One-Pot Telescopic Approach to Synthesize Disubstituted Benz­imidazoles in Deep Eutectic Solvent

Abstract

An ongoing challenge in the pharmaceutical sector is the need to find and implement novel synthetic approaches because traditional methods sometimes violate the principles of green chemistry. While benzimidazoles are of great importance as building blocks for the creation of molecules having pharmacological activity, the development of methods for their sustainable synthesis has been a challenge for organic synthesis. Herein, we have carried out a one-pot telescopic approach to the synthesis of disubstituted benzimidazole derivatives in a deep eutectic solvent (DES) medium to investigate an alternate synthetic technique. Starting with methyl 4-fluoro-3-nitrobenzoate, S_NAr reaction, reduction, and cyclization were performed with choline chloride/glycerol/H₂O as DES medium, which gave the best performance out of the five DESs examined. We report the synthesis of disubstituted benzimidazoles via one-pot telescopic approach.

Key words

deep eutectic solvent - benzimidazole - sustainable organic synthesis - telescopic approach

Publication History

Received: 04 March 2023

Accepted after revision: 26 May 2023

Accepted Manuscript online:
26 May 2023

Article published online:
03 July 2023

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