocaine in Mohs micrographic surgery: a prospective randomized controlled trial. Dermatol Surg 2018; 44 (05) 607-610
    CrossrefPubMedGoogle Scholar
  • 11 Morganroth PA, Gelfand JM, Jambusaria A, Margolis DJ, Miller CJ. A randomized, double-blind comparison of the total dose of 1.0% lidocaine with 1:100,000 epinephrine versus 0.5% lidocaine with 1:200,000 epinephrine required for effective local anesthesia during Mohs micrographic surgery for skin cancers. J Am Acad Dermatol 2009; 60 (03) 444-452
    CrossrefPubMedGoogle Scholar
  • 12 Kimyai-Asadi A, Goldberg LH, Peterson SR, Silapint S, Jih MH. The incidence of major complications from Mohs micrographic surgery performed in office-based and hospital-based settings. J Am Acad Dermatol 2005; 53 (04) 628-634
    CrossrefPubMedGoogle Scholar
  • 13 Alam M, Ibrahim O, Nodzenski M. et al. Adverse events associated with Mohs micrographic surgery: multicenter prospective cohort study of 20,821 cases at 23 centers. JAMA Dermatol 2013; 149 (12) 1378-1385
    CrossrefPubMedGoogle Scholar
  • 14 Gourishetti SC, Chen JH, Isaiah A, Vakharia K. Predictors of postoperative complications after paramedian forehead flaps. Facial Plast Surg Aesthet Med 2021; 23 (06) 469-475
    CrossrefPubMedGoogle Scholar
  • 15 Newlove T, Cook J. Safety of staged interpolation flaps after Mohs micrographic surgery in an outpatient setting: a single-center experience. Dermatol Surg 2013; 39 (11) 1671-1682
    CrossrefPubMedGoogle Scholar
  • 16 Wong N, Godinez-Puig V, Makdisi J, Zloty D, Kossintseva I. Interpolation flaps in the outpatient Mohs surgery setting: a prospective cohort study of patient pain, anxiety, and satisfaction. Dermatol Surg 2021; 47 (01) 24-29
    CrossrefPubMedGoogle Scholar
  • 17 Patrinely Jr JR, Darragh C, Frank N, Danford BC, Wheless L, Clayton A. Risk of adverse events due to high volumes of local anesthesia during Mohs micrographic surgery. Arch Dermatol Res 2021; 313 (08) 679-684
    CrossrefPubMedGoogle Scholar
  • 18 Wan AY, Biro M, Scott JF. Pharmacologic and nonpharmacologic interventions for perioperative anxiety in patients undergoing Mohs micrographic surgery: a systematic review. Dermatol Surg 2020; 46 (03) 299-304
    CrossrefPubMedGoogle Scholar
  • 19 Rogers HD, Desciak EB, Marcus RP, Wang S, MacKay-Wiggan J, Eliezri YD. Prospective study of wound infections in Mohs micrographic surgery using clean surgical technique in the absence of prophylactic antibiotics. J Am Acad Dermatol 2010; 63 (05) 842-851
    CrossrefPubMedGoogle Scholar
  • 20 Rosengren H, Heal CF, Buttner PG. Effect of a single prophylactic preoperative oral antibiotic dose on surgical site infection following complex dermatological procedures on the nose and ear: a prospective, randomised, controlled, double-blinded trial. BMJ Open 2018; 8 (04) e020213
    CrossrefPubMedGoogle Scholar
  • 21 Chen A, Albertini JG, Bordeaux JS. et al. Evidence-based clinical practice guideline: reconstruction after skin cancer resection. J Am Acad Dermatol 2021; 85 (02) 423-441
    CrossrefPubMedGoogle Scholar
  • 22 Zhang Y, Dong J, Qiao Y, He J, Wang T, Ma S. Efficacy and safety profile of antibiotic prophylaxis usage in clean and clean-contaminated plastic and reconstructive surgery: a meta-analysis of randomized controlled trials. Ann Plast Surg 2014; 72 (01) 121-130
