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Synthesis 2009(21): 3565-3570  
DOI: 10.1055/s-0029-1217002
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

‘Long-Range’ Pummerer-Type Cyclization: A Simple and Facile Synthesis of 5-Vinyl-1,3-oxazoles

Guangyu Xua, Kaixiong Chena, Hongwei Zhou*b
a Chemistry & Chemical Engineering College, Hunan Normal University, Changsha 410081, P. R. of China
b Department of Chemistry, Zhejiang University, (Campus Xixi), Hangzhou 310028, P. R. of China
Fax: +86(571)88920271; e-Mail: zhouhw@zju.edu.cn;
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Publication History

Received 8 May 2009
Publication Date:
08 September 2009 (online)

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Abstract

A simple and facile Pummerer cyclization for the synthesis of substituted 5-[2-(phenylthio)vinyl]-1,3-oxazoles, which are common substructures in numerous biologically active compounds, synthetic intermediates, and pharmaceuticals, has been developed.

Key words

Pummerer reaction - cyclization - vinyl-1,3-oxazoles - heterocycles - sulfoxides

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