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Exp Clin Endocrinol Diabetes 1986; 88(6): 257-269
DOI: 10.1055/s-0029-1210605
Original

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

The Nonenzymatic Glycation of Proteins and Nucleic Acids, Their Importance for the Development of Diabetic Complications, Possible Molecular Basis of Aging and Autoimmunological Processes

S. Krantz, Maria Lober, L. Henschel
  • Institute of Biochemistry (Director: Prof. Dr. sc. nat. H. Zühlke) of the Ernst Moritz Arndt University Greifswald/GDR
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Publication History

1986

Publication Date:
16 July 2009 (online)

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Summary

The formation of nonenzymatic glycation products of proteins and nucleic acids appears to be a link between chronic hyperglycaemia and long-term diabetic complications and special forms of aging during normoglycaemia. The major effects of extended glycation include crosslinking of glycated proteins, attachment of soluble proteins to extracellular glycated matrices, conformational changes of proteins followed by altered functions and immunogenicity, and abnormalities in nucleic acid functions.

Key words

Nonenzymatic glycation - Diabetic complications - Diabetes mellitus - Proteins - Nucleic acids - Aging - Autoantibodies