Nitric Oxide Release from Coumarin-7-azomethine Derivatives in the Presence of Thiol

Christos A. Kontogiorgis; Dimitra Hadjipavlou-Litina

doi:10.1055/s-0031-1296597

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Arzneimittelforschung 2007; 57(3): 143-146
DOI: 10.1055/s-0031-1296597

Analgesics · Anti-inflammatories · Antiphlogistics · Antirheumatic Drugs

Editio Cantor Verlag Aulendorf (Germany)

Nitric Oxide Release from Coumarin-7-azomethine Derivatives in the Presence of Thiol

Christos A. Kontogiorgis

¹Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Greece

,

Dimitra Hadjipavlou-Litina

¹Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, Greece

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Publication History

Publication Date:
21 December 2011 (online)

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Abstract

A series of coumarin derivatives containing a 7-azomethine linkage with anti-inflammatory activity were tested for nitric oxide release in the presence of thiol co-factors in vitro. It was found that nitric oxide release was dependent on the nature of thiol.

Key words

Anti-inflammatory drugs thiol cofactor - Coumarin - Nitric oxide donors