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Synlett
DOI: 10.1055/a-2797-9503
Letter

Ruthenium-catalyzed C–H Sulfonamidation of 4-Aryl-7H-pyrrolo[2,3-d] pyrimidine with Sulfonyl Azides Under Areobic Atmosphere

Authors

  • Chunfeng Li

    1   College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China (Ringgold ID: RIN12624)

  • Chenhong Pan

    1   College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China (Ringgold ID: RIN12624)

  • Bin Liu

    1   College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China (Ringgold ID: RIN12624)

  • Chunwei Shen

    1   College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China (Ringgold ID: RIN12624)

  • Xingxian Zhang 

    2   college of pharmaceutical sciences, zhejiang university of technology, hangzhou, China

Supported by: Hangzhou Keysensing Co., Ltd. KYY-HX-20241
Supported by: National Natural Science Foundation of China 22277108, 21877099
Supported by: Zhejiang Apeloa Pharmaceutical Co., Ltd. KYY-HX-20200894
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Ruthenium-catalysed arene ortho C−H sulfonamidation of 4-aryl-7H-pyrrolo[2,3-d]pyrimidine derivatives with sulfonyl azides under aerobic conditions was described. This transformation has the advantages of operational simplicity, good functional group compatibility, broad substrate scope and mild conditions, affording a variety of sulfonamidated pyrrolo[2,3-d]pyrimidine derivatives in good to excellent yields. Oxygen plays a vital role in this unique reactivity.



Publication History

Received: 19 December 2025

Accepted after revision: 26 January 2026

Accepted Manuscript online:
27 January 2026

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