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Clin Colon Rectal Surg 2016; 29(04): 336-344
DOI: 10.1055/s-0036-1584088
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Serrated Polyps and Serrated Polyposis Syndrome

Jean H. Ashburn
1   Department of Colorectal Surgery, Sanford R. Weiss, MD, Center for Inherited Colorectal Neoplasia, Digestive Diseases Institute, Cleveland Clinic, Cleveland, Ohio
,
Thomas P. Plesec
2   Department of Anatomic Pathology, Cleveland Clinic, Cleveland, Ohio
,
Matthew F. Kalady
1   Department of Colorectal Surgery, Sanford R. Weiss, MD, Center for Inherited Colorectal Neoplasia, Digestive Diseases Institute, Cleveland Clinic, Cleveland, Ohio
› Author Affiliations
Further Information

Publication History

Publication Date:
21 November 2016 (online)

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Abstract

Colorectal serrated polyps are intermediate lesions in the serrated neoplastic pathway, which account for up to 30% of colorectal cancers. This pathway is biologically distinct from the adenoma-to-carcinoma sequence, with associated cancers exhibiting mutations in the BRAF oncogene, DNA promoter hypermethylation, and microsatellite instability. An evolving understanding of these unique lesions has led to the development of a more accurate classification, improved endoscopic identification, and tailored clinical management guidelines. This article reviews serrated polyps and serrated polyposis syndrome.

Keywords

serrated polyps - sessile serrated adenoma/polyp - serrated neoplasia - serrated polyposis
 

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