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DOI: 10.1055/a-2786-3743
Carotid Body Tumors
Authors
Abstract
Carotid tumors are rare, hyper-vascular structures arising from the chemoreceptors of the carotid body. In this study, we will discuss the classification and diagnosis of carotid body tumors, as well as surgical resection, which is the definitive treatment for these lesions. We will highlight important preoperative considerations to minimize the risk of bleeding, cranial nerve injury, and stroke with surgical resection.
Keywords
carotid tumors - paraganglioma - Shamblin classification - carotid endarterectomy - carotid stentingContributors' Statement
P.B. was responsible for conceptualization, investigation, and writing, including the original draft as well as review and editing. J.L. contributed through investigation and writing, including the original draft, review, and editing. D.S. was involved in conceptualization, investigation, supervision, validation, and writing, including review and editing.
Publication History
Received: 29 December 2025
Accepted: 12 January 2026
Accepted Manuscript online:
13 January 2026
Article published online:
23 January 2026
© 2026. Thieme. All rights reserved.
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References
- 1 Gratiot JH. Carotid body tumors: collective review. 1943: 177-186
- 2 López-Barneo J. Chapter 3 - Neurobiology of the carotid body. In: Chen R, Guyenet PG. eds. Handbook of Clinical Neurology. Elsevier; 2022: 73-102
- 3 Sajid MS, Hamilton G, Baker DM. Joint Vascular Research Group. A multicenter review of carotid body tumour management. Eur J Vasc Endovasc Surg 2007; 34 (02) 127-130
- 4 Wang Y-H, Zhu J-H, Yang J. et al. The characteristics of carotid body tumors in high-altitude region: analysis from a single center. Vascular 2022; 30 (02) 301-309
- 5 Welander J, Söderkvist P, Gimm O. Genetics and clinical characteristics of hereditary pheochromocytomas and paragangliomas. Endocr Relat Cancer 2011; 18 (06) R253-R276
- 6 Antonello M, Piazza M, Menegolo M, Opocher G, Deriu GP, Grego F. Role of the genetic study in the management of carotid body tumor in paraganglioma syndrome. Eur J Vasc Endovasc Surg 2008; 36 (05) 517-519
- 7 Rinaldo A, Myssiorek D, Devaney KO, Ferlito A. Which paragangliomas of the head and neck have a higher rate of malignancy?. Oral Oncol 2004; 40 (05) 458-460
- 8 Shamblin WR, ReMine WH, Sheps SG, Harrison Jr EG. Carotid body tumor (chemodectoma). Clinicopathologic analysis of ninety cases. Am J Surg 1971; 122 (06) 732-739
- 9 Metheetrairut C, Chotikavanich C, Keskool P, Suphaphongs N. Carotid body tumor: a 25-year experience. Eur Arch Otorhinolaryngol 2016; 273 (08) 2171-2179
- 10 Luna-Ortiz K, Rascon-Ortiz M, Villavicencio-Valencia V, Herrera-Gomez A. Does Shamblin's classification predict postoperative morbidity in carotid body tumors? A proposal to modify Shamblin's classification. Eur Arch Otorhinolaryngol 2006; 263 (02) 171-175
- 11 Kim GY, Lawrence PF, Moridzadeh RS. et al. New predictors of complications in carotid body tumor resection. J Vasc Surg 2017; 65 (06) 1673-1679
- 12 Gu G, Wu X, Ji L. et al. Proposed modification to the Shamblin's classification of carotid body tumors: a single-center retrospective experience of 116 tumors. Eur J Surg Oncol 2021; 47 (08) 1953-1960
- 13 Davila VJ, Chang JM, Stone WM. et al. Current surgical management of carotid body tumors. J Vasc Surg 2016; 64 (06) 1703-1710
- 14 Tong Y. Role of duplex ultrasound in the diagnosis and assessment of carotid body tumour: a literature review. Intractable Rare Dis Res 2012; 1 (03) 129-133
- 15 Alimohamad H, Yilmaz D, Marang-van de Mheen PJ, Jansen J, Hamming JF, Schepers A. Predictors for postoperative cranial nerve complications in carotid body tumor resection: a retrospective cohort study. Int J Surg 2023; 109 (12) 4057-4061
- 16 Zeitler DM, Glick J, Har-El G. Preoperative embolization in carotid body tumor surgery: is it required?. Ann Otol Rhinol Laryngol 2010; 119 (05) 279-283
- 17 Economopoulos KP, Tzani A, Reifsnyder T. Adjunct endovascular interventions in carotid body tumors. J Vasc Surg 2015; 61 (04) 1081-91.e2
- 18 Power AH, Bower TC, Kasperbauer J. et al. Impact of preoperative embolization on outcomes of carotid body tumor resections. J Vasc Surg 2012; 56 (04) 979-989
- 19 van der Mey AGL, Jansen JC, van Baalen JM. Management of carotid body tumors. Otolaryngol Clin North Am 2001; 34 (05) 907-924 , vi
- 20 Dixon JL, Atkins MD, Bohannon WT, Buckley CJ, Lairmore TC. Surgical management of carotid body tumors: a 15-year single institution experience employing an interdisciplinary approach. Proc Bayl Univ Med Cent 2016; 29 (01) 16-20
- 21 Künzel J, Koch M, Brase C, Fietkau R, Iro H, Zenk J. Treatment of cervical paragangliomas: is surgery the only way?. Am J Otolaryngol 2014; 35 (02) 186-191