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Am J Perinatol
DOI: 10.1055/a-2526-5326
Original Article

Sinopharm COVID-19 Vaccination during Pregnancy Triggers Thyroid Stimulating Hormone Levels in Newborns

Aylar Vatanparast
1   Infectious Diseases Research Center, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran
,
Faeze Daghigh 
2   Department of Physiology, Faculty of Medical Sciences, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran
,
Hossein Akbari
3   Department of Epidemiology and Biostatistics, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran
› Institutsangaben Funding None.
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Abstract

Objective

The effects of covid vaccination on the fetus and placenta make pregnant women a special group in the vaccination series. Coronavirus vaccines are associated with endocrine complications such as thyroid disease.

Study Design

The study included pregnant women who received the corona virus disease 2019 (COVID-19) vaccine. Pregnant women were divided into three study groups; group A (who have not received the COVID-19 vaccine), group B (who received the Sinopharm vaccine during pregnancy), and group C (who received the Sinopharm vaccine before pregnancy). Blood samples were taken to measure thyroid stimulating hormone (TSH) levels in infants 3 to 5 days old. Neonatal TSH values below 5 mU/L are considered normal.

Results

Sinopharm/BBIBP-CorV during and/or before pregnancy was associated with a slight increase in mean TSH in newborns.

Conclusion

Vaccination with Sinopharm/BBIBP-CorV during or before pregnancy may slightly increase neonatal TSH levels, but this is not clinically significant.

Key Points

  • COVID-19 vaccines linked to endocrine disruption.

  • Sinopharm CorV during pregnancy triggers TSH in infants.

  • Sinopharm vaccination in pregnancy increases neonatal TSH levels.

Keywords

COVID-19 - thyroid-stimulating hormone - Sinopharm/BBIBP-CorV

Authors' Contributions

Data collection was conducted by A.V. and F.D. Data analysis was performed by H.A. The manuscript was written by A.V. and revised by F.D. F.D. prepared the tables and figures. All authors read and approved the manuscript.




Publikationsverlauf

Eingereicht: 26. September 2024

Angenommen: 27. Januar 2025

Artikel online veröffentlicht:
06. März 2025

© 2025. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA

 

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