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Synlett 2024; 35(13): 1488-1499
DOI: 10.1055/a-2181-9876
DOI: 10.1055/a-2181-9876
account
Total Synthesis of Marine Macrolide Natural Products by the Macrocyclization/Transannular Pyran Cyclization Strategy
This work was supported by the Japan Society for the Promotion of Science (JSPS KAKENHI; Grant Nos. JP17K01941 and JP22K05336) and by a Chuo University Grant for Special Research.
Abstract
In this Account, we summarize the development of a new strategy for streamlined synthesis of tetrahydropyran-embedded macrolactones and its successful implementation to a 13-step synthesis of (–)-exiguolide and an 11-step synthesis of (+)-neopeltolide.
1 Introduction
2 Development of Macrocyclization/Transannular Pyran Cyclization Strategy
3 Total Synthesis of (–)-Exiguolide
4 Total Synthesis of (+)-Neopeltolide
5 Conclusions
Publication History
Received: 02 September 2023
Accepted after revision: 26 September 2023
Accepted Manuscript online:
26 September 2023
Article published online:
02 November 2023
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See also refs. 3 and 4. For reviews, see refs. 2c, 2d, and
For synthetic studies, see:
For analogue synthesis and structure–activity relationship studies, see:
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