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Synthesis 2024; 56(14): 2263-2269
DOI: 10.1055/a-2270-0518
DOI: 10.1055/a-2270-0518
paper
Synthesis of Acyl Hydrazides and Hydrazones from Activated Amides
This study was financially supported by Chonnam National University (Grant number: 2023-0092-01).
Abstract
Acyl hydrazide and acyl hydrazone synthesis methods were developed. They involve the reaction of an activated amide with hydrazine under transition-metal-catalyst-free conditions. Additionally, acyl hydrazones were synthesized by extending the same reaction procedure in the presence of aldehydes (or ketones). These reactions were performed in an aqueous environment at 25 °C, demonstrating the successful attainment of the desired compounds with high yields.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2270-0518.
- Supporting Information
Publication History
Received: 07 January 2024
Accepted after revision: 15 February 2024
Accepted Manuscript online:
15 February 2024
Article published online:
06 March 2024
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