DOI: 10.1055/s-00000084

Synthesis

Issue 04 · Volume 56 · February 2024 DOI: 10.1055/s-014-58998

editorial

III
Laha, Joydev K.; Zhou, Jianrong Steve: Synthetic Development of Key Intermediates and Active Pharmaceutical Ingredients (APIs)

table of contents

VII
Linked PDF of Table of Contents

special topic

Synthetic Development of Key Intermediates and Active Pharmaceutical Ingredients (APIs)

527
Qin, Yang; Liu, Sheng; Shi, Shi-Liang: Transition-Metal-Free Cross-Coupling of Acetals and Grignard Reagents To Form Diarylmethyl Alkyl Ethers and Triarylmethanes
https://www.thieme-connect.de/media/synthesis/202404/i_b0141_ga_10-1055_a-2088-5000.gif
Supporting Information
539
Khan, Farooq-Ahmad; Yaqoob, Sana; Qasim, Muhammad Wasim; Ali, Shujaat; Wang, Yan; Jiang, Zi-Hua: A Robust, Gram-Scale and High-Yield Synthesis of MDP Congeners for Activation of the NOD2 Receptor and Vaccine Adjuvantation
https://www.thieme-connect.de/media/synthesis/202404/i_b0528_ga_10-1055_a-2004-5883.gif
Supporting Information
549
Chaskar, Sudhir P.; Honparkhe, Ramchandra; Aghao, Arvind K.; Thorat, Rakesh G.; Pramanik, Chinmoy: An Alternative Formal Synthesis of (S)-(+)-Vigabatrin
https://www.thieme-connect.de/media/synthesis/202404/i_c0128_ga_10-1055_s-0042-1751470.gif
Supporting Information
553
Chen, Yang; Li, Qiao-Yue; Xie, Xiao-Yan; Wang, Wei; Li, Dashan; Wang, Wen-Jing; Shao, Li-Dong: Construction of an Epoxy-lactone Moiety on the C/D Ring of Highly Oxygenated Triterpenes through a Modified SeO2-Promoted Oxidative Cyclization
https://www.thieme-connect.de/media/synthesis/202404/i_c0152_ga_10-1055_a-2122-4021.gif
Supporting Information
561
Varga, Petra Regina; Belovics, Alexandra; Karaghiosoff, Konstantin; Szabó, Rita; Bősze, Szilvia; Drahos, László; Keglevich, György: Efficient Synthesis of Diethyl, Dialkyl α-Hydroxy-propylenebisphosphonates and Related 5-Phosphonoyl-1,2-oxaphospholane 2-Oxides
https://www.thieme-connect.de/media/synthesis/202404/i_c0184_ga_10-1055_a-2122-4178.gif
Supporting Information
567
Cui, Hai-Bo; Ma, Ting; Zhang, Ru-Yue; Shan, Jing; Wang, Zhong-Qiang; Bai, Mei; Chen, Yong-Zheng: Biocatalytic Synthesis of Chiral Benzylic Alcohols via Enantioselective Hydroxylation by a Self-Sufficient Cytochrome P450 from Deinococcus gobiensis
https://www.thieme-connect.de/media/synthesis/202404/i_g0096_ga_10-1055_a-2076-9792.gif
Supporting Information
573
Kumar, Kankanala Naveen; Mhate, Mouzma; Ravichandiran, Velayutham; Swain, Sharada Prasanna: Bis(pinacoloto)diboron/4-Phenylpyridine System for One-Pot Photocatalyzed Borylation and Reduction of Aldehyde: Synthesis of Tavaborole in a Flow Reactor
https://www.thieme-connect.de/media/synthesis/202404/i_g0318_ga_10-1055_a-2169-6200.gif
Supporting Information
577
Tintori, Guillaume; Jacob, Clément; Delsarte, Christine; Potié, François; Grimaud, Laurence; Vitale, Maxime; Echeverria, Pierre-Georges: Efficient and Scalable Synthesis of 6,6-Dimethyl-3-oxabicyclo [3.1.0]hexan-2-one through Organocatalyzed Desymmetrization and Chemoselective Reduction
https://www.thieme-connect.de/media/synthesis/202404/i_j0435_ga_10-1055_a-2217-0996.gif
Supporting Information
585
Bera, Shyamal Kanti; Bhanja, Rosalin; Sahu, Chandan Chittapriya; Mal, Prasenjit: An Intramolecular Radical C–N Coupling by N-Iodosuccinimide
https://www.thieme-connect.de/media/synthesis/202404/i_m0068_ga_10-1055_a-2063-0221.gif
Supporting Information
597