    CrossrefPubMedGoogle Scholar
  • 23 Maragh SLH, Brown MD. Prospective evaluation of surgical site infection rate among patients with Mohs micrographic surgery without the use of prophylactic antibiotics. J Am Acad Dermatol 2008; 59 (02) 275-278
    CrossrefPubMedGoogle Scholar
  • 24 Maragh SL, Otley CC, Roenigk RK, Phillips PK. Division of Dermatologic Surgery, Mayo Clinic, Rochester, MN. Antibiotic prophylaxis in dermatologic surgery: updated guidelines. Dermatol Surg 2005; 31 (01) 83-91
    CrossrefPubMedGoogle Scholar
  • 25 Patel PN, Jayawardena ADL, Walden RL, Penn EB, Francis DO. Evidence-based use of perioperative antibiotics in otolaryngology. Otolaryngol Head Neck Surg 2018; 158 (05) 783-800
    CrossrefPubMedGoogle Scholar
  • 26 Taylor O, Li JN, Carr C. et al. The effect of antibiotic prophylaxis on infection rates in Mohs micrographic surgery: a single-institution retrospective study. Arch Dermatol Res 2021; 313 (08) 663-667
    CrossrefPubMedGoogle Scholar
  • 27 Mailler-Savage EA, Neal Jr KW, Godsey T, Adams BB, Gloster Jr HM. Is levofloxacin necessary to prevent postoperative infections of auricular second-intention wounds?. Dermatol Surg 2008; 34 (01) 26-30 , discussion 30–31
    CrossrefPubMedGoogle Scholar
  • 28 Xia Y, Cho S, Greenway HT, Zelac DE, Kelley B. Infection rates of wound repairs during Mohs micrographic surgery using sterile versus nonsterile gloves: a prospective randomized pilot study. Dermatol Surg 2011; 37 (05) 651-656
    CrossrefPubMedGoogle Scholar
  • 29 Rhinehart MBM, Murphy MME, Farley MF, Albertini JG. Sterile versus nonsterile gloves during Mohs micrographic surgery: infection rate is not affected. Dermatol Surg 2006; 32 (02) 170-176
    PubMedGoogle Scholar
  • 30 Mehta D, Chambers N, Adams B, Gloster H. Comparison of the prevalence of surgical site infection with use of sterile versus nonsterile gloves for resection and reconstruction during Mohs surgery. Dermatol Surg 2014; 40 (03) 234-239
    CrossrefPubMedGoogle Scholar
  • 31 Dixon AJ, Dixon MP, Dixon JB. Randomized clinical trial of the effect of applying ointment to surgical wounds before occlusive dressing. Br J Surg 2006; 93 (08) 937-943
    CrossrefPubMedGoogle Scholar
  • 32 Campbell RM, Perlis CS, Fisher E, Gloster Jr HM. Gentamicin ointment versus petrolatum for management of auricular wounds. Dermatol Surg 2005; 31 (06) 664-669
    CrossrefPubMedGoogle Scholar
  • 33 Trookman NS, Rizer RL, Weber T. Treatment of minor wounds from dermatologic procedures: a comparison of three topical wound care ointments using a laser wound model. J Am Acad Dermatol 2011; 64 (3, Suppl): S8-S15
    CrossrefPubMedGoogle Scholar
  • 34 Draelos ZD, Rizer RL, Trookman NS. A comparison of postprocedural wound care treatments: do antibiotic-based ointments improve outcomes?. J Am Acad Dermatol 2011; 64 (3, Suppl): S23-S29
    CrossrefPubMedGoogle Scholar
  • 35 Sheth VM, Weitzul S. Postoperative topical antimicrobial use. Dermatitis 2008; 19 (04) 181-189
    CrossrefPubMedGoogle Scholar
  • 36 Andrew R, Luecke G, Dozier S, Diven DG. A pilot study to investigate the efficacy of tobramycin-dexamethasone ointment in promoting wound healing. Dermatol Ther (Heidelb) 2012; 2 (01) 12
    CrossrefPubMedGoogle Scholar
  • 37 Lee DH, Kim DY, Yoon SY, Park HS, Yoon HS, Cho S. Retrospective clinical trial of fusidic acid versus petrolatum in the postprocedure care of clean dermatologic procedures. Ann Dermatol 2015; 27 (01) 15-20
