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Synthesis 2010(1): 110-114
DOI: 10.1055/s-0029-1217085
DOI: 10.1055/s-0029-1217085
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Chemoenzymatic Synthesis of Substituted 1H-Inden-1-ones Using Lipases
Further Information
Received
30 July 2009
Publication Date:
26 October 2009 (online)
Publication History
Publication Date:
26 October 2009 (online)
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Abstract
A practical and straightforward chemoenzymatic synthesis of novel acetoxy- and hydroxy-1H-inden-1-ones starting from commercial indan-1-ones is described. By using different lipases, the final step of the preparation can be performed with high conversion working under mild reaction conditions. The desired compounds, which present a great interest since they can be employed as target substrates in enzymatic activity detection assays, were obtained in good overall yields.
Key words
enzymes - elimination - hydrolyses - ketones - fluorogenic compounds
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