Download PDF
Der Nuklearmediziner 2014; 37(02): 101-108
DOI: 10.1055/s-0034-1371847
MRT für Nuklearmediziner
© Georg Thieme Verlag KG Stuttgart · New York

PET-MRT – Ein neues Verfahren der klinischen Hybridbildgebung

PET-MRI – A Novel Device for Clinical Hybrid Imaging
L. Stegger
1   Klinik für Nuklearmedizin, Universitätsklinikum Münster
,
V. Ruhlmann
2   Klinik für Nuklearmedizin, Universitätsklinikum Essen
› Author Affiliations
Further Information

Publication History

Publication Date:
07 July 2014 (online)

Also available at
    Permissions and Reprints

Zusammenfassung

Die Kombination aus PET und MRT in einem einzigen Gerät (PET-MRT) ist die neueste Variante der bisher erfolgreichen Hybridgeräte, bestehend aus einem nuklearmedizinischen Tomografieverfahren und einer komplementären Methode mit Schwerpunkt bei der morphologischen Bildgebung. Neben Geräten für die sequentielle Daten­akquisition wie bei den bisher etablierten Hybridgeräten SPECT-CT und PET-CT sind auch erste enger integrierte Geräte für die simultane Bildaufnahme verfügbar. Die klinische Zukunft dieses hochinteressanten Verfahrens ist derzeit noch offen.

Bei der PET-MRT handelt es sich um ein hochkomplexes Verfahren. Details sowohl der technischen Entwicklung als auch des optimalen klinischen Einsatzes sind Gegenstand intensiver Forschung. Die optimale Schwächungskorrektur, die Nutzung des MRT zur Bewegungs- und Partialvolumenkorrektur der PET-Daten sowie die Entwicklung optimierter multimodaler Bildgebungsansätze mit einer effektiven und effizienten Auswahl von Bildparametern sind wichtige Fragestellungen.

Abstract

The combination of PET and MRI in a single device (PET-MRI) is the latest variant of the successful hybrid imaging approach that combines a tomographic nuclear imaging device with a complementary method with a focus on morphological imaging. In addition to devices for sequential data acquisition, similar to the established hybrid devices SPECT-CT and PET-CT, more tightly integrated systems for simultaneous imaging have started to appear on the market. The clinical future of this highly interesting imaging method is at present still unclear.

PET-MRI is a highly complex method. Details of both the technical implementation and the optimal clinical application are in the focus of intensive research. The optimal attenuation correction, the use of MRI for motion and partial volume correction of PET data as well as the development of multimodal imaging approaches with an effective and efficient choice among the imaging parameters are important issues.

