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Exp Clin Endocrinol Diabetes 2011; 119(5): 281-285
DOI: 10.1055/s-0030-1267184
Article

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Carotid Intima-Media Thickness and Arterial Stiffness in Type 1 Diabetic Patients are Dependent on Age and Mean Blood Pressure

A. Rogowicz-Frontczak1 , A. Araszkiewicz1 , S. Pilacinski1 , D. Zozulinska-Ziolkiewicz1 , A. Wykretowicz2 , B. Wierusz-Wysocka1
  • 1Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poznan, Poland
  • 2Department of Internal Medicine, Division of Cardiology-Intensive Therapy, Poznan University of Medical Sciences, Poznan, Poland
Further Information

Publication History

received 11.06.2010 first decision 10.09.2010

accepted 15.09.2010

Publication Date:
28 October 2010 (online)

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Abstract

Aim: The aim of the study was to assess the factors that influence carotid intima-media thickness (CIMT) and arterial stiffness in type 1 diabetic patients.

Material and Methods: We included 87 type 1 diabetic patients (44 women, 43 men), median age 34 years, disease duration 10 years, HbA1c 8.2%. CIMT was measured using high resolution ultrasonography. Arterial stiffness was assessed with the use of digital volume pulse analysis and tonometric measurement of wave reflection and central haemodynamics. Serum C-reactive protein (hsCRP), matrix metalloproteinase-9 (MMP-9), soluble intracellular adhesion molecule-1 (sICAM-1) and myeloperoxidase (MPO) concentrations were also measured.

Results: CIMT and arterial stiffness correlated with age, duration of diabetes, systolic and diastolic blood pressure, GFR-glomerular filtration rate and sICAM-1. Multiple regression analysis identified only age as significant determinant of CIMT. Age, mean blood pressure and GFR, but not duration of diabetes were significant determinants of arterial stiffness.

Conclusions: In type 1 diabetic patients both CIMT and arterial stiffness were related to age, blood pressure, kidney function and sICAM-1 serum concentration.

Key words

type 1 diabetes - carotid intima-media thickness - arterial stiffness - sICAM-1

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Correspondence

A. Araszkiewicz

Department of Internal Medicine and Diabetology

Poznan University of Medical Sciences

Mickiewicza 2

60-834 Poznan

Poland

Phone: +48/61/847 4579

Fax: +48/61/847 4579

Email: olaaraszkiewicz@interia.pl