Synthesis 2013; 45(17): 2447-2457
DOI: 10.1055/s-0033-1339348
paper
© Georg Thieme Verlag Stuttgart · New York

The Preparation of Various New Heterocyclic Compounds via Cyclization of Substituted Derivatives of Phenacyl Esters of Hydrazonoacetic Acid

Radek Mělnický
b   Farmak a.s., Na Vlcinci 3, 77117 Olomouc, Czech Republic   Fax: +4058231424   Email: pavel.hradil@farmak.cz
,
Martin Grepl
b   Farmak a.s., Na Vlcinci 3, 77117 Olomouc, Czech Republic   Fax: +4058231424   Email: pavel.hradil@farmak.cz
,
Antonín Lyčka
c   Research Institute for Organic Syntheses, Rybitvi 296, 533 54 Pardubice, Czech Republic
d   University of Hradec Kralove, Faculty of Science, Rokitanského 62, 500 03 Hradec Králove 3, Czech Republic
,
Valerio Bertolasi
e   Dipartimento di Chimica and Centro di Structturistica Diffrattometrica, University of Ferrara, Via L. Borsari 46, 441 00 Ferrara, Italy
,
Lubomír Kvapil
b   Farmak a.s., Na Vlcinci 3, 77117 Olomouc, Czech Republic   Fax: +4058231424   Email: pavel.hradil@farmak.cz
,
Barbora Dvořáková
b   Farmak a.s., Na Vlcinci 3, 77117 Olomouc, Czech Republic   Fax: +4058231424   Email: pavel.hradil@farmak.cz
,
Pavel Hradil*
a   Department of Organic Chemistry, Palacky University, Tr. 17. Listopadu 12, 771 46 Olomouc, Czech Republic
b   Farmak a.s., Na Vlcinci 3, 77117 Olomouc, Czech Republic   Fax: +4058231424   Email: pavel.hradil@farmak.cz
› Author Affiliations
Further Information

Publication History

Received: 12 March 2013

Accepted after revision: 10 June 2013

Publication Date:
01 August 2013 (online)


Abstract

A procedure for the preparation of derivatives of phen­acyl hydrazonopropanoates and their application in the synthesis of various heterocycles has been developed. Not only is the preparation of indole derivatives described, but also a new method for the preparation of previously unknown pyridazine derivatives.

Supporting Information

 
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