Subscribe to RSS
DOI: 10.1055/a-2317-6778
Solid-state mechanochemical Clemmensen reduction
Supported by: Science and Engineering Research Board SCP/2022/000352Supported by: Rashtriya Uchchatar Shiksha Abhiyan PMRF
Mechanochemical synthesis has emerged as a sustainable alternative to traditional organic reactions, offering several advantages, including reduced solvent usage, lower reaction time, lower energy consumption, and enhanced reaction efficiency. In this study, we explored the application of mechanochemistry to Clemmensen reduction, a classic method for converting aldehydes and ketones into alkanes. By employing ball milling as a mechanical activation, we demonstrate the feasibility and efficacy of mechanochemical Clemmensen reduction in various substrates. Our results indicate that this approach offers comparable or improved yields and functional group compatibility compared to conventional methods while minimizing environmental impact. The reaction optimization strategies and scope of substrates are discussed, highlighting the potential of mechanochemical synthesis for sustainable organic transformations.
Publication History
Received: 22 March 2024
Accepted after revision: 30 April 2024
Accepted Manuscript online:
30 April 2024
© . Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany