Erfahrungsheilkunde 2023; 72(05): 265-271
DOI: 10.1055/a-2173-6385
Wissen

Vitamin C und seine Bedeutung für die Hautgesundheit

Aline-Maria Rühtz
,
Claudia Vollbracht

Zusammenfassung

Die Haut ist unser Gewebesystem, das den Abschluss gegenüber der Außenwelt und gleichzeitig die Verbindung mit ihr bildet. Dieser faszinierende Spagat kann nur aufrechterhalten werden, wenn sehr viele Prozesse in unserem Körper Hand in Hand arbeiten. Oxidativer Stress wird als Ursache für Hautalterung und viele Hauterkrankungen verantwortlich gemacht. Vitamin C ist eines der wichtigsten physiologischen Antioxidantien und damit ein bedeutender Immunmodulator, der die Infektabwehr unterstützen und gleichzeitig überschießende Entzündungen eindämmen kann. Zudem ist der essenzielle Mikronährstoff enzymatischer Kofaktor vieler hautrelevanter Stoffwechselprozesse. Diese Eigenschaften verleihen ihm eine große Bedeutung bei der Behandlung von Hauterkrankungen und Wundheilungsstörungen (z. B. nach ästhetischen Verfahren).

Abstract

As is well known, our skin serves as the body’s outermost layer, both sealing us off from the external environment and facilitating our interaction with it. This fascinating balancing act relies on the harmonious collaboration of numerous internal processes. Oxidative stress is blamed as the cause of skin ageing and many skin diseases. Vitamin C is one of the most important physiological antioxidants and thus an important immune modulator that can support the body’s defence against infections and at the same time curb excessive inflammation. In addition, the essential micronutrient is an enzymatic co-factor of many skin-relevant metabolic processes. These properties give it great importance in the treatment of skin diseases and wound healing disorders (e. g. after aesthetic procedures).



