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Synthesis
DOI: 10.1055/a-2784-2470
Paper

An update on the total synthesis of (S)-quisqualic acid and its derivatives

Authors

  • Tomas Carny

    1   Organic chemistry, Comenius University in Bratislava Faculty of Natural Sciences, Bratislava, Slovakia (Ringgold ID: RIN164047)

  • Peter Sramel

    1   Organic chemistry, Comenius University in Bratislava Faculty of Natural Sciences, Bratislava, Slovakia (Ringgold ID: RIN164047)

  • Nela Mariana Ridzonova

    1   Organic chemistry, Comenius University in Bratislava Faculty of Natural Sciences, Bratislava, Slovakia (Ringgold ID: RIN164047)

  • Peter Kisszekelyi

    1   Organic chemistry, Comenius University in Bratislava Faculty of Natural Sciences, Bratislava, Slovakia (Ringgold ID: RIN164047)

  • Radovan Sebesta 

    1   Organic chemistry, Comenius University in Bratislava Faculty of Natural Sciences, Bratislava, Slovakia (Ringgold ID: RIN164047)

Supported by: Slovak Research and Development Agency APVV-21-0108
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(S)-Quisqualic acid and its structural analogs show potent activity across various fields of medicine. The growing interest in this amino acid family creates a pressing need for detailed synthetic procedures. Here, we present a comprehensive synthesis of N-Boc-(S)-quisqualic acid from L-serine with an overall yield of 58% over six steps. Further transformation into the C-protected (S)-quisqualic acid and the unprotected (S)-quisqualic acid HCl salt is also feasible with good yields. The complete characterization (NMR, HRMS, IR) of the intermediates and target molecules allows the reliable utilization of this synthetic work.



Publication History

Received: 17 November 2025

Accepted after revision: 08 January 2026

Accepted Manuscript online:
08 January 2026

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