Download PDF
Horm Metab Res 1973; 5(1): 34-37
DOI: 10.1055/s-0028-1093998
Originals

© Georg Thieme Verlag KG Stuttgart · New York

Relative Role of Cortisone and Growth Hormone on Glucose Intolerance and Insulin Secretion in Rat[*]

H. K. Åkerblom [**] , J. M. Martin , G. L. Gary
  • The Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada
Further Information

Publication History

Publication Date:
07 January 2009 (online)

Also available at
  PDF Download  Permissions and Reprints

Abstract

A comparative study on the effects of cortisone and growth hormone (GH) on the glucose tolerance and insulin secretion in the rat was made by administering cortisone acetate daily for 28 days to five control and five MtT-W15 tumor-bearing hypersomatotropic Wistar/Furth female rats. After 28 days of cortisone treatment the control rats had a diabetic type of blood glucose response to an OGTT and the typical hyperinsulinemia of steroid diabetes, whereas the hypersomatotropic rats had a normal glucose tolerance and an extreme hyperinsulinemia both fasting and after glucose stimulation. Pancreatic insulin content and islet volume were above normal in both groups. The results suggest that cortisone but not GH impairs glucose tolerance in the rat.

Key words

Cortisone Treatment - MtT-W15 Tumor - Hypersomatotropism - Diabetogenesis - Glucose Tolerance - Hyperinsulinism

1 Supported by Grant MT-1202 from the Medical Research Council of Canada

1 Supported by Grant MT-1202 from the Medical Research Council of Canada

2 Research Fellow, Medical Research Council of Canada. Present address: The Children's Hospital, University of Helsinki, Helsinki 29, Finland.

      >