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Journal of Pediatric Biochemistry 2012; 02(03): 125-132
DOI: 10.1055/s-0036-1586413
Review Article
Georg Thieme Verlag KG Stuttgart – New York

Helicobacter pylori and gastric inflammation: Role of MUC1 mucin

Erik P. Lillehoj
a   Division of Pulmonology, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA
,
Wei Guang
a   Division of Pulmonology, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA
,
Hua Ding
b   Division of Gastroenterology, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA
,
Steven J. Czinn
b   Division of Gastroenterology, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA
,
Thomas G. Blanchard
b   Division of Gastroenterology, Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA
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Publication History

17 October 2012

17 October 2012

Publication Date:
01 August 2016 (online)

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Abstract

More than half of the world's population is infected with Helicobacter pylori, which is strongly linked to the development of chronic gastric inflammation (gastritis), peptic ulcer disease, and stomach cancer. However, for unknown reasons, the vast majority of infected individuals are asymptomatic beyond histologic inflammation. This review article will summarize current knowledge on the molecular mechanisms of H. pylori colonization of the gastric mucosa, with a particular focus on the biochemistry of MUC1 mucin in the host response to bacterial infection.

Keywords

Helicobacter pylori - stomach - epithelium - MUC1 mucin