    CrossrefPubMedGoogle Scholar
  • 38 Chen PJ, Hua YM, Toh HS, Lee MC. Topical antibiotic prophylaxis for surgical wound infections in clean and clean-contaminated surgery: a systematic review and meta-analysis. BJS Open 2021; 5 (06) zrab125
    CrossrefPubMedGoogle Scholar
  • 39 Saco M, Howe N, Nathoo R, Cherpelis B. Topical antibiotic prophylaxis for prevention of surgical wound infections from dermatologic procedures: a systematic review and meta-analysis. J Dermatolog Treat 2015; 26 (02) 151-158
    CrossrefPubMedGoogle Scholar
  • 40 Morales-Burgos A, Loosemore MP, Goldberg LH. Postoperative wound care after dermatologic procedures: a comparison of 2 commonly used petrolatum-based ointments. J Drugs Dermatol 2013; 12 (02) 163-164
    PubMedGoogle Scholar
  • 41 Sniezek PJ, Brodland DG, Zitelli JA. A randomized controlled trial comparing acetaminophen, acetaminophen and ibuprofen, and acetaminophen and codeine for postoperative pain relief after Mohs surgery and cutaneous reconstruction. Dermatol Surg 2011; 37 (07) 1007-1013
    CrossrefPubMedGoogle Scholar
  • 42 Merritt BG, Lee NY, Brodland DG, Zitelli JA, Cook J. The safety of Mohs surgery: a prospective multicenter cohort study. J Am Acad Dermatol 2012; 67 (06) 1302-1309
    CrossrefPubMedGoogle Scholar
  • 43 Harris K, Curtis J, Larsen B. et al. Opioid pain medication use after dermatologic surgery: a prospective observational study of 212 dermatologic surgery patients. JAMA Dermatol 2013; 149 (03) 317-321
    CrossrefPubMedGoogle Scholar
  • 44 Saco M, Golda N. Optimal timing of postoperative pharmacologic pain control in Mohs micrographic surgery: a prospective cohort study. J Am Acad Dermatol 2020; 82 (02) 495-497
    CrossrefPubMedGoogle Scholar
  • 45 Saco M, Golda N. Postoperative pain management in dermatologic surgery: a systematic review. Dermatol Clin 2019; 37 (03) 341-348
    CrossrefPubMedGoogle Scholar
  • 46 Eichhorn W, Kluwe L, Heiland M, Gröbe A. Lack of evidence for increased risk of postoperative bleeding after cutaneous surgery in the head and neck in patients taking aspirin. Br J Oral Maxillofac Surg 2014; 52 (06) 527-529
    CrossrefPubMedGoogle Scholar
  • 47 Eilers Jr RE, Goldenberg A, Cowan NL, Basu P, Brian Jiang SI. A retrospective assessment of postoperative bleeding complications in anticoagulated patients following Mohs micrographic surgery. Dermatol Surg 2018; 44 (04) 504-511
    CrossrefPubMedGoogle Scholar
  • 48 Otley CC, Fewkes JL, Frank W, Olbricht SM. Complications of cutaneous surgery in patients who are taking warfarin, aspirin, or nonsteroidal anti-inflammatory drugs. Arch Dermatol 1996; 132 (02) 161-166
    CrossrefPubMedGoogle Scholar
  • 49 Engheta A, Hadadi Abianeh S, Atri A, Sanatkarfar M. Aspirin use and bleeding volume in skin cancer patients undergoing surgery: a randomized controlled trial. Daru 2016; 24 (01) 20
    CrossrefPubMedGoogle Scholar
  • 50 Harbottle M, Telfer M, Hunjan PS, Knepil GJ, Singh RP. Bleeding complications in cutaneous surgery for patients on warfarin who have skin cancer of the head and neck. Br J Oral Maxillofac Surg 2014; 52 (06) 523-526
    CrossrefPubMedGoogle Scholar
