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Am J Perinatol 2011; 28(1): 067-074
DOI: 10.1055/s-0030-1262905
© Thieme Medical Publishers

Changes in Prepregnancy Body Mass Index between Pregnancies and Risk of Preterm Phenotypes

Valerie E. Whiteman1 , Kiran Rao1 , Jingyi Duan2 , Amina Alio3 , Phillip J. Marty3 , 4 , Hamisu M. Salihu1 , 2 , 4
  • 1Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, University of South Florida, Tampa, Florida
  • 2Department of Epidemiology and Biostatistics, University of South Florida, Tampa, Florida
  • 3Department of Community and Family Health, University of South Florida, Tampa, Florida
  • 4Center for Research and Evaluation, The Chiles Center, University of South Florida, Tampa, Florida
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Publication History

Publication Date:
16 July 2010 (online)

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ABSTRACT

We examined whether the risk of preterm birth and its subtypes (medically indicated and spontaneous preterm) are influenced by changes in prepregnancy body mass index (BMI) between the first and second pregnancies. A population-based, retrospective cohort analysis was performed using the Missouri (1978 to 2005) longitudinally linked cohort data sets. Women with their first two successive singleton live births (n = 436,502) were analyzed. The risks for preterm birth and its subtypes were evaluated using multivariate logistic regression modeling. Compared with women who maintained normal interpregnancy BMI, women who lowered their weight from normal to underweight were more likely to experience preterm and spontaneous preterm birth (odds ratio [OR] 1.5, 95% confidence interval [CI] 1.4 to 1.6). Women with BMI changes from normal weight to obese (OR 1.4, 95% CI 1.2 to 1.6) and normal weight to overweight (OR 1.2, 95% CI 1.1 to 1.3) were at increased risk of medically indicated preterm birth. A decrease in prepregnancy BMI from normal to underweight is associated with increased risk of spontaneous preterm birth, and prepregnancy BMI increases from normal to overweight or to obese BMI are associated with increased risk of medically indicated preterm birth.

KEYWORDS

Body mass index - preterm births - spontaneous preterm - medically indicated preterm

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Hamisu M SalihuM.D. Ph.D. 

Professor of Epidemiology, Obstetrics & Gynecology

Director, Center for Research and Evaluation; Lawton and Rhea Chiles Center for Healthy Mothers and Babies, University of South Florida, 3111 E. Fletcher Avenue, Tampa, FL 33613

Email: hamisu.salihu@gmail.com

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