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Synlett
DOI: 10.1055/a-2803-0467
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Cobalt-Catalyzed Electroreductive Cross-Coupling for the Synthesis of Atropisomeric 3-Arylindoles

Authors

  • Shi-Shuo Xu

    1   State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry Chinese Academy of Sciences, Shanghai, China (Ringgold ID: RIN58309)

  • Xin Chen

    1   State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry Chinese Academy of Sciences, Shanghai, China (Ringgold ID: RIN58309)

  • Ping Fang

    2   State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Shanghai, China

  • Tian-Sheng Mei 

    3   state key laboratory of organometallic Chemisty, Shanghai Institute of Organic Chemistry, Shanghai, China (Ringgold ID: RIN58309)

Supported by: NSF of China 22101294,22361142834,22425111
Supported by: of the Chinese Academy of Sciences XDA0540000,XDB0610000
Supported by: S&TCSM of Shanghai 21ZR1476500,25ZR1401384
Supported by: National Key R&D Program of China 2021YFA1500100
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The synthesis of atropisomeric 3-arylindoles via transition metal-catalyzed reductive cross-coupling remains challenging due to their intrinsically low rotational barriers and the comparable electronic characteristics of the two coupling partners. Herein, we present here a cobalt-catalyzed enantioselective electroreductive cross-coupling between indole bromides and aryl iodides. This method enables efficient access to atropisomeric 3-arylindoles with high chemo-and enantioselectivities. Notably, it successfully addresses the challenges posed by indole substrates lacking electron-withdrawing groups at the 2-position.



Publication History

Received: 17 November 2025

Accepted after revision: 02 February 2026

Accepted Manuscript online:
05 February 2026

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