  • 51 Eichhorn W, Haase M, Kluwe L. et al. Increased postoperative bleeding risk among patients with local flap surgery under continued clopidogrel therapy. BioMed Res Int 2015; 2015: 120903
    CrossrefPubMedGoogle Scholar
  • 52 Cook-Norris RH, Michaels JD, Weaver AL. et al. Complications of cutaneous surgery in patients taking clopidogrel-containing anticoagulation. J Am Acad Dermatol 2011; 65 (03) 584-591
    CrossrefPubMedGoogle Scholar
  • 53 Patel SA, Liu JJ, Murakami CS, Berg D, Akkina SR, Bhrany AD. Complication rates in delayed reconstruction of the head and neck after Mohs micrographic surgery. JAMA Facial Plast Surg 2016; 18 (05) 340-346
    CrossrefPubMedGoogle Scholar
  • 54 Miller MQ, David AP, McLean JE, Park SS, Christophel J. Association of Mohs reconstructive surgery timing with postoperative complications. JAMA Facial Plast Surg 2018; 20 (02) 122-127
    CrossrefPubMedGoogle Scholar
  • 55 David AP, Miller MQ, Park SS, Christophel JJ. Comparison of outcomes of early vs delayed graft reconstruction of Mohs micrographic surgery defects. JAMA Facial Plast Surg 2019; 21 (02) 89-94
    CrossrefPubMedGoogle Scholar
  • 56 Robinson JK, Dillig G. The advantages of delayed nasal full-thickness skin grafting after Mohs micrographic surgery. Dermatol Surg 2002; 28 (09) 845-851
    PubMedGoogle Scholar
  • 57 Majd A, Akbari A, Zloty D. Quantification of erythema associated with continuous versus interrupted nylon sutures in facial surgery repair: a randomized prospective study. Dermatol Surg 2020; 46 (06) 757-762
    CrossrefPubMedGoogle Scholar
  • 58 Blouin MM, Al Jasser M, Demanczuk A, Berkowitz J, Zloty D. Continuous versus interrupted sutures for facial surgery repair: a randomized prospective study. Dermatol Surg 2015; 41 (08) 919-928
    CrossrefPubMedGoogle Scholar
  • 59 Moran B, Humphrey S, Seal A, Berkowitz J, Zloty D. Photographic assessment of postsurgical facial scars epidermally sutured with rapidly absorbable polyglactin 910 or nylon: a randomized clinical trial. J Am Acad Dermatol 2020; 83 (05) 1395-1399
    CrossrefPubMedGoogle Scholar
  • 60 Parell GJ, Becker GD. Comparison of absorbable with nonabsorbable sutures in closure of facial skin wounds. Arch Facial Plast Surg 2003; 5 (06) 488-490
    CrossrefPubMedGoogle Scholar
  • 61 Plotner AN, Mailler-Savage E, Adams B, Gloster Jr HM. Layered closure versus buried sutures and adhesive strips for cheek defect repair after cutaneous malignancy excision. J Am Acad Dermatol 2011; 64 (06) 1115-1118
    CrossrefPubMedGoogle Scholar
  • 62 Soni A, Narula R, Kumar A, Parmar M, Sahore M, Chandel M. Comparing cyanoacrylate tissue adhesive and conventional subcuticular skin sutures for maxillofacial incisions–a prospective randomized trial considering closure time, wound morbidity, and cosmetic outcome. J Oral Maxillofac Surg 2013; 71 (12) 2152.e1-2152.e8
    CrossrefPubMedGoogle Scholar
  • 63 Burget GC, Menick FJ. The subunit principle in nasal reconstruction. Plast Reconstr Surg 1985; 76 (02) 239-247
    CrossrefPubMedGoogle Scholar
  • 64 Singh DJ, Bartlett SP. Aesthetic considerations in nasal reconstruction and the role of modified nasal subunits. Plast Reconstr Surg 2003; 111 (02) 639-648 , discussion 649–651. Doi: 3
    CrossrefPubMedGoogle Scholar
  • 65 Rohrich RJ, Griffin JR, Ansari M, Beran SJ, Potter JK. Nasal reconstruction–beyond aesthetic subunits: a 15-year review of 1334 cases. Plast Reconstr Surg 2004; 114 (06) 1405-1416 , discussion 1417–1419
