Subscribe to RSS
DOI: 10.1055/a-2381-3779
Zur Bedeutung von Selen für Sport und die Regeneration der Muskulatur
Zusammenfassung
Sport hat positive Auswirkungen auf die Muskulatur, den Metabolismus, die kognitiven Fähigkeiten und deren Erhalt. Neue präklinische Modelle und Humanstudien unterstreichen die große Bedeutung des essenziellen Spurenelements Selen und der davon abhängigen Selenoproteine, besonders für die muskuloskeletale Entwicklung, Regeneration nach Belastung, Energiebereitstellung und die positiven gesundheitlichen Wirkungen von Sport. Hierbei kommt der Expression des Selentransporters SELENOP eine Schlüsselstellung zu; ein Selen- und SELENOP-Mangel ist ein Risikofaktor für geringe Leistungsfähigkeit, fehlende positive Effekte von Sport und verzögerte Regeneration nach hoher Belastung. Allerdings darf keine übermäßige Zufuhr erfolgen, um Toxizität zu vermeiden und optimale Trainingseffekte zu erzielen.
Publication History
Article published online:
23 October 2024
© 2024. Thieme. All rights reserved.
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart,
Germany
-
Literatur
- 1 Barros D, Marques EA, Magalhães J, Carvalho J. Energy metabolism and frailty: The potential role of exercise-induced myokines – A narrative review. Ageing Res Rev 2022; 82: 101780
- 2 Ringleb M, Javelle F, Haunhorst S. et al. Beyond muscles: Investigating immunoregulatory myokines in acute resistance exercise – A systematic review and meta-analysis. Faseb J 2024; 38: e23596
- 3 Curran JE, Jowett JB, Elliott KS. et al. Genetic variation in selenoprotein S influences inflammatory response. Nat Genet 2005; 37: 1234-1241
- 4 Schomburg L. Selenoprotein P – Selenium transport protein, enzyme and biomarker of selenium status. Free Radic Biol Med 2022; 191: 150-163
- 5 Leiter O, Zhuo Z, Rust R. et al. Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging. Cell Metab 2022; 34: 408-423.e408
- 6 Jujić A, Molvin J, Nilsson ED. et al Low Levels of Selenoprotein P Are Associated With Cognitive Impairment in Patients Hospitalized for Heart Failure. J Card Fail 2024; [Online ahead of print]
- 7 Yang WS, Stockwell BR. Ferroptosis: Death by Lipid Peroxidation. Trends Cell Biol 2016; 26: 165-176
- 8 Schoenmakers E, Marelli F, Jørgensen HF. et al. Selenoprotein deficiency disorder predisposes to aortic aneurysm formation. Nat Commun 2023; 14: 7994
- 9 Hoang DH, Bouvière J, Galvis J. et al. Immune aging impairs muscle regeneration via macrophage-derived anti-oxidant selenoprotein P. bioRxiv 2024;
- 10 Schmidt MA, Jones JA, Mason CE. Optimizing human performance in extreme environments through precision medicine: From spaceflight to high-performance operations on Earth. Camb Prism Precis Med 2023; 1: e27
- 11 Morris JS, Crane SB. Selenium toxicity from a misformulated dietary supplement, adverse health effects, and the temporal response in the nail biologic monitor. Nutrients 2013; 5: 1024-1057
- 12 Wang H, Yang Z, Zhang X. et al. Antioxidants Supplementation During Exercise: Friends or Enemies for Cardiovascular Homeostasis?. J Cardiovasc Transl Res 2023; 16: 51-62
- 13 Wang X, Zhang W, Chen H. et al. High selenium impairs hepatic insulin sensitivity through opposite regulation of ROS. Toxicol Lett 2014; 224: 16-23
- 14 Dumitrescu AM, Liao XH, Abdullah MS. et al. Mutations in SECISBP2 result in abnormal thyroid hormone metabolism. Nat Genet 2005; 37: 1247-1252
- 15 Bouman K, Groothuis JT, Doorduin J. et al. SELENON-Related Myopathy Across the Life Span, a Cross-Sectional Study for Preparing Trial Readiness. J Neuromuscul Dis 2023; 10: 1055-1074
- 16 Sun Q, Oltra E, Dijck-Brouwer DAJ. et al. Autoantibodies to selenoprotein P in chronic fatigue syndrome suggest selenium transport impairment and acquired resistance to thyroid hormone. Redox Biol 2023; 65: 102796
- 17 Conrad M. Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4. Biochim Biophys Acta 2009; 1790: 1575-1585
- 18 Schöttker B, Holleczek B, Hybsier S. et al. Strong associations of serum selenoprotein P with all-cause mortality and mortality due to cancer, cardiovascular, respiratory and gastrointestinal diseases in older German adults. Eur J Epidemiol 2024; 39: 121-136