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Synthesis 2010(14): 2413-2418  
DOI: 10.1055/s-0029-1218770
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Microwave-Assisted Synthesis of 4-Amino-2-arylthieno[2,3-d]pyrimidines and Their Subsequent Functionalization

Binbin Chen, Enrico Perspicace, Stéphanie Hesse*, Gilbert Kirsch
Laboratoire d’Ingénierie Moléculaire et Biochimie Pharmacologique, Institut Jean Barriol FR CNRS 2843, Université Paul Verlaine-Metz, 1 Boulevard Arago, 57070 Metz, France
Fax: +33(3)87315801; e-Mail: hesse@univ-metz.fr;
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Publication History

Received 11 March 2010
Publication Date:
05 May 2010 (online)

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Abstract

New 4-amino-2-arylthieno[2,3-d]pyrimidines were synthesized by reacting 2-amino-3-cyanothiophenes and aryl nitriles under microwave irradiation. Functionalization of 4-amino group was made by acetic anhydride and several isocyanates.

Key words

2-amino-3-cyanothiophenes - 4-amino-2-arylthi­eno[2,3-d]pyrimidines - microwave irradiation

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