    CrossrefPubMedGoogle Scholar
  • 66 Halani SH, Ma C, Pierce J, Sanniec K, Thornton JF. Nasal reconstruction after Mohs cancer resection: lessons learned from 2553 consecutive cases. Plast Reconstr Surg 2021; 148 (01) 171-182
    CrossrefPubMedGoogle Scholar
  • 67 van der Eerden PA, Lohuis PJFM, Hart AAM, Mulder WC, Vuyk H. Secondary intention healing after excision of nonmelanoma skin cancer of the head and neck: statistical evaluation of prognostic values of wound characteristics and final cosmetic results. Plast Reconstr Surg 2008; 122 (06) 1747-1755
    CrossrefPubMedGoogle Scholar
  • 68 Jacobs MA, Christenson LJ, Weaver AL. et al. Clinical outcome of cutaneous flaps versus full-thickness skin grafts after Mohs surgery on the nose. Dermatol Surg 2010; 36 (01) 23-30
    CrossrefPubMedGoogle Scholar
  • 69 Baird BJ, Moubayed SP, Most SP. A comparison of the double-half bilobe flap to the traditional bilobe flap: cohort analysis of a single surgeon experience. Facial Plast Surg 2017; 33 (05) 526-529
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 70 Monarca C, Rizzo MI, Palmieri A, Fino P, Parisi P, Scuderi N. Island pedicle and bilobed flaps in ala and back nose reconstruction: a prospective comparative analysis. Aesthetic Plast Surg 2012; 36 (05) 1168-1174
    CrossrefPubMedGoogle Scholar
  • 71 Chakraborty SS, Goel AD, Sahu RK, Midya M, Acharya S, Shakrawal N. Effectiveness of nasolabial flap versus paramedian forehead flap for nasal reconstruction: a systematic review and meta-analysis. Aesthetic Plast Surg 2022; DOI: 10.1007/s00266-022-03060-w.
    CrossrefPubMedGoogle Scholar
  • 72 Lukowiak TM, Perz AM, Veerabagu SA. et al. Patient quality of life after interpolated flap repair of nasal Mohs surgery defects: a multicenter prospective cohort study. JAMA Dermatol 2021; 157 (10) 1213-1216
    CrossrefPubMedGoogle Scholar
  • 73 Sanniec K, Malafa M, Thornton JF. Simplifying the forehead flap for nasal reconstruction: a review of 420 consecutive cases. Plast Reconstr Surg 2017; 140 (02) 371-380
    CrossrefPubMedGoogle Scholar
  • 74 Stigall LE, Bramlette TB, Zitelli JA, Brodland DG. The paramidline forehead flap: a clinical and microanatomic study. Dermatol Surg 2016; 42 (06) 764-771
    CrossrefPubMedGoogle Scholar
  • 75 Surowitz JB, Most SP. Use of laser-assisted indocyanine green angiography for early division of the forehead flap pedicle. JAMA Facial Plast Surg 2015; 17 (03) 209-214
    CrossrefPubMedGoogle Scholar
  • 76 Zenga J, Chi JJ. Reconstruction of the intranasal lining. Facial Plast Surg 2017; 33 (01) 67-73
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 77 Weber SM, Wang TD. Options for internal lining in nasal reconstruction. Facial Plast Surg Clin North Am 2011; 19 (01) 163-173
    CrossrefPubMedGoogle Scholar
  • 78 Ezzat WH, Liu SW. Comparative study of functional nasal reconstruction using structural reinforcement. JAMA Facial Plast Surg 2017; 19: 318-322
    CrossrefPubMedGoogle Scholar
  • 79 Immerman S, White WM, Constantinides M. Cartilage grafting in nasal reconstruction. Facial Plast Surg Clin North Am 2011; 19 (01) 175-182
    CrossrefPubMedGoogle Scholar
  • 80 Adams C, Ratner D. Composite and free cartilage grafting. Dermatol Clin 2005; 23 (01) 129-140 , vii
    CrossrefPubMedGoogle Scholar
