Nuklearmedizin 1978; 17(04): 157-160
DOI: 10.1055/s-0037-1620685
Originalarbeiten – Original Articles
Schattauer GmbH

Myocardial Perfusion Studies - Direct Imaging of Acute Myocardial Injury with 99mTc-Pyrophosphate

Untersuchungen der niyokardialen Durchblutung - direkte Abbildung myokardialer Läsionen mit 99mTc-Pyrophosphate
J. W. Keyes Jr.
1   From the Division of Nuclear Medicine, University of Michigan Medical School, Ann Arbor, Mich., U.S.A.
› Author Affiliations
Further Information

Publication History

Publication Date:
09 January 2018 (online)

Imaging of acute myocardial injury is possible with a large number of agents. All of these agents share similar patterns of uptake in acutely injured myocardial tissue. The technique appears to be a reliable way of ruling in or out the diagnosis of acute myocardial infarction.

Die bildliche (szintigraphische) Darstellung von Myokardinfarkten ist mit einer großen Anzahl von Radionukliden bzw. radiopharmazeutischen Verbindungen möglich. Alle diese Verbindungen zeigen vergleichbare Verteilungen im Myokar-dium bei akuter Infarzierung. Die Methode erscheint zuverlässig und zeigt eine hohe Sensitivität.

