Nervenheilkunde 2012; 31(07/08): 524-529
DOI: 10.1055/s-0038-1628238
Kinder- und Jugendpsychiatrie
Schattauer GmbH

Diagnostik, Symptomatik und Ursachen der Lese-Rechtschreibstörung

Diagnosis, symptomatology and etiology of dylsexia
G. Schulte-Körne
1   Klinik für Kinder- und Jugendpsychiatrie, Psychosomatik und Psychotherapie Klinikum der Universität München
› Author Affiliations
Further Information

Publication History

Eingegangen am: 13 October 2011

angenommen am: 05 March 2012

Publication Date:
23 January 2018 (online)

Zusammenfassung

Die Lese- und Rechtschreibstörung (LRS) gehört zu den häufigen umschriebenen Entwicklungsstörungen mit einer Prävalenz um 5%, die durch eine beeinträchtigte Lesegeschwindigkeit, -genauigkeit und vermindertes Textverständnis gekennzeichnet ist. Charakteristisch für die Rechtschreibstörung ist eine Vielzahl orthografischer Fehler, die trotz regelmäßiger schulischer Unterrichtung auftreten. Komorbid treten gehäuft ADHS, depressive Störungen und Rechenstörungen auf. Die Symptomatik bleibt meist bis ins Erwachsenenalter bestehen. Genetische Faktoren, insbesondere die identifizierten Kandidatengene und ihre Funktionen sprechen dafür, die LRS als Folge einer neuronalen Migrationsstörung aufzufassen ist. Erfolgreiche therapeutische Methoden integrieren lerntherapeutische Aspekte und die Förderung von sprachlichen und orthografischen Fähigkeiten.

Summary

Dyslexia (reading and spelling disorder) is a very common developmental disorder with a prevalence about 5%. The reading disorder is characterized by a reduced word reading speed, accuracy, and reading comprehension. Reduced orthographic knowledge combined with a high number of spelling errors is characteristic for the spelling disorder. ADHD, depression and dyscalculia are the most common comborbid disorder. Dyslexia often persists into adulthood. Genetic factors are found to be causally related to dyslexia. Based on recent findings on candidate genes and their known functions dyslexia can be regarded as a neuronal migration disorder. Effective treatments are programs that integrate specific approaches of phonological and orthographic awareness trainings and knowledge from learning intervention research.