Schlüsselwörter

PET-MRT - MR-PET - Hybridbildgebung

Key words

PET-MRI - MR-PET - hybrid imaging
 

  • Literatur

  • 1 Boss A, Kolb A, Hofmann M et al. Diffusion tensor imaging in a human PET/MR hybrid system. Invest Radiol 2010; 45: 270-274
    CrossrefPubMedGoogle Scholar
  • 2 Boss A, Bisdas S, Kolb A et al. Hybrid PET/MRI of intracranial masses: initial experiences and comparison to PET/CT. J Nucl Med 2010; 51: 1198-1205
    CrossrefPubMedGoogle Scholar
  • 3 Chun SY, Reese TG, Ouyang J et al. MRI-based nonrigid motion correction in simultaneous PET/MRI. J Nucl Med 2012; 53: 1284-1291
    CrossrefPubMedGoogle Scholar
  • 4 Dawood M, Büther F, Jiang X et al. Respiratory motion correction in 3-D PET data with advanced optical flow algorithms. IEEE Trans Med Imaging 2008; 27: 1164-1175
    CrossrefPubMedGoogle Scholar
  • 5 Delso G, Ziegler S. PET/MRI system design. Eur J Nucl Med Mol Imaging 2009; 36: S86-S92
    CrossrefPubMedGoogle Scholar
  • 6 Delso G, Fürst S, Jakoby B et al. Performance measurements of the Siemens mMR integrated whole-body PET/MR scanner. J Nucl Med 2011; 52: 1914-1922
    CrossrefPubMedGoogle Scholar
  • 7 Dikaios N, Izquierdo-Garcia D, Graves MJ et al. MRI-based motion correction of thoracic PET: initial comparison of acquisition protocols and correction strategies suitable for simultaneous PET/MRI systems. Eur Radiol 2012; 22: 439-446
    CrossrefPubMedGoogle Scholar
  • 8 Eiber M, Martinez-Möller A, Souvatzoglou M et al. Value of a Dixon-based MR/ PET attenuation correction sequence for the localization and evaluation of PET-positive lesions. Eur J Nucl Med Mol Imaging 2011; 38: 1691-1701
    CrossrefPubMedGoogle Scholar
  • 9 Erlandsson K, Buvat I, Pretorius PH et al. A review of partial volume correction techniques for emission tomography and their applications in neurology, cardiology and oncology. Phys Med Biol 2012; 57: R119-R159
    CrossrefPubMedGoogle Scholar
  • 10 Frullano L, Catana C, Benner T et al. Bimodal MR-PET agent for quantitative pH imaging. Angew Chem Int Ed Engl 2010; 49: 2382-2384
    CrossrefPubMedGoogle Scholar
  • 11 Hofmann M, Steinke F, Scheel V. MRI-based attenuation correction for PET/MRI: a novel approach combining pattern recognition and atlas registration. J Nucl Med 2008; 49: 1875-1883
    CrossrefPubMedGoogle Scholar
  • 12 Hudsmith LE, Neubauer S. Detection of myocardial disorders by magnetic resonance spectroscopy. Nat Clin Pract Cardiovasc Med 2008; 5: S49-S56
    CrossrefPubMedGoogle Scholar
  • 13 Judenhofer MS, Wehrl HF, Newport DF et al. Simultaneous PET-MRI: a new approach for functional and morphological imaging. Nat Med 2008; 14: 459-465
    CrossrefPubMedGoogle Scholar
  • 14 Keereman V, Fierens Y, Broux T et al. MRI-based attenuation correction for PET/MRI using ultrashort echo time sequences. J Nucl Med 2010; 51: 812-818
    CrossrefPubMedGoogle Scholar
  • 15 Kolb A, Lorenz E, Judenhofer MS et al. Evaluation of Geiger-mode APDs for PET block detector designs. Phys Med Biol 2010; 55: 1815-1832
    CrossrefPubMedGoogle Scholar
  • 16 Kolb A, Wehrl HF, Hofmann M et al. Technical performance evaluation of a human brain PET/MRI system. Eur Radiol 2012; 22: 1776-1788
    CrossrefPubMedGoogle Scholar
  • 17 Lamare F, Ledesma Carbayo MJ, Cresson T et al. List-mode-based reconstruction for respiratory motion correction in PET using non-rigid body transformations. Phys Med Biol 2007; 52: 5187-5204
    CrossrefPubMedGoogle Scholar
  • 18 Livieratos L, Stegger L, Bloomfield PM et al. Rigid-body transformation of list-mode projection data for respiratory motion correction in cardiac PET. Phys Med Biol 2005; 50: 3313-3322
    CrossrefPubMedGoogle Scholar
  • 19 Lucas A, Hawkes RC, Ansorge RE et al. Development of a combined micro-PET-MR system. IEEE Nucl Sci Symp Conf Rec 2006; 2345-2348
    PubMedGoogle Scholar
  • 20 Marsden PK, Strul D, Keevil SF et al. Simultaneous PET and NMR. Br J Radiol 2002; 75: S53-S59
    CrossrefPubMedGoogle Scholar
  • 21 Schlemmer HP, Pichler BJ, Schmand M et al. Simultaneous MR/PET imaging of the human brain: feasibility study. Radiology 2008; 248: 1028-1035
    CrossrefPubMedGoogle Scholar
  • 22 Schwenzer NF, Stegger L, Bisdas S et al. Simultaneous PET/MR imaging in a human brain PET/MR system in 50 patients--current state of image quality. Eur J Radiol 2012; 81: 3472-3478
    CrossrefPubMedGoogle Scholar
  • 23 Shao Y, Cherry SR, Farahani K et al. Development of a PET detector system compatible with MRI/NMR systems. IEEE Trans Nucl Sci 1997; 44: 1167-1171
    CrossrefPubMedGoogle Scholar
  • 24 Stegger L, Martirosian P, Schwenzer N et al. Simultaneous PET/MR imaging of the brain: feasibility of cerebral blood flow measurements with FAIR-TrueFISP arterial spin labeling MRI. Acta Radiol 2012; 53: 1066-1072
    CrossrefPubMedGoogle Scholar
  • 25 Ullisch MG, Scheins JJ, Weirich C et al. MR-based PET motion correction procedure for simultaneous MR-PET neuroimaging of human brain. PLoS One 2012; 7: e48149
    CrossrefPubMedGoogle Scholar
  • 26 Uppal R, Caravan P. Targeted probes for cardiovascular MRI. Future Med Chem 2010; 2: 451-470
    CrossrefPubMedGoogle Scholar
  • 27 Wehrl HF, Judenhofer MS, Wiehr S et al. Pare-clinical PET/MR: technological advances and new perspectives in biomedical research. Eur J Nucl Med Mol Imaging 2009; 36: S56-S68
    CrossrefPubMedGoogle Scholar
  • 28 Wu Y, Catana C, Farrell R et al. PET performance evaluation of an MR-compatible PET insert. IEEE Trans Nucl Sci 2009; 56: 574-580
    CrossrefPubMedGoogle Scholar
  • 29 Würslin C, Schmidt H, Martirosian P et al. Respiratory motion correction in oncological PET using T1-weighted MR imaging on a simultaneous whole-body PET/MR system. J Nucl Med 2013; 54: 464-471
    CrossrefPubMedGoogle Scholar
  • 30 Ziegler SI, Pichler BJ, Boening G et al. A prototype high-resolution animal positron tomograph with avalanche photodiode arrays and LSO crystals. Eur J Nucl Med 2001; 28: 136-143
    CrossrefPubMedGoogle Scholar