 
  • References

  • 1 Batovinick H, Shames D, Lappin H. et al. Noninvasive quantitation of myocardial infarction with technetium 99m pyrophosphate. Circulation 1975; 52: 909.
  • 2 Bonte E. J, Parkey R. W, Graham K. D. et al. A new method for radionuclide imaging of myocardial infarcts. Radiology 1974; 110: 473.
  • 3 Bonte E. J, Parkey R. W, Graham K. D. et al. Distribution of several agents useful in imaging myocardial infarcts. J. nucl. Med 1975; 16: 132.
  • 4 Buja L. M, Parkey R. W, Dees J. H. et al. Morphologic correlates of technetium-99m stannous pyrophosphate imaging of acute myocardial infarcts in dogs. Circulation 1975; 52: 596.
  • 5 Campeau R. J, Gottlieb S, Chandarlapaty S. K. C. et al. Accuracy of technetium-99m labelled phosphates for detection of acute myocardial infarction. J. nucl. Med 1975; 16: 518.
  • 6 Carr E. A, Beierwaltes W. H, Patno M. E. et al. The detection of experimental myocardial infarcts by photoscanning. Amer. Heart J 1962; 64: 650.
  • 7 Carr E. A, Cafruny E. J, Beierwaltes W. H. et al. Evaluation of 203Hg-chlormerodrin in the demonstration of human myocardial infarcts by scanning. Univ. Mich. med. Bull 1965; 29: 27.
  • 8 Chiu C. L, Roelofs J. D, Go R. T. et al. Coronary angiographic and scintigraphic findings in experimental cardiac contusion. Radiology 1975; 116: 679.
  • 9 Coleman R. E, Klein M. S, Ahmed S. A. et al. Mechanisms contributing to myocardial accumulation of technetium-99m stannous pyrophosphate after coronary occlusion. Amer. J. Cardiol 1977; 39: 55.
  • 10 Agostino D. A. N , Chiga M. Mitochondrial mineralization in human myocardium. Amer. J. clin. Path 1970; 53: 820.
  • 11 Dewanjee M. K, Prince E. W. Cellular necrosis model in tissue culture: Uptake of 99mTc-tetracycline and pertechnetate ion. J. nucl. Med 1974; 15: 577.
  • 12 Dewanjee M. K, Kahn P. C. Mechanism of localization of 99mTc-labeled pyrophosphate and tetracycline in infarcted myocardium. J. nucl. Med 1976; 17: 639.
  • 13 Fink D, Dworkin H. J, Lee Y. H. Myocardial imaging of the acute infarct. Radiology 1974; 113: 449.
  • 14 Gorton R. J, Hardy L. B, McGraw B. H. et al. The selective uptake of 203Hg-chlormerodrin in experimentally produced myocardial infarcts. Amer. Heart J 1966; 72: 71.
  • 15 Holman B. L, Dewanjee M. K, Idoine J. et al. Detection and localization of experimental myocardial infarction with 99mTc-tetracycline. J. nucl. Med 1973; 14: 595.
  • 16 Holman B. K, Lesch M, Zwieman E. A. et al. Detection and sizing of acute myocardial infarcts with 99mTc(Sn) tetracycline. New Engl. J. Med 1974; 291: 159.
  • 17 Hubner P. J. B. Radioisotopic detection of experimental infarction using mercury derivatives of fluorescein. Cardiovasc. Res 1970; 4: 509.
  • 18 Keyes Jr. J. W., Orlandea N, Heetderks W. J. et al. The Hu-mongotron - a scintillation camera transaxial tomograph. J. nucl. Med 1977; 18: 381.
  • 19 Keyes Jr. J. W., Leonard P. F, Brody S. L. et al. Myocardial infarct quantification in the dog by single photon emission computed tomography. Circulation, 1978; 58: 227.
  • 20 Kramer R. J, Goldstein R. E, Hirshfeld J. W. et al. Accumulation of gallium-67 in regions of acute myocardial infarction. Amer. J. Cardiol 1974; 33: 861.
  • 21 Lewis M, Buja L. M, Saffer S. et al. Experimental infarct sizing using computer processing and a three-dimensional model. Science 1977; 197: 167.
  • 22 Lowenthal I. S, Tow D. E, Chang Y. C. Accumulation of 99mTc-polyphosphate in two squamous cell carcinomas of the lung. J. nucl. Med 1975; 16: 1021.
  • 23 Malek P, Kolc J, Zastava V. et al. Fluorescence of tetracycline analogues fixed in myocardial infarction. Cardiologia (Basel) 1963; 42: 303.
  • 24 Malek P, Ratusky J, Vavrejn B. et al. Ischaemia detecting radioactive substances for scanning cardiac and skeletal muscle. Nature 1967; 214: 1130.
  • 25 Marcus M. L, Tomanek R. J, Ehrhardt J. C. et al. Relationships between myocardial perfusion, myocardial necrosis and technetium-99m pyrophosphate uptake in dogs subjected to sudden coronary occlusion. Circulation 1976; 53: 647.
  • 26 Mehta A. N, Goldstein S, Marks D. S. et al. Technetium pyrophosphate myocardial scanning in acute myocardial infarction. Henry Ford Hosp. med. J 1977; 25: 13.
  • 27 Parkey R. W, Bonte E. J, Meyer S. L. et al. A new method for radionuclide imaging of acute myocardial infarction in humans. Circulation 1974; 50: 540.
  • 28 Parkey R. W, Bonte E. J, Stokely E. M. et al. Analysis of Tc-99m stannous pyrophosphate myocardial scintigrams in 242 patients. J. nucl. Med 1975; 16: 556.
  • 29 Perez L. A, Hoyt D. B, Freeman L. M. Localization of myocardial disorders other than infarction with 99mTc-labeled phosphate agents. J. nucl. Med 1976; 17: 241.
  • 30 Pugh B. R, Buja L. M, Parkey R. W. et al. Cardioversion and “false positive” technetium-99m stannous pyrophosphate myocardial scintigrams. Circulation 1976; 54: 399.
  • 31 Rossman D. J, Rouleau J, Strauss H. W. et al. Detection and size estimation of acute myocardial infarction using 99mTc-glu-coheptonate. J. nucl. Med 1975; 16: 980.
  • 32 Schelbert H. R, Ingwall J. S, Sybers H. D. et al. Uptake of in-farct-imaging agents in reversibly and irreversibly injured myocardium in cultured fetal mouse heart. Circulat. Res 1976; 39: 860.
  • 33 Shen A. C, Jennings R. B. Myocardial calcium and magnesium in acute ischemic injury. Amer. J. Path 1972; 67: 441.
  • 34 Soin J. S, Burdine J. A, Beal W. Myocardial localization of 99mTc-pyrophosphate without evidence of acute myocardial infarction. J. nucl. Med 1975; 16: 944.
  • 35 Stokely E. M, Buja L. M, Lewis S. E. et al. Measurement of acute myocardial infarcts in dogs with 99mTc-stannous pyrophosphate scintigrams. J. nucl. Med 1976; 17: 1.
  • 36 Weiss E. S, Ahmed S. A, Welch M. J. et al. Quantification of infarction in cross-sections of canine myocardium in vivo with positron emission transaxial tomography and 11C-palmitate. Circulation 1977; 55: 66.
  • 37 Willerson J. T, Parkey R. W, Bonte E. J. et al. Acute subendocardial myocardial infarction in patients. Its detection by technetium-99m stannous pyrophosphate myocardial scintigrams. Circulation 1975; 51: 436.
  • 38 Willerson J. T, Parkey R. W, Bonte E. J. et al. Technetium stannous pyrophosphate myocardial scintigrams in patients with chest pain of varying etiology. Circulation 1975; 51: 1046.
  • 39 Zaret B. L, DiCola V. C, Danabedian R. K. et al. Dual radionuclide study of myocardial infarction. Relationships between myocardial uptake of potassium-43, technetium-99m stannous pyrophosphate, regional myocardial blood flow and creatine Phosphokinase depletion. Circulation 1976; 53: 422.