Dtsch Med Wochenschr 2011; 136(31/32): 1577-1580
DOI: 10.1055/s-0031-1281556
Hämatologie und Onkologie | Commentary
Hämatologie
© Georg Thieme Verlag KG Stuttgart · New York

Akute myeloische Leukämie: von der risikoadaptierten zur Genotyp-spezifischen Therapie

Acute myeloid leukemia: from risk-adapted to genotype-specific therapyS. Kayser1 , R. F. Schlenk1
  • 1Klinik für Innere Medizin III, Universitätsklinikum Ulm
Further Information

Publication History

Publication Date:
01 August 2011 (online)

Literatur

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  • 3 Burnett A K, Hills R K, Milligan D. et al . Identification of patients with acute myeloblastic leukemia who benefit from the addition of gemtuzumab ozogamicin: results of the MRC AML15 trial.  J Clin Oncol. 2011;  29 369-377
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  • 12 Paschka P, Schlenk R F, Gaidzik V I. et al . IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication.  J Clin Oncol. 2010;  28 3636-3643
  • 13 Schlenk R F, Döhner K, Kneba M. et al . Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with Acute Myeloid Leukemia.  Haematologica. 2009;  94 54-60
  • 14 Schlenk R F, Döhner K, Krauter J. et al . Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia.  N Engl J Med. 2008;  358 1909-1918
  • 15 Schlenk R F, Döhner K, Mack S. et al . Prospective evaluation of allogeneic hematopoietic stem-cell transplantation from matched related and matched unrelated donors in younger adults with high-risk acute myeloid leukemia: German-Austrian trial AMLHD98A.  J Clin Oncol. 2010;  28 4642-4648
  • 16 Schlenk R F, Ganser A, Döhner K. Prognostic and predictive effect of molecular and cytogenetic aberrations in acute myeloid leukemia.  ASCO Educational Book. http://www.asco.org 2010;  228-232
  • 17 Stone R M, Fischer T, Paquette R. et al . A phase 1b study of midostaurin (PKC412) in combination with daunorubicin and cytarabine induction and high-dose cytarabine consolidation in patients under age 61 with newly diagnosed de novo acute myeloid leukemia.  Blood. 2009;  114 634 (Abstract)
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PD Dr. Richard F. Schlenk

Klinik für Innere Medizin III
Universitätsklinikum Ulm

Albert-Einstein-Allee 23

89081 Ulm

Phone: 0731/500-45900

Fax: 0731/500-45905

Email: richard.schlenk@uniklinik-ulm.de

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