 
  • Literatur

  • 1 Dilling H, Mombour W, Schmidt MH. Internationale Klassifikation psychischer Störungen; Weltgesundheitsorganisation. Bern: Verlag Hans Huber; 1991
  • 2 Paulesu E. et al. Dyslexia: Cultural diversity and biological unity. Science 2001; 291 5511 2165.
  • 3 Ho CSH, Chan DWO, Lee SH, Tsang SM, Luan VH. Cognitive profiling and preliminary subtyping in Chinese developmental dyslexia. Cognition 2004; 91: 43-75.
  • 4 Schulte-Körne G. et al. Follow-up of a sample of children with reading-spelling disorders in adulthood. Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie 2003; 31 (04) 267-76.
  • 5 Schulte-Körne G. Diagnostik und Therapie der Lese-Rechtschreib-Störung. Deutsches Ärzteblatt 2010; 107 (41) 718-27.
  • 6 Saß H. et al. Dia-gnostische Kriterien – DSM-IV. Göttingen: Hogrefe; 1998
  • 7 Schulte-Korne G, Deimel W, Remschmidt H. Diagnosis of reading and spelling disorder. Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie 2009; 29 (02) 113-6.
  • 8 Schulte-Körne G. Lese- und Rechtschreibstörung im Schulalter. Neuropsychologische Aspekte; Themenschwerpunkt. Zeitschrift für Psychiatrie, Psychologie und Psychotherapie 2011; 59 (01) 47-55.
  • 9 Ziegler JC. et al. Developmental dyslexia in different languages: Language-specific or universal?. J Experimental Child Psychology 2003; 86: 169-93.
  • 10 De Luca M. et al. Reading words and pseudowords: An eye movement study of developmental dyslexia. Brain and language 2002; 80 (03) 617-26.
  • 11 De Luca M. et al. Eye movement patterns in linguistic and non-linguistic tasks in developmental surface dyslexia. Neuropsychologia 1999; 37: 1407-20.
  • 12 Hellwig-Brida S. et al. Intelligenz- und Aufmerksamkeitsleistungen von Jungen mit ADHS. Zeitsch-rift für Psychiatrie, Psychologie und Psychotherapie 2010; 58 (04) 299-308.
  • 13 Schulte-Körne G. The prevention, diagnosis, and treatment of dyslexia. Dtsch Arztebl Int 2010; 107 (41) 718-26.
  • 14 Thomé G, Thomé D. Oldenburger Fehleranalyse OLFA. Instrument und Handbuch zur Ermittlung der orthographischen Kompetenz ab Klasse 3 und zur Qualitätssicherung von Fördermaßnahmen. Oldenburg: Igel Verlag; 2004
  • 15 Remschmidt H, Schmidt M, Poustka F. Multiaxiales Klassifikationsschema für psychische Störungen des Kindes- und Jugendalters nach ICD-10 der WHO. 2006
  • 16 Landerl K. et al. Dyslexia and dyscalculia: Two learning disorders with different cognitive profiles. Journal of experimental child psychology 2009; 103: 309-24.
  • 17 Landerl K, Moll L. Comorbidity of learning disorders: prevalence and familial transmission. Journal of Child Psychology and Psychiatry 2010; 51 (03) 287-94.
  • 18 Daniel SS. et al. Suicidality, school dropout and reading problems among adolescents. Journal of Learning Disabilities 2006; 39 (06) 507-14.
  • 19 Goldston DB. et al. Reading problems, psychiatric disorders, and functional impairment from mid- to late adolescence. Journal of the American Academy of Child & Adolescent Psychiatry 2007; 46 (01) 25-32.
  • 20 Shaywitz SE. et al. Prevalence of reading disability in boys and girls. Results of the Connecticut Longitudinal Study. 1990: 998-1002.
  • 21 Flannery KA, Liederman J, Daly L, Schultz J. Male prevalence for reading disability is found in a large sample of black and white children free from ascertainment bias. J Am Medical Association 1990; 264 (08) 998-1002.
  • 22 Shaywitz SE. et al. Persistence of dyslexia: the Connecticut Longitudinal Study at adolescence. Pediatrics 1999; 104 (06) 1351-9.
  • 23 Strehlow U, Kluge R, Moller H, Haffner J. Der lang-fristige Verlauf der Legasthenie uber die Schulzeit hinaus: Katamnesen aus einer Kinderpsychiatrischen Ambulanz. Zeitschrift für Kinder und Jugendpsychiatrie 1992; 20 (04) 254-65.
  • 24 Esser G, Wyschkon A, Schmidt MH. Was wird aus Achtjährigen mit einer Lese-Rechtschreibstörung. Ergebnisse im Alter von 25 Jahren. Zeitschrift für Klinische Psychologie und Psychotherapie 2002; 31 (04) 235-42.
  • 25 Esser G, Wyschkon A, Schmidt MH. Was wird aus Achtjährigen mit einer Lese- und Rechtschreibstö-rung?. Z Klin Psychol Psychiat 2002; 31: 235-42.
  • 26 Schulte-Körne G. et al. Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie. 2003 31(4): 267-76.
  • 27 Bruck M. Persistence of Dyslexics’ Phonological Awareness Deficits. Developmental Psychology 1992; 28 (05) 874-86.
  • 28 Felton RH, Naylor CE, Wood FB. Neuropsychological profile of adult dyslexics. Brain and language 1990; 39: 485-97.
  • 29 Scerri T, Schulte-Körne G. Genetics of developmental dyslexia. European Child and Adolescent Psychiatry 2010; 19 (03) 179-97.
  • 30 Ziegler A. et al. Developmental dyslexia – recurrence risk estimates from a german bi-center study using the single proband sib pair design. Human heredity 2005; 59 (03) 136-43.
