Synthesis 2025; 57(02): 441-446
DOI: 10.1055/a-2382-4650
paper
Special Topic Dedicated to Prof. H. Ila

Concise Asymmetric Synthesis of Deepoxyalchornoic Acid and (12R,13R)-Isoleukotoxin Diol

Rodney A. Fernandes 
,
Dnyaneshwar A. Gorve
,
Himanshu Papnai
This work was supported by the Science and Engineering Research Board (SERB), New Delhi (Grant No. CRG/2021/000427).
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Abstract

The first asymmetric synthesis and structural confirmation of deepoxyalchornoic acid have been accomplished from commercially available starting materials. Asymmetric dihydroxylation and Wittig olefination has been strategically executed to achieve a concise synthesis of deepoxyalchornoic acid and (12R,13R)-isoleukotoxin diol from a common intermediate chiral γ-lactone.

Key words

deepoxyalchornoic acid - (12R,13R)-isoleukotoxin diol - lactone - asymmetric dihydroxylation - Wittig olefination - natural product

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/a-2382-4650.
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Publication History

Received: 09 July 2024

Accepted after revision: 07 August 2024

Accepted Manuscript online:
07 August 2024

Article published online:
19 September 2024

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