Synthesis 2017; 49(08): 1834-1838
DOI: 10.1055/s-0036-1588373
paper
© Georg Thieme Verlag Stuttgart · New York

Synthesis of N-Aryl Amides by Ligand-Free Copper-Catalyzed ipso-Amidation of Arylboronic Acids with Nitriles

Yan Qiao
Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an, Shaanxi 710062, P. R. of China   Email: gqli@snnu.edu.cn   Email: fengxu@snnu.edu.cn
,
Gaoqiang Li*
Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an, Shaanxi 710062, P. R. of China   Email: gqli@snnu.edu.cn   Email: fengxu@snnu.edu.cn
,
Sha Liu
Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an, Shaanxi 710062, P. R. of China   Email: gqli@snnu.edu.cn   Email: fengxu@snnu.edu.cn
,
Yujie Yangkai
Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an, Shaanxi 710062, P. R. of China   Email: gqli@snnu.edu.cn   Email: fengxu@snnu.edu.cn
,
Jingxuan Tu
Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an, Shaanxi 710062, P. R. of China   Email: gqli@snnu.edu.cn   Email: fengxu@snnu.edu.cn
,
Feng Xu*
Key Laboratory of Macromolecular Science of Shaanxi Province, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an, Shaanxi 710062, P. R. of China   Email: gqli@snnu.edu.cn   Email: fengxu@snnu.edu.cn
› Author Affiliations
Further Information

Publication History

Received: 13 September 2016

Accepted after revision: 21 November 2016

Publication Date:
16 December 2016 (online)


Abstract

A facile copper-catalyzed ipso-amidation of arylboronic acids with nitriles has been developed. The method provides a highly efficient and economical synthesis of N-aryl amides with a broad substrate scope.

Supporting Information