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Synthesis 2010(17): 2997-3003
DOI: 10.1055/s-0030-1258182
DOI: 10.1055/s-0030-1258182
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Photoaffinity-Labeled Peptoids and Depsipeptides by Multicomponent Reactions
Further Information
Received
18 February 2010
Publication Date:
16 July 2010 (online)
Publication History
Publication Date:
16 July 2010 (online)
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Abstract
Photoaffinity tags can be incorporated easily into peptoids and congeners by the Ugi and Passerini multicomponent reactions. Products related to photo-methionine and photo-leucine can be accomplished by diazirine-containing building blocks. The same protocols can be used to synthesize derivatives with benzophenone photo cross-linkers.
Key words
photo-methionine - photo-leucine - Ugi reaction - Passerini reaction - peptoids
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