  • 81 Rapstine ED, Knaus II WJ, Thornton JF. Simplifying cheek reconstruction: a review of over 400 cases. Plast Reconstr Surg 2012; 129 (06) 1291-1299
    CrossrefPubMedGoogle Scholar
  • 82 Ibrahim AMS, Rabie AN, Borud L, Tobias AM, Lee BT, Lin SJ. Common patterns of reconstruction for Mohs defects in the head and neck. J Craniofac Surg 2014; 25 (01) 87-92
    CrossrefPubMedGoogle Scholar
  • 83 Mott KJ, Clark DP, Stelljes LS. Regional variation in wound contraction of Mohs surgery defects allowed to heal by second intention. Dermatol Surg 2003; 29 (07) 712-722
    PubMedGoogle Scholar
  • 84 Nq Huynh M, Rokui S, McRae MC. An outcome comparison of superficial versus deep plane dissection of cervicofacial flaps: a systematic review and meta-analysis. J Plast Reconstr Aesthet Surg 2021; 74 (04) 730-739
    CrossrefPubMedGoogle Scholar
  • 85 Kroll SS, Reece GP, Robb G, Black J. Deep-plane cervicofacial rotation-advancement flap for reconstruction of large cheek defects. Plast Reconstr Surg 1994; 94 (01) 88-93
    CrossrefPubMedGoogle Scholar
  • 86 Huang AT, Tarasidis G, Yelverton JC, Burke A. A novel advancement flap for reconstruction of massive forehead and temple soft-tissue defects. Laryngoscope 2012; 122 (08) 1679-1684
    CrossrefPubMedGoogle Scholar
  • 87 Jacono AA, Alemi AS, Russell JL. A meta-analysis of complication rates among different SMAS facelift techniques. Aesthet Surg J 2019; 39 (09) 927-942
    CrossrefPubMedGoogle Scholar
  • 88 Jacono AA, Rousso JJ, Lavin TJ. Comparing rates of distal edge necrosis in deep-plane vs subcutaneous cervicofacial rotation-advancement flaps for facial cutaneous Mohs defects. JAMA Facial Plast Surg 2014; 16 (01) 31-35
    CrossrefPubMedGoogle Scholar
  • 89 Donigan JM, Taylor O, Greif C, Srivastava D, Nijhawan RI. Inferiorly based rotation flaps for infraorbital cheek defects. Dermatol Surg 2022; 48 (01) 61-66
    CrossrefPubMedGoogle Scholar
  • 90 Hafiji J, Hussain W, Salmon P. Mohs surgery spares the orbicularis oris muscle, optimizing cosmetic and functional outcomes for tumours in the perioral region: a series of 407 cases and reconstructions by dermatological surgeons. Br J Dermatol 2015; 172 (01) 294-296
    CrossrefPubMedGoogle Scholar
  • 91 Sanniec K, Harirah M, Thornton JF. Lip reconstruction after Mohs cancer excision: lessons learned from 615 consecutive cases. Plast Reconstr Surg 2020; 145 (02) 533-542
    CrossrefPubMedGoogle Scholar
  • 92 Godek CP, Weinzweig J, Bartlett SP. Lip reconstruction following Mohs' surgery: the role for composite resection and primary closure. Plast Reconstr Surg 2000; 106 (04) 798-804
    PubMedGoogle Scholar
  • 93 Gloster Jr HM. The use of second-intention healing for partial-thickness Mohs defects involving the vermilion and/or mucosal surfaces of the lip. J Am Acad Dermatol 2002; 47 (06) 893-897
    CrossrefPubMedGoogle Scholar
  • 94 Leonard AL, Hanke CW. Second intention healing for intermediate and large postsurgical defects of the lip. J Am Acad Dermatol 2007; 57 (05) 832-835
    CrossrefPubMedGoogle Scholar
  • 95 Becker GD, Adams LA, Levin BC. Outcome analysis of Mohs surgery of the lip and chin: comparing secondary intention healing and surgery. Laryngoscope 1995; 105 (11) 1176-1183
    CrossrefPubMedGoogle Scholar