  • 31 Nothen MM. et al. Genetic linkage analysis with dyslexia: evidence for linkage of spelling disability to chromosome 15. European child & adolescent psychiatry 1999; 8 Suppl 3: 56-9.
  • 32 Galaburda AM. et al. From genes to behavior in developmental dyslexia. Nat Neurosci 2006; 9 (10) 1213-7.
  • 33 Burbridge TJ. et al. Postnatal analysis of the effect of embryonic knockdown and overexpression of candidate dyslexia susceptibility gene DCDC2. Neuroscience 2008; 152 (03) 723-33.
  • 34 Schulte-Korne G. et al. Interrelationship and familiarity of dyslexia related quantitative measures. Annals of human genetics 2007; 71 Pt 2 160-75.
  • 35 Schulte-Körne G, el Sharkawy J. Clinicla neurophysiology of Dyslexia. 2010 121 1794-809.
  • 36 Schulte-Körne G, Deimel W, Bartling J, Remschmidt H. Auditory processing and dyslexia: Evidence for a specific speech processing deficit. Neuroreport 1998; 9 (02) 337-40.
  • 37 Schulte-Körne G. et al. The role of phonological awareness, speech perception, and auditory temporal processing for dyslexia. European child & adolescent psychiatry 1999; 8 Suppl 3: 28-34.
  • 38 Bruder J. et al. Children with dyslexia reveal abnormal native language representations: Evidence from a study of mismatch negativity. Psychophysiology 2011; 48: 1107-18.
  • 39 Schulte-Körne G, Bruder J. Clinical neurophysiology of visual and auditory processing in dyslexia: a review. Clinical Neurophysiology 2010; 121 (11) 1794-809.
  • 40 Czamara D. et al. Association of a rare variant with mismatch negativity in a region between KIAA0319 and DCDC2 in Dyslexia. Behav Genet 2011; 41: 110-9.
  • 41 Roeske D. et al. First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children. Molecular Psychiatry 2011; 16: 97-107.
  • 42 Schulte-Körne G. et al. Familial aggregation of spelling disability. Journal of Child Psychology and Psychiatry and Allied Disciplines 1996; 37 (07) 817-22.
  • 43 Snowling M, Bishop DVM, Stothard SE. Is pre-school language impairment a risk factor for dyslexia in adolescence?. Journal of Child Psychology and Psychiatry 2000; 41: 587-600.
  • 44 Lyytinen H. et al. Early identification and prevention of dyslexia: results from a prospective follow-up study of children at familial risk for dyslexia. The Sage Handbook for Dyslexia. 2008: 121-145.
  • 45 Schneider W, Ennemoser M, Roth E, Küspert P. Kindergarten prevention of dyslexia: does training in phonological awareness work for everybody?. Journal of Learning Disabilities. 1999 32(5).
  • 46 Rückert EM. et al. Prävention von Lese-Rechtschreibschwierigkeiten. Kindheit und Entwicklung 2010; 19 (02) 82-9.
  • 47 Ise E, Engel RR, Schulte-Körne G. Was hilft bei der Lese-Rechtschreibstörung? Ergebnisse einer Meta-Analyse zur wirksamkeit deutschsprachiger Förderansätze. Kindheit und Entwicklung 2012; 21 (02) 122-36.
  • 48 Hannula-Jouppi K. et al. The axon guidance receptor gene ROBO1 is a candidate gene for developmental dyslexia. PLoS Genet 2005; 1 (04) e50.
  • 49 Luciano M. et al. A haplotype spanning KIAA0319 and TTRAP is associated with normal variation in reading and spelling ability. Biological psychiatry 2007; 62: 811-7.
  • 50 Harold D. et al. Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia. Molecular psychiatry 2006; 11 (12) 1085-91.
  • 51 Couto JM. et al. The KIAA0319-like (KIAA0319L) gene on chromosome 1p34 as a candidate for reading disabilities. J Neurogenetics 2008; 22: 295-313.
  • 52 Pagnamenta AT. et al. Characterization of a family with rare deletions in CNTNAP5 and DOCK4 suggests novel risk loci for autism and dyslexia. Biological psychiatry 2010; 68 (04) 320-8.
  • 53 Tapia-Paez I. et al. The complex of TFII-I, PARP1, and SFPQ proteins regulates the DYX1C1 gene implicated in neuronal migration and dyslexia. FASEB J 2008; 22 (08) 3001-9.
  • 54 Laing E. et al. Learning to read in Williams syndrome: looking beneath the surface of atypical reading development. Journal of child psychology and psychiatry, and allied disciplines 2001; 42 (06) 729-39.
  • 55 Taipale M. et al. A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain. PNAS USA 2003; 100 (20) 11553-8.
  • 56 Schulte-Körne G. et al. Evidence for linkage of spelling disability to chromosome 15. American journal of human genetics 1998; 63 (01) 279-82.
  • 57 Meng H. et al. TDT-association analysis of EKN1 and dyslexia in a Colorado twin cohort. Human genetics 2005; 118 (01) 87-90.
  • 58 Marino C. et al. Pleiotropic effects of DCDC2 and DYX1C1 genes on language and mathematics traits in nuclear families of developmental dyslexia. Behav Genet 2011; 41 (01) 67-76.
  • 59 Meng H. et al. DCDC2 is associated with reading disability and modulates neuronal development in the brain. PNAS USA 2005; 102 (47) 17053-8.
  • 60 Smith SD. et al. Specific reading disability