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DOI: 10.1055/s-0028-1088369
© Georg Thieme Verlag KG Stuttgart · New York
Triterpenoid Saponins from Ardisia pusilla and their Cytotoxic Activity
Publication History
Received: July 20, 2008
Revised: September 10, 2008
Accepted: September 12, 2008
Publication Date:
27 November 2008 (online)
![](https://www.thieme-connect.de/media/plantamedica/200901/lookinside/thumbnails/10.1055-s-0028-1088369-1.jpg)
Abstract
Three new triterpenoid saponins 3, 4 and 5, together with two known saponins, ardisiacrispin B (1) and ardisiacrispin A (2), were isolated from the whole plants of Ardisia pusilla A. DC. Their structures were elucidated by extensive spectral analysis and chemical evidence. Compound 3 is a hexaglycoside with a 13,28-epoxyoleanane type aglycone, while both 4 and 5 are triterpenoid tetraglycosides related to the olean-12-ene skeleton. Saponins 1 – 4 exhibited significant cytotoxicity against human glioblastoma U251MG cells, but did not affect the growth of primary cultured human astrocytes.
Key words
Ardisia pusilla - Myrsinaceae - triterpenoid saponin - cytotoxicity - glioblastoma
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Dr. Hai-Feng Tang
Department of Pharmacy
Xijing Hospital
Fourth Military Medical University
15 Changle West Road
Xi’an 710032
People’s Republic of China
Phone: +86-29-8477-5471
Fax: +86-29-8477-5471
Email: tanghaifeng71@163.com
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