  • 96 Sand M, Altmeyer P, Bechara FG. Mucosal advancement flap versus primary closure after vermilionectomy of the lower lip. Dermatol Surg 2010; 36 (12) 1987-1992
    CrossrefPubMedGoogle Scholar
  • 97 Sanniec K, Harirah M, Thornton JF. Ear reconstruction after Mohs cancer excision: lessons learned from 327 consecutive cases. Plast Reconstr Surg 2019; 144 (03) 719-729
    CrossrefPubMedGoogle Scholar
  • 98 Bittner GC, Kubo EM, Fantini BC, Cerci FB. Auricular reconstruction after Mohs micrographic surgery: analysis of 101 cases. An Bras Dermatol 2021; 96 (04) 408-415
    CrossrefPubMedGoogle Scholar
  • 99 Hochwalt PC, Christensen KN, Cantwell SR. et al. Comparison of full-thickness skin grafts versus second-intention healing for Mohs defects of the helix. Dermatol Surg 2015; 41 (01) 69-77
    CrossrefPubMedGoogle Scholar
  • 100 Trufant JW, Marzolf S, Leach BC, Cook J. The utility of full-thickness skin grafts (FTSGs) for auricular reconstruction. J Am Acad Dermatol 2016; 75 (01) 169-176
    CrossrefPubMedGoogle Scholar
  • 101 Quatrano NA, Dawli TB, Park AJ, Samie FH. Simplifying forehead reconstruction: a review of more than 200 cases. Facial Plast Surg 2016; 32 (03) 309-314
    Artikel in Thieme ConnectPubMedGoogle Scholar
  • 102 Wong N, Zloty D. Secondary intention healing over exposed bone on the scalp, forehead, and temple following Mohs micrographic surgery. J Cutan Med Surg 2022; 26 (03) 274-279
    CrossrefPubMedGoogle Scholar
  • 103 Becker GD, Adams LA, Levin BC. Mohs wounds of the forehead: healing by secondary intention. J Wound Care 1998; 7 (10) 497-500
    CrossrefPubMedGoogle Scholar
  • 104 Becker GD, Adams LA, Levin BC. Secondary intention healing of exposed scalp and forehead bone after Mohs surgery. Otolaryngol Head Neck Surg 1999; 121 (06) 751-754
    CrossrefPubMedGoogle Scholar
  • 105 Kannan S, Mehta D, Ozog D. Scalp closures with pulley sutures reduce time and cost compared to traditional layered technique-a prospective, randomized, observer-blinded study. Dermatol Surg 2016; 42 (11) 1248-1255
    CrossrefPubMedGoogle Scholar
  • 106 Lin MJ, Bernstein DM, Torbeck RL, Dubin DP, Rosenberg JD, Khorasani H. Botulinum toxin improves forehead scars after Mohs surgery: a randomized, double-blinded, controlled study. J Am Acad Dermatol 2022; 86 (04) 964-966
    CrossrefPubMedGoogle Scholar
  • 107 Quilichini J, Benjoar MD, Hivelin M, Lantieri L. Split-thickness skin graft harvested from the scalp for the coverage of extensive temple or forehead defects in elderly patients. Arch Facial Plast Surg 2012; 14 (02) 137-139
    CrossrefPubMedGoogle Scholar
  • 108 Schiavon M, Francescon M, Drigo D. et al. The use of Integra dermal regeneration template versus flaps for reconstruction of full-thickness scalp defects involving the calvaria: a cost-benefit analysis. Aesthetic Plast Surg 2016; 40 (06) 901-907
    CrossrefPubMedGoogle Scholar
  • 109 Maus JC, Hemal K, Khan M. et al. Dermal regeneration template and staged skin grafting for extirpative scalp wound reconstruction: a 14-year experience. Otolaryngol Head Neck Surg 2021; 165 (02) 275-281
    CrossrefPubMedGoogle Scholar
  • 110 Romano G, Bouaoud J, Moya-Plana A, Benmoussa N, Honart JF, Leymarie N. Integra® dermal regeneration template for full thickness carcinologic scalp defects: our 6 years' experience retrospective cohort and literature review. J Stomatol Oral Maxillofac Surg 2021; 122 (03) 256-262
