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DOI: 10.1055/a-2435-4819
The Interesting Case

68Ga-Prostate-Specific Membrane Antigen Positron Imaging Reveals Intense Uptake in Chronic Rhinitis: A Previously Unreported Finding

Positronenbildgebung des 68Ga-prostataspezifischen Membranantigens zeigt intensive Aufnahme bei chronischer Rhinitis: Ein bisher nicht beschriebener Befund
Ahmed Saad Abdlkadir 
1   Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Amman, Jordan
,
Fatimah Abu Aljaaz
1   Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Amman, Jordan
,
Hasan Alalawi
1   Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Amman, Jordan
,
Akram Al-Ibraheem 
1   Nuclear Medicine and PET/CT, King Hussein Cancer Center (KHCC), Amman, Jordan
2   School of Medicine, University of Jordan, Amman, Jordan
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Introduction

To date, radionuclide-labeled ligands targeting prostate-specific membrane antigen (PSMA) have shown great potential for both the diagnostic and therapeutic aspects of advanced prostate cancer [Al-Ibraheem et al. Semin Nucl Med 2024. DOI: 10.1053/j.semnuclmed.2024.02.003. Online ahead of print]. The mechanism of action of this imaging technique involves the use of radiolabeled ligands that target PSMA, a glycoprotein found on prostate cancer cells [Koschel et al. Curr Opin Urol 2019; 29: 569–577]. PSMA positron emission tomography (PET) imaging has shown greater sensitivity and specificity compared to traditional methods like computed tomography (CT) scans and skeletal scintigraphy [Hofman et al. Lancet 2020; 395: 1208–1216]. However, PSMA expression is not limited to prostate cancer and can also be present in other benign and malignant conditions, leading to potential misdiagnoses [Voter et al. Semin Nucl Med 2023; 54: 119–131]. False positive results have been increasingly reported with the growing availability of PSMA agents worldwide [Voter et al. Semin Nucl Med 2023; 54: 119–131].

Through an examination of existing literature, it has been noted that there are studies detailing the presence of PSMA uptake in the nasal mucosa of both healthy individuals, and those with malignant diseases of the nasal cavity, such as juvenile nasal angiofibroma [Sakthivel et al. Clin Nucl Med 2021; 46: e398-e405, Nulent et al. Oral Surg Oral Med Oral Radiol 2018; 125: 478–486]. However, there is currently a lack of literature-based evidence regarding the localization of PSMA at the site of chronic rhinitis. Therefore, this case report presents the first reported case presented with an intensely PSMA-avid congested nasal turbinates attributed to chronic untreated rhinitis, underscoring the significance of comprehensive clinical history in identifying and addressing such diagnostic pitfall.



Publication History

Received: 08 June 2024

Accepted after revision: 07 October 2024

Article published online:
20 November 2024

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