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Drug Res (Stuttg) 2014; 64(02): 91-97
DOI: 10.1055/s-0033-1353180
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Effects of Metoclopramide and Ranitidine on Survival of Flat Template McFarlane Skin Flaps in a Rat Wound Healing Model

O. Yilmaz Dilsiz
1   Histology and Embryology, Ege University Faculty of Medicine, Izmir, Turkey
,
I. Akhundzada
2   Plastic and Reconstructive Surgery, Ege University Faculty of Medicine, Izmir, Turkey
,
U. Bilkay
2   Plastic and Reconstructive Surgery, Ege University Faculty of Medicine, Izmir, Turkey
,
Y. Uyanikgil
1   Histology and Embryology, Ege University Faculty of Medicine, Izmir, Turkey
,
H. Teymur
2   Plastic and Reconstructive Surgery, Ege University Faculty of Medicine, Izmir, Turkey
,
U. Ates
1   Histology and Embryology, Ege University Faculty of Medicine, Izmir, Turkey
,
M. Baka
1   Histology and Embryology, Ege University Faculty of Medicine, Izmir, Turkey
› Author Affiliations
Further Information

Publication History

received 15 April 2013

accepted 25 July 2013

Publication Date:
11 September 2013 (online)

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Abstract

Wound healing re-provides the morphological integrity after trauma. We investigated the effects of Metoclopramide and Ranitidine on survival of flat template McFarlane skin flaps in an experimental wound healing model.

Rats (n:32) were randomly allocated in following groups: Flap control (Control), Metoclopramide(MET), Ranitidine(RAN) and Metoclopramide+Ranitidine (MET+RAN). After flap elevation, ip 10 mg/kg Ranitidin or 5 mg/kg Metoclopramide or the combination of both drugs were administered for 3 days. Next analgesia was maintained. No additional drugs were used for controls. On 10th day, whole cut skin flaps were excised, fixed in buffered formaldehyde and processed with histological techniques. Paraffine sections were stained with Hematoxylen-Eosin, Mallory-Azan and immunohistochemically with Desmin and Fibronectin and then evaluated with light microscopy.

Experimental groups showed differences for epidermal degeneration, edema, hypertrophy of the hair follicles, neutrophil infiltration and areolar degeneration. Metoclopramide or Ranitidine administration positively impacts wound healing.

This unique study emphasizes the importance of considering Metoclopramide or Ranitidine for possible adverse effects on flap survival in surgical clinics, therefore the combination of both drugs is not more effective.

Key words

plastic surgery - metoclopramide - ranitidine - histology - immunohistochemistry
 

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