⁵¹Cr-Bleomycin in the Diagnosis of Tumours of the Chest

Summary

⁵¹Cr-bleomycin was used for the scintigraphic diagnosis of primary and secondary tumours of the thorax. The study was based on observations in 104 patients. The scintigraphy was performed using a gamma camera coupled to an on-line computer. Active lesions were scored using a semiquantitative scale of scores 0 to 5. Images were subdivided into 222 regions considered. In 72 of these, the presence of disease was diagnosed (64 malignant, 8 non-malignant) and 150 regions were classified as free from disease. At the decision threshold of score 2, over-all sensitivity and specificity of the scintigraphic detection of malignant tumours amounted to 97 and 79%, respectively. Inflammatory changes displayed some detectable accumulation of ⁵¹Cr-bleomycin but scores attributed to these lesions did not exceed the value of 2.

Zusammenfassung

⁵¹Cr-Bleomycin wurde für die Diagnostik von primären und sekundären Tumoren des Thorax eingesetzt. Die Studie umfaßte 104 Patienten, Die Szintigraphi wurde mit einer Gammakamera und angeschlossenem on-line Computer durchgeführt. Aktive Herde wurden bewertet, indem eine semiquantitative Punktskala von 0-5 angewandt wurde. Die Bilder wurden in 222 Felder aufgeteilt. In 72 dieser Felder wurde eine Erkrankung diagnostiziert, wobei 64 bösartig und 8 gutartig waren; 150 Felder wurden als krankheitsfrei bewertet. Bei einer Entscheidungsschwelle von 2 in der Bewertungsskala betrug die Gesamt-Sensitivität 97% und die Spezifität 79% für die szintigraphische Erkennbarkeit maligner Tumoren. Entzündliche Veränderungen zeigten eine erkennbare Anreicherung von ⁵¹Cr-Bleomycin, die in der Bewertungsskala jedoch nicht den Wert von 2 überschritt.

Publication History

Received: 18 May 1984

Accepted: 10 September 1984

Publication Date:
12 January 2018 (online)

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