Exp Clin Endocrinol Diabetes 2011; 119(7): 440-444
DOI: 10.1055/s-0031-1275661
Article

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Comparisons of Serum Sclerostin Levels among Patients with Postmenopausal Osteoporosis, Primary Hyperparathyroidism and Osteomalacia

H. Kaji1 , 2 , Y. Imanishi3 , T. Sugimoto4 , S. Seino1 , 2
  • 1Division of Diabetes and Endocrinology, Department of Internal Medicine
  • 2Division of Cellular and Molecular Medicine, Department of Physiology and Cellular Biology, Kobe University Graduate School of Medicine
  • 3Department of Metabolism, Endocrinology & Molecular Medicine, Osaka City University Graduate School of Medicine
  • 4Internal Medicine 1, Shimane University Faculty of Medicine
Further Information

Publication History

received 22.06.2010 first decision 17.08.2010

accepted 01.10.2010

Publication Date:
10 June 2011 (online)

Abstract

Wnt-β-catenin signaling is important for bone formation. Sclerostin inhibits bone formation mainly by suppressing this signal, and several studies suggest that the suppression of sclerostin expression contributes to the bone anabolic action of parathyroid hormone (PTH). We therefore examined serum sclerostin levels using enzyme-linked immunosolvent assay in 18 patients with postmenopausal osteoporosis, 9 postmenopausal women with primary hyperparathyroidism (pHPT) and 7 patients with osteomalacia. Serum levels of sclerostin were significantly lower in the group with pHPT, compared with those with postmenopausal osteoporosis. Moreover, serum sclerostin levels were significantly lower in the group with tumor-induced osteomalacia, but not in the group with osteomalacia without tumor, compared with those with postmenopausal osteoporosis. In patients with pHPT, serum sclerostin levels were significantly and negatively correlated to serum calcium and PTH levels. In patients with postmenopausal osteoporosis, serum levels of sclerostin levels were significantly and positively related to serum calcium and creatinine levels. In conclusion, we showed that serum sclerostin levels are decreased presumably through endogenous PTH elevation in postmenopausal women with pHPT, compared with the patients with postmenopausal osteoporosis.

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Correspondence

H. Kaji

Division of Diabetes and

Endocrinology

Department of Internal

Medicine

Kobe University Graduate

School of Medicine 7–5–2

Chuo-ku Kobe 650-0017

Kusunoki-cho

Japan

Phone: + 81/72/382 5861

Fax: + 81/72/382 2080

Email: hiroshik@med.kobe-u.ac.jp