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Zeitschrift für Orthomolekulare Medizin 2024; 22(02): 24-27
DOI: 10.1055/a-2311-8115
Im Gespräch

Stellenwert von Selen bei Brustkrebs

Interview mit Prof. Dr. rer. nat. Lutz Schomburg
Lutz Schomburg
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Zusammenfassung

Bei verschiedenen Tumorerkrankungen ist ein Selenmangel von großer Bedeutung für die Inzidenz. Über den Einfluss des Selenstatus auf Entstehung, Genesung, Rezidivrisiko und Lebenserwartung beim Mammakarzinom sprach Herausgeber Uwe Gröber mit Prof. Dr. Schomburg von der Charité Berlin. Die labormedizinischen Messparameter und den Einsatz des Spurenelements in der Brustkrebstherapie waren ebenfalls Thema des Interviews.

Schlüsselwörter

Selen - Brustkrebs - SCAN-B - Biomarker - Inzidenz - Mortalität


Publication History

Article published online:
17 July 2024

© 2024. Thieme. All rights reserved.

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  • Literatur

  • 1 Rayman MP. Selenium and human health. Lancet 2012; 379: 1256-1268
    Google Scholar
  • 2 Hughes DJ. et al. Prediagnostic selenium status, selenoprotein gene variants and association with breast cancer risk in a European cohort study. Free Radic Biol Med 2023; 209: 381-393
    Google Scholar
  • 3 Hughes DJ. et al. Selenium status is associated with colorectal cancer risk in the European prospective investigation of cancer and nutrition cohort. Int J Cancer 2015; 136: 1149-1161
    Google Scholar
  • 4 Schomburg L, Hughes DJ. The missing link? The potential role of selenium in the development of liver cancer and significance for the general population. Expert Rev Gastroenterol Hepatol 2017; 11: 707-709
    Google Scholar
  • 5 Saal LH. et al. The Sweden Cancerome Analysis Network - Breast (SCAN-B) Initiative: a large-scale multicenter infrastructure towards implementation of breast cancer genomic analyses in the clinical routine. Genome Med 2015; 7: 20
    Google Scholar
  • 6 Hoeflich J. et al. The choice of biomarkers determines the selenium status in young German vegans and vegetarians. Br J Nutr 2010; 10411: 1601-1604
    Google Scholar
  • 7 Demircan K. et al. Serum selenium, selenoprotein P and glutathione peroxidase 3 as predictors of mortality and recurrence following breast cancer diagnosis: A multicentre cohort study. Redox Biol 2021; 47: 102145
    Google Scholar
  • 8 Schottker B. et al. Strong associations of serum selenoprotein P with all-cause mortality and mortality due to cancer, cardiovascular, respiratory and gastrointestinal diseases in older German adults. Eur J Epidemiol 2024; 39: 121-136
    Google Scholar
  • 9 Schomburg L. Selenoprotein P – Selenium transport protein, enzyme and biomarker of selenium status. Free Radic Biol Med 2022; 191: 150-163
    Google Scholar
  • 10 Sun Q. et al. Natural autoimmunity to selenoprotein P impairs selenium transport in Hashimoto's thyroiditis. Int J Mol Sci 2021; 22: 13088
    Google Scholar
  • 11 Sun Q. et al. Autoantibodies to selenoprotein P in chronic fatigue syndrome suggest selenium transport impairment and acquired resistance to thyroid hormone. Redox Biol 2023; 65: 102796
    Google Scholar
  • 12 Demircan K. et al. Autoimmunity to selenoprotein P predicts breast cancer recurrence. Redox Biol 2022; 53: 102346
    Google Scholar
  • 13 Demircan K. et al. Matched analysis of circulating selenium with the breast cancer selenotranscriptome: a multicentre prospective study. J Transl Med 2023; 21: 658
    Google Scholar
  • 14 Muecke R. et al. Selenium in radiation oncology – 15 years of experiences in Germany. Nutrients 2018; 10: 483
    Google Scholar