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Nuklearmedizin 1973; 12(03): 240-251
DOI: 10.1055/s-0038-1624827
Originalarbeiten — Original Articles — Travaux Originaux
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Studies on the Relationship between 67Ga-Citrate Accumulation and Calcium Metabolism in Tumor Cells

Etude sur la relation entre la fixation du citrate de 67 gallium et le métabolisme du calcium dans des cellules tumoralesUntersuchungen über die Beziehung zwischen 67Ga-zitrat-Aufnahme und Kalziumstoffwechsel in Tumorzellen
Leopoldo J. Anghileri   *
1   Innere Klinik und Poliklinik (Tumorforschung); Klinikum der Gesamthochschule Essen (Direktor: Prof. Dr. C. G. Schmidt)
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Publication History

Received:26 April 1973

Publication Date:
22 January 2018 (online)

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L’incorporation in vivo du citrate de gallium (67Ga) et du chlorure de calcium (45Ca) dans les cellules de la tumeur ascitique d’Ehrlich a été étudiée par la technique des “ghost cells”. Les résultats indiquent qu’à peu près 50% du 67Ga intracellulaire est incorporé par le matérial cellulaire résiduel qui ist formé principalement par des phospholipides, protéines et acides nucléiques. La relation existant entre les deux incorporations (du 67Ga et du 45Ca) est discutée.

Summary

The in vivo uptake of 67Ga-citrate and 45Ca-chloride by Ehrlich ascites tumor cells has been studied by the "ghost cells" technique. The results indicate that approximately 50% of the intracellular 67Ga is incorporated into the cellular residual material formed mainly by phospholipids, proteins and nucleic acids. The relationship between both 67Ga and 45Ca incorporations is discussed.

Die in vivo “uptake” von 67Ga-Zitrat und 45Ca-Chlorid in Ehrlich-Aszites- Tumorzellen wurde anhand der “ghost cells”-Technik untersucht. Die Ergebnisse lassen erkennen, daß annähernd 50% des intrazellulären 67Ga im zellulären Restmaterial, das hauptsächlich aus Phospholipiden, Proteinen und Nukleinsäuren besteht, gespeichert werden. Die Beziehungen zwischen 67Ga- und 45Ca- Speicherung werden diskutiert.

* This work has been partially supported by the Ministerium für Wissenschaft und Forschung des Landes Nordrhein-Westfalen.


 

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