Aktuelle Rheumatologie 2010; 35(4): 247-250
DOI: 10.1055/s-0030-1263200
Übersichtsarbeit

© Georg Thieme Verlag KG Stuttgart · New York

Welche Rolle spielt die Ultraschalldiagnostik beim Sjögren-Syndrom?

The Role of Ultrasound in the Diagnosis of Sjögren's SyndromeW. A. Schmidt1
  • 1Immanuel-Krankenhaus Berlin, Innere Medizin, Rheumatologie und Klinische Immunologie, Berlin, Standort Berlin-Buch
Further Information

Publication History

Publication Date:
13 September 2010 (online)

Zusammenfassung

Die Klassifikationskriterien des Sjögren-Syndroms beinhalten bisher zwar bildgebende Verfahren wie Sialografie und Szintigrafie, nicht aber die Sonografie. Die Sonografie der großen Speicheldrüsen ist einfach und rasch sowie für den Patienten angenehm durchzuführen. Es können die Linearschallköpfe verwendet werden, die dem Rheumatologen für die Gelenksonografie ohnehin zur Verfügung stehen. Eine Farbdopplersonografie verbessert die diagnostische Aussage nicht. Untersucht werden die Glandula parotis und submandibularis auf beiden Seiten. Im Falle eines Sjögren-Syndroms sind sie echoarm und inhomogen. Die Glandulae submandibularis sind häufig atrophisch (sagittaler Durchmesser <8 mm), die Glandulae parotis insbesondere bei akuten Schüben manchmal vergrößert (sagittaler Durchmesser >20 mm). Die Sensitivität der Sonografie für die Diagnose liegt zwischen 60 und 90%, die Spezifität bei deutlich über 90%. Damit ist die Sonografie ein wichtiger Baustein in der Diagnostik des Sjögren Syndroms geworden.

Abstract

The classification criteria for Sjögren's syndrome include imaging modalities such as sialography and scintigraphy, but ultrasound has not yet become part of criteria. Ultrasound of the salivary glands is a simple, cheap and quick imaging technique that is convenient for the patient. Most rheumatologists have access to ultrasound. They can apply the same linear probes that they are using for musculoskeletal ultrasound to examine the salivary glands. The use of color Doppler ultrasonography does not significantly add to the diagnosis. Ultrasound is performed on both parotid and submandibular glands. They become hypoechoic and inhomogeneous in Sjögren's syndrome. The submandibular glands are often atrophic with a sagittal diameter of <8 mm. The parotid glands are larger than normal, particularly in disease flares, with a sagittal diameter of >20 mm. The sensitivities for the diagnosis of Sjögren's syndrome range between 60 and 90%, the specificities are fair above 90%. Thus, ultrasonography has become an important tool in the diagnosis of Sjögren's syndrome.

