Synthesis 2013; 45(13): 1904-1908
DOI: 10.1055/s-0033-1338416
paper
© Georg Thieme Verlag Stuttgart · New York

A Remarkable Reductive Dearomatization of Thiophene and Furan Rings

Son T. Nguyen
Department of Chemistry, Microbiotix, Inc., One Innovation Drive, Worcester, MA 01605-4332, USA   Fax: +1(508)7571999   Email: npeet@microbiotix.com
,
Xiaoyuan Ding
Department of Chemistry, Microbiotix, Inc., One Innovation Drive, Worcester, MA 01605-4332, USA   Fax: +1(508)7571999   Email: npeet@microbiotix.com
,
Norton P. Peet*
Department of Chemistry, Microbiotix, Inc., One Innovation Drive, Worcester, MA 01605-4332, USA   Fax: +1(508)7571999   Email: npeet@microbiotix.com
› Author Affiliations
Further Information

Publication History

Received: 20 December 2012

Accepted: 17 March 2013

Publication Date:
08 May 2013 (online)


The authors would like to dedicate this work to Professor Scott Denmark on the occasion of his 60th birthday, in appreciation of his enthusiastic mentorship to young scientists, including Son Nguyen, over the years.

Abstract

Reduction of a 2-nitrothiophene 4 and the corresponding 2-nitrofuran 20 with zinc and acetic acid produced a remarkable dearomatization and fragmentation reaction to give acyclic nitriles 6 and 22, respectively. The intermediate 2-aminothiophene 5 was trapped by acylation with acetic anhydride to give acetamide 7. An additional acrylonitrile intermediate 17 was also trapped by Michael­ addition with benzyl mercaptan to give adduct 18. An alternate synthesis of nitrile 22 produced in the reduction of nitrofuran 20 provided an authentic sample of the product. The conversion of nitroaromatic heterocycles 4 and 20 into aliphatic nitriles 6 and 22 are remarkable and unprecedented reactions.

Supporting Information

 
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