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Horm Metab Res 1975; 7(1): 70-74
DOI: 10.1055/s-0028-1093793
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© Georg Thieme Verlag KG Stuttgart · New York

Comparative Changes in Liver Composition, Acetyl-CoA and Citric Acid during Fasting in Genetically Obese Hyperglycemic Mice (ob/ob) and Lean Littermates[*]

E.  Herrera , R.  Sandler , N.  Freinkel
  • Center for Endocrinology, Metabolism and Nutrition, and Departments of Medicine and Biochemistry, Northwestern University Medical School, Chicago, Illinois, U.S.A.
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Publication Date:
23 December 2008 (online)

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Abstract

Liver mass, cellularity, composition and content of acetyl-CoA and citrate were compared in obese hyperglycemic (ob/ob) mice and their lean littermates in the fed state and following 6, 15 and 72 hr of fasting. Hepatocytes from ob/ob animals were larger and more abundant at all times although they also sustained cytoplasmic shrinkage during fasting. As judged by sequential changes in the hepatic content of regulatory metabolites, transition from the fed to the fasted state occurs more slowly during dietary deprivation in livers of ob/ob mice than in their lean littermates.

Key words

ob/ob Mice - Fasting - Liver Cellularity - Citrate - Acetyl-CoA - Hyperglycemia

1 Supported in part by research grant AM-10699 and training grant AM-05071 from the National Institutes of Arthritis and Metabolic Diseases, Bethesda, Md.

1 Supported in part by research grant AM-10699 and training grant AM-05071 from the National Institutes of Arthritis and Metabolic Diseases, Bethesda, Md.