Nakahara, Yuichi; Endo, Yuta; Takahashi, Kazutoshi; Kawaguchi, Tomoko; Kato, Keisuke; Matsuda, Yutaka; Nagaki, Aiichiro: A Manufacturing Strategy Utilizing a Continuous-Mode Reactor toward Homogeneous PEGylated Bioconjugate Production
https://www.thieme-connect.de/media/synthesis/202404/i_m0093_ga_10-1055_a-2077-6187.gif
Supporting Information
603
Ramu, Chennam; Kumaraguru, T.; Reddy, M. Sridhar; Rode, Haridas B.; Ghosh, Subhash; Reddy, Ch. Raji; Sudhakar, Gangarajula: Synthesis of Ledipasvir through a Late-Stage Cyclopropanation and Fluorination Process
https://www.thieme-connect.de/media/synthesis/202404/i_m0494_ga_10-1055_s-0042-1751437.gif
Supporting Information
611
Sunny, Steeva; Maingle, Mohit; Sheeba, Loddipalle; Pathan, Firojkhan Rajekhan; J., Gowri Sankar; Juloori, Harika; Gadewar, Sainath Ganesh; Seth, Kapileswar: Pd-Nanoparticles-Catalyzed C(sp2)–H Arylation for the Synthesis of Functionalized Heterocycles: Recent Progress and Prospects
https://www.thieme-connect.de/media/synthesis/202404/i_r0041_ga_10-1055_a-2060-3488.gif
639
Zhang, Fei; Zhou, Yong; Wang, Shuangqiang; Zhao, Yao; Wu, Xiaojin; Chen, Rizhi: Palladium-Loading Ceramic Catalytic Membrane Reactors for Mizoroki–Heck Reaction
https://www.thieme-connect.de/media/synthesis/202404/i_b0222_ga_10-1055_a-2119-5236.gif
Supporting Information
650
Ohashi, Eisaku; Sahara, Naoto; Hirano, Yoichi; Hosoya, Masahiro; Takahashi, Yusaku; Tsuno, Naoki: An Effective Additive for Introducing the Triazole Unit of Ensitrelvir: Combination of LiCl and Et3N to Easily Generate Lithium Triazinolate
https://www.thieme-connect.de/media/synthesis/202404/i_c0088_ga_10-1055_a-2085-6342.gif
Supporting Information
657
Mahajan, Bhushan; Aand, Dnyaneshwar; Purwa, Mandeep; Mujawar, Taufiqueahmed; Ghosh, Subhash; Pabbaraja, Srihari; Singh, Ajay K.: Elements-Continuous-Flow Platform for Coupling Reactions and Anti-viral Daclatasvir API Synthesis
https://www.thieme-connect.de/media/synthesis/202404/i_c0518_ga_10-1055_a-2022-2063.gif
Supporting Information
668
Adaoudi, Omaïma; Le Bescont, Julie; Bruneau-Voisine, Antoine; Evano, Gwilherm: Copper-Catalyzed Carbonylative Cross-Coupling of Alkyl Iodides with Alcohols and Sodium Hydroxide: Synthesis of Esters and Carboxylic Acids
https://www.thieme-connect.de/media/synthesis/202404/i_m0029_ga_10-1055_a-2042-3417.gif
Supporting Information
677
Dash, Rupashri; Hota, Sudhir Kumar; Murarka, Sandip: Base-Promoted 1,6-Aza-Michael Addition of Azauracils to para-Quinone Methides
https://www.thieme-connect.de/media/synthesis/202404/i_m0215_ga_10-1055_a-2104-5943.gif
Supporting Information
686
Algera, Russell F.; Davidson, Andrew; Herbert, David K.; Lian, Yajing; Liu, Fangfang; Liu, Yiyang; Nematalla, Asaad; Piper, Jared L.; Magano, Javier; Monfette, Sebastien; Nguyen, Bao; Raggon, Jeffrey W.; Rainville, Joseph P.; Rane, Anil; Tao, Yong; Wang, Ke; Yayla, Hatice G.: Exploratory Process Development of a Pulmonary Arterial Hypertension Clinical Compound via a Late-Stage Pd-Catalyzed Buchwald–Hartwig C–N Coupling
https://www.thieme-connect.de/media/synthesis/202404/i_m0254_ga_10-1055_s-0040-1720087.gif
Supporting Information
693
Das, Soumyadip; Chanda, Kaushik: One-Pot Telescopic Approach to Synthesize Disubstituted Benz­imidazoles in Deep Eutectic Solvent
https://www.thieme-connect.de/media/synthesis/202404/i_t0135_ga_10-1055_a-2102-1192.jpg
Supporting Information

errata

700
Koswatta, Panduka B.; Sivappa, Rasapalli; Rasika Dias, H. V.; Lovely, Carl J.: Erratum - Total Synthesis of the Leucetta-Derived Alkaloid Calcaridine A