    CrossrefPubMedGoogle Scholar
  • 111 Richardson MA, Lange JP, Jordan JR. Reconstruction of full-thickness scalp defects using a dermal regeneration template. JAMA Facial Plast Surg 2016; 18 (01) 62-67
    CrossrefPubMedGoogle Scholar
  • 112 Stebbins WG, Hanke CW, Petersen J. Human cadaveric dermal matrix for management of challenging surgical defects on the scalp. Dermatol Surg 2011; 37 (03) 301-310
    CrossrefPubMedGoogle Scholar
  • 113 Harris GJ, Garcia GH. Advancement flaps for large defects of the eyebrow, glabella, forehead, and temple. Ophthal Plast Reconstr Surg 2002; 18 (02) 138-145
    CrossrefPubMedGoogle Scholar
  • 114 Aldabagh B, Cook JL. Reconstruction of scalp wounds with exposed calvarium using a local flap and a split-thickness skin graft: case series of 20 patients. Dermatol Surg 2014; 40 (03) 257-265
    CrossrefPubMedGoogle Scholar
  • 115 Ibrahimi OA, Jih MH, Aluma-Tenorio MS, Goldberg LH, Kimyai-Asadi A. Repair of scalp defects using an H-plasty type of bilateral advancement flap. Dermatol Surg 2010; 36 (12) 1993-1997
    CrossrefPubMedGoogle Scholar
  • 116 Clark ML, Kneiber D, Neal D, Etzkorn J, Maher IA. Safety of periocular Mohs reconstruction: a two-center retrospective study. Dermatol Surg 2020; 46 (04) 521-524
    CrossrefPubMedGoogle Scholar
  • 117 Tan E, Lin F, Sheck L, Salmon P, Ng S. A practical decision-tree model to predict complexity of reconstructive surgery after periocular basal cell carcinoma excision. J Eur Acad Dermatol Venereol 2017; 31 (04) 717-723
    CrossrefPubMedGoogle Scholar
  • 118 Michelotti B, Mathis R, Roberts J, Travelute C, Billingsley E, Wilkinson M. Periorbital Mohs reconstruction: characterization of tumor histology, anatomic location, and factors influencing postoperative complications. Dermatol Surg 2014; 40 (10) 1084-1093
    CrossrefPubMedGoogle Scholar
  • 119 Kibbi N, Khan Y, Leffell DJ, Christensen SR, Suozzi KC. Predicting outcomes following second intent healing of periocular surgical defects. Arch Dermatol Res 2021; 313 (06) 483-489
    CrossrefPubMedGoogle Scholar
  • 120 Trieu DN, Drosou A, White LE, Goldberg LH. Outcomes of second intention healing of the lower eyelid margin after Mohs micrographic surgery. Dermatol Surg 2019; 45 (07) 884-889
    CrossrefPubMedGoogle Scholar
  • 121 Leibovitch I, Huilgol SC, Hsuan JD, Selva D. Incidence of host site complications in periocular full thickness skin grafts. Br J Ophthalmol 2005; 89 (02) 219-222
    CrossrefPubMedGoogle Scholar
  • 122 Rathore DS, Chickadasarahilli S, Crossman R, Mehta P, Ahluwalia HS. Full thickness skin grafts in periocular reconstructions: long-term outcomes. Ophthal Plast Reconstr Surg 2014; 30 (06) 517-520
    CrossrefPubMedGoogle Scholar
  • 123 Cannon PS, Madge SN, Kakizaki H, Selva D. Composite grafts in eyelid reconstruction: the complications and outcomes. Br J Ophthalmol 2011; 95 (09) 1268-1271
    CrossrefPubMedGoogle Scholar
  • 124 McNab AA, Martin P, Benger R, O'Donnell B, Kourt G. A prospective randomized study comparing division of the pedicle of modified Hughes flaps at two or four weeks. Ophthal Plast Reconstr Surg 2001; 17 (05) 317-319
    CrossrefPubMedGoogle Scholar
  • 125 Leibovitch I, Selva D. Modified Hughes flap: division at 7 days. Ophthalmology 2004; 111 (12) 2164-2167
    CrossrefPubMedGoogle Scholar