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Nuklearmedizin 1980; 19(04): 195-199
DOI: 10.1055/s-0037-1620950
Originalarbeiten — Original Articles
Schattauer GmbH

The Effect of Repeated Injections of 99mTc-Antimony-Sulphide Colloid on the RES of the Rat — Histopathologic Study[*]

Die Wirkung wiederholter Injektionen von 99mTc-Antimonsulfat-Kolloid auf das RES der Ratte - eine histopathologische Studie
I. Kazem
1   From the Institute of Radiation Therapy and Nuclear Medizine (Director: Prof. Dr. I. Kazem), Sint Radboud Hospital, University of Nijmegen, The Netherlands
,
H. Jacobs
1   From the Institute of Radiation Therapy and Nuclear Medizine (Director: Prof. Dr. I. Kazem), Sint Radboud Hospital, University of Nijmegen, The Netherlands
,
R. Claessens
1   From the Institute of Radiation Therapy and Nuclear Medizine (Director: Prof. Dr. I. Kazem), Sint Radboud Hospital, University of Nijmegen, The Netherlands
,
J. de Jong
1   From the Institute of Radiation Therapy and Nuclear Medizine (Director: Prof. Dr. I. Kazem), Sint Radboud Hospital, University of Nijmegen, The Netherlands
› Author Affiliations
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Publication History

Received: 28 April 1980

Publication Date:
08 January 2018 (online)

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Experiments on inbred albino rats were performed to test the effect of repeated administrations of 99mTc-antimony sulphide colloid on the integrity of the RES. Experiments were carried out in two batches, one with the preformed colloid given in increasing doses, and the other with the labelled colloid in increasing doses. In all, 9 groups of animals including a control group were tested. Studies included: organ weights of liver, spleen, lungs and kidneys, histopatholo- gy, contact macroautoradiography, microautoradiography and 99mTc activity distribution in organs. Results showed no macroscopic or microscopic evidence of tissue damage after repeated injections up to a total dose of 18 mCi 99mTc, 142.2 mg PVP, and 693 μg Sb, given in 9 equivalent doses at one week intervals. It is concluded that repeated administrations of 99mTc-antimony sulphide colloid for liver scintigraphy are safe.

Untersuchungen an Albinoratten wurden zur Feststellung der Wirkung wiederholter Injektionen von 99mTc-Sb2S3-Kolloid auf die Integrität des RES durchgeführt. Insgesamt wurden 9 Tiergruppen in die Untersuchung einbezogen. Leber, Milz, Lungen und Nieren wurden gewogen; ferner wurden histopathologische, Kontakt-makroautoradiografische und microau- toradiografische Untersuchungen durchgeführt und die Organverteilung der 99mTc-Aktivität gemessen. Die Ergebnisse zeigten keine makroskopischen oder mikroskopischen Beweise für einen Gewebeschaden nach wiederholten Injektionen bis zur Gesamtdosis von 18 mCi 99mTc, 142,2 mg PVP und 693 μg Sb in 9 äquivalenten Dosen mit einem Intervall von 1 Woche. Daraus wird geschlossen, daß eine wiederholte Verabreichung von 99mTc-Sb2S3-Kolloid zur Leberszintigraphie gefahrlos ist.

* This paper is dedicated to Professor Dr. K. Scheer on the occasion of his 60th birthday.


 

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