Literatur

  • 1 Vitali C, Bombardieri S, Jonsson R. et al . Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group.  Ann Rheum Dis. 2002;  61 554-558
  • 2 Schmidt WA. Extraartikuläre Sonografie.  Akt Rheumatol. (in press)
  • 3 Bruyn GAW, Schmidt WA. Introductory guide to musculoskeletal ultrasound for the rheumatologist.. Houten, NL: Bohn Stafleu van Loghum; 2006
  • 4 Wernicke D, Hess H, Gromnica-Ihle E. et al . Ultrasonography of salivary glands – a highly specific imaging procedure for diagnosis of Sjögren's syndrome.  J Rheumatol. 2008;  35 285-293
  • 5 Kotecha S, Bhatia P, Rout PG. Diagnostic ultrasound in the head and neck region.  Dent Update. 2008;  35 533-540
  • 6 Hermann GA, Vivino FB, Goin JE. Scintigraphic features of chronic sialadenitis and Sjögren's syndrome: a comparison.  Nucl Med Commun. 1999;  20 1123-1132
  • 7 Martinez-Lazaro R, Cortez-Blanco A, Velilla J. A pilot study of the salivary scintigraphy diagnostic performance in a Spanish population with Sjögren's syndrome diagnosed by the European criteria.  Ann Rheum Dis. 2001;  60 302-303
  • 8 Kalk WW, Vissink A, Spijkervet FK. et al . Parotid sialography for diagnosing Sjögren syndrome.  Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;  94 131-137
  • 9 van den Berg I, Pijpe J, Vissink A. Salivary gland parameters and clinical data related to the underlying disorder in patients with persisting xerostomia.  Eur J Oral Sci. 2007;  115 97-102
  • 10 Makula E, Pokorny G, Kiss M. et al . The place of magnetic resonance and ultrasonographic examinations of the parotid gland in the diagnosis and follow-up of primary Sjogren's syndrome.  Rheumatology Oxford. 2000;  39 97-104
  • 11 Kamishima T. Chemical shift MR images of the parotid gland in Sjögren's syndrome utilizing low-field MR system comparison with MR sialography and salivary secretion function.  Radiation Medicine. 2005;  23 277-282
  • 12 Milic VD, Petrovic RR, Boricic IV. et al . Major salivary gland sonography in Sjögren's syndrome: diagnostic value of a novel ultrasonography score (0–12) for parenchymal inhomogeneity.  Scand J Rheumatol. 2010;  39 160-166
  • 13 Niemelä RK, Takolo R, Pääkkö E. et al . Ultrasonography of salivary glands in primary Sjögren's syndrome. A comparison with MRI and MR sialography of parotid glands.  Rheumatology. 2004;  43 875-879
  • 14 Yonetsu K, Takagi Y, Sumi M. et al . Sonography as a replacement for sialography for the diagnosis of salivary glands affected by Sjogren's syndrome.  Ann Rheum Dis. 2002;  61 276-277
  • 15 Shimizu M, Okamura K, Yoshiura K. et al . Sonographic diagnostic criteria for screening Sjogren's syndrome.  Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;  102 85-93
  • 16 Decuzzi M, Tatulli F, Giampaolo M. et al . Sialoscintigraphy versus ultrasonography of the salivary glands in patients first diagnosed with Sjogren's syndrome.  Hell J Nucl Med. 2006;  9 103-105
  • 17 de Clerck LS, Corthouts R, Francx L. et al . Ultrasonography and computer tomography of the salivary glands in the evaluation of Sjogren's syndrome. Comparison with parotid sialography.  J Rheumatol. 1988;  15 1777-1781
  • 18 De Vita S, Lorenzon G, Rossi G. et al . Salivary gland echography in primary and secondary Sjogren's syndrome.  Clin Exp Rheumatol. 1992;  10 351-356
  • 19 Ariji Y, Ohki M, Eguchi K. et al . Texture analysis of sonographic features of the parotid gland in Sjogren's syndrome.  AJR Am J Roentgenol. 1996;  166 935-941
  • 20 Makula E, Pokorny G, Rajtar M. et al . Parotid gland ultrasonography as a diagnostic tool in primary Sjogren's syndrome.  Br J Rheumatol. 1996;  35 972-977
  • 21 Salaffi F, Argalia G, Carotti M. et al . Salivary gland ultrasonography in the evaluation of primary Sjogren's syndrome. Comparison with minor salivary gland biopsy.  J Rheumatol. 2000;  27 1229-1236
  • 22 Hocevar A, Ambrozic A, Rozman B. et al . Ultrasonographic changes of major salivary glands in primary Sjogren's syndrome. Diagnostic value of a novel scoring system.  Rheumatology Oxford. 2005;  44 768-772
  • 23 El Miedany YM, Ahmed I, Mourad HG. et al . Quantitative ultrasonography and magnetic resonance imaging of the parotid gland: can they replace the histopathologic studies in patients with Sjogren's syndrome?.  Joint Bone Spine. 2004;  71 29-38
  • 24 Chikui T, Okamura K, Tokumori K. et al . Quantitative analyses of sonographic images of the parotid gland in patients with Sjogren's syndrome.  Ultrasound Med Biol. 2006;  32 617-622
  • 25 Kawamura H, Taniguchi N, Itoh K. et al . Salivary gland echography in patients with Sjogren's syndrome.  Arthritis Rheum. 1990;  33 505-510
  • 26 Takashima S, Morimoto S, Tomiyama N. et al . Sjogren syndrome: comparison of sialography and ultrasonography.  J Clin Ultrasound. 1992;  20 99-109
  • 27 Obinata K, Sato T, Ohmori K. et al . A comparison of diagnostic tools for Sjögren syndrome, with emphasis on sialography, histopathology, and ultrasonography.  Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;  109 129-134
  • 28 Carotti M, Salaffi F, Manganelli P. et al . Ultrasonography and colour doppler sonography of salivary glands in primary Sjogren's syndrome.  Clin Rheumatol. 2001;  20 213-219
  • 29 Giuseppetti GM, Argalia G, Salera D. et al . Ultrasonographic contrast-enhanced study of sicca syndrome.  Eur J Radiol. 2005;  54 225-232

Korrespondenzadresse

Prof. Dr. Wolfgang A. Schmidt

Immanuel-Krankenhaus Berlin

Innere Medizin,

Rheumatologie und Klinische Immunologie

Standort Berlin-Buch

Lindenberger Weg 19

13125 Berlin

Phone: +49/030/94792 306

Fax: +49/030/94792 550

Email: schmidt.wa@t-online.de

    >