Publication History

Article published online:
10 October 2023

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  • Literatur

  • 1 Pullar JM, Carr AC, Vissers MCM. The roles of vitamin C in skin health. Nutrients 2017; 9 (8) 866
  • 2 Godic A, Poljsak B, Adamic M. et al. The role of antioxidants in skin cancer prevention and treatment. Oxid Med Cell Longev 2014; 2014: 860479
  • 3 Pascoe. Wissenschaftliche Broschüre: Pascorbin – Die Vitamin-C-Hochdosisinfusionstherapie. 10. Aufl.. Gießen: Pascoe pharmazeutische Präparate GmbH; 2023
  • 4 Chen J, Liu Y, Zhao Z. et al. Oxidative stress in the skin: Impact and related protection. Int J Cosmet Sci 2021; 43 (5) 495-509
  • 5 Makrantonaki E, Wlaschek M, Scharffetter-Kochanek K. Pathogenesis of wound healing disorders in the elderly. J Dtsch Dermatol Ges 2017; 15 (3) 255-275
  • 6 Wölfle U, Seelinger G, Bauer G. et al. Reactive molecule species and antioxidative mechanisms in normal skin and skin aging. Skin Pharmacol Physiol 2014; 27 (6) 316-332
  • 7 Michalak M. Plant-derived antioxidants: Significance in skin health and the ageing process. Int J Mol Sci 2022; 23 (2) 585
  • 8 Fallacara A, Baldini E, Manfredini S. et al. Hyaluronic acid in the third millennium. Polymers (Basel) 2018; 10 (7) 701
  • 9 Shindo Y, Witt E, Han D. et al. Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin. J Invest Dermatol 1994; 102 (1) 122-124
  • 10 Ndiaye MA, Nihal M, Wood GS. et al. Skin, reactive oxygen species, and circadian clocks. Antioxid Redox Signal 2014; 20 (18) 2982-2996
  • 11 Frei B, England L, Ames BN. Ascorbate is an outstanding antioxidant in human blood plasma. Proc Natl Acad Sci USA 1989; 86 (16) 6377-6381
  • 12 Kishimoto Y, Saito N, Kurita K. et al. Ascorbic acid enhances the expression of type 1 and type 4 collagen and SVCT2 in cultured human skin fibroblasts. Biochem Biophys Res Commun 2013; 430 (2) 579-584
  • 13 Institute of Medicine (US) Panel on Dietary Antioxidants and Related Compounds. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington, DC: National Academic Press; 2000
  • 14 Travica N, Ried K, Hudson I. et al. The effects of surgery on plasma/serum vitamin C concentrations: A systematic review and meta-analysis. Br J Nutr 2022; 127 (2) 233-247
  • 15 Vissers MCM, Pullar JM. Re-opening old wounds: Vitamin C and wound healing deserve a re-examination. Am J Clin Nutr 2022; 115 (1) 1-2
  • 16 Moores J. Vitamin C: A wound healing perspective. Br J Community Nurs 2013; 6-11
  • 17 Mousavi S, Bereswill S, Heimesaat MM. Immunomodulatory and antimicrobial effects of vitamin C. Eur J Microbiol Immunol 2019; 9 (3) 73-79
  • 18 Abdelraheem WM, Refaie MMM, Yousef RKM. et al. Assessment of antibacterial and anti-biofilm effects of vitamin C against pseudomonas aeruginosa clinical isolates. Front Microbiol 2022; 13: 847449
  • 19 Mohammed BM, Fisher BJ, Kraskauskas D. et al. Vitamin C promotes wound healing through novel pleiotropic mechanisms. Int Wound J 2016; 13 (4) 572-584
  • 20 Rocha-Pereira P, Santos-Silva A, Rebelo I. et al. The inflammatory response in mild and in severe psoriasis. Br J Dermatol 2004; 150 (5) 917-928
  • 21 Vollbracht C, Raithel M, Krick B. et al. Intravenous vitamin C in the treatment of allergies: An interim subgroup analysis of a long-term observational study. J Int Med Res 2018; 46 (9) 3640-3655
  • 22 Hagel AF, Layritz CM, Hagel WH. et al. Intravenous infusion of ascorbic acid decreases serum histamine concentrations in patients with allergic and non-allergic diseases. Naunyn Schmied Arch Pharmacol 2013; 386 (9) 789-793
  • 23 Carr AC, Cook J. Intravenous vitamin C for cancer therapy – identifying the current gaps in our knowledge. Front Physiol 2018; 9: 1182
  • 24 Ngo B, van Riper JM, Cantley LC. et al. Targeting cancer vulnerabilities with high-dose vitamin C. Nat Rev Cancer 2019; 19 (5) 271-282
  • 25 Böttger F, Vallés-Martí A, Cahn L. et al. High-dose intravenous vitamin C: A promising multi-targeting agent in the treatment of cancer. J Exp Clin Cancer Res 2021; 40 (1) 343
  • 26 Bedhiafi T, Inchakalody VP, Fernandes Q. et al. The potential role of vitamin C in empowering cancer immunotherapy. Biomed Pharmacother 2022; 146: 112553
  • 27 Schleich T, Rodemeister S, Venturelli S. et al. Decreased plasma ascorbate levels in stage IV melanoma patients. Metab Nutr Oncol 2013; 1 (1) e2-e6
  • 28 Carr AC, Vissers MC, Cook JS. The effect of intravenous vitamin C on cancer- and chemotherapy-related fatigue and quality of life. Front Oncol 2014; 4: 283
  • 29 Vollbracht CK. Plausibility and feasibility of intravenous high-dose vitamin C in Long COVID related fatigue. J Basic Clin Pharmacy 2021; 12: 1-4
  • 30 Ou J, Zhu X, Chen P. et al. A randomized phase II trial of best supportive care with or without hyperthermia and vitamin C for heavily pretreated, advanced, refractory non-small-cell lung cancer. J Adv Res 2020; 24: 175-182
  • 31 Ou J, Zhu X, Zhang H. et al. A retrospective study of gemcitabine and carboplatin with or without intravenous vitamin C on patients with advanced triple-negative breast cancer. Integr Cancer Ther 2020; 19: 1534735419895591
  • 32 Rodríguez DM, Guerrego ME, Maldonado BM. et al. Total lymphocyte count in cancer patients with lymphopenia treated with intravenous vitamin C: Results of an observational study. Translat Med Comm 2017; 2 (1) 3
  • 33 Mayland CR, Bennett MI, Allan K. Vitamin C deficiency in cancer patients. Palliat Med 2005; 19 (1) 17-20
  • 34 Campbell EJ, Dachs GU, Morrin HR. et al. Activation of the hypoxia pathway in breast cancer tissue and patient survival are inversely associated with tumor ascorbate levels. BMC Cancer 2019; 19 (1) 307
  • 35 Blaszczak W, Barczak W, Masternak J. et al. Vitamin C as a modulator of the response to cancer therapy. Molecules 2019; 24 (3) 453
  • 36 Polireddy K, Dong J, Reed G. et al. High dose parenteral ascorbate inhibited pancreatic cancer growth and metastasis: Mechanisms and a phase I/IIa study. Sci Rep 2017; 7 (1) 17188
  • 37 Lee Chong T, Ahearn EL, Cimmino L. Reprogramming the epigenome with vitamin C. Front Cell Dev Biol 2019; 7: 128
  • 38 Nakanishi K, Hiramoto K, Sato EF. et al. High-dose vitamin C administration inhibits the invasion and proliferation of melanoma cells in mice ovary. Biol Pharm Bull 2021; 44 (1) 75-81
  • 39 Niessner H, Burkard M, Leischner C. et al. Therapeutic efficacy of pharmacological ascorbate on braf inhibitor resistant melanoma cells in vitro and in vivo. Cells 2022; 11 (7) 1229
  • 40 Bottger F, Vallés-Martí A, Cahn L. et al. High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer. J Exp Clin Cancer Res 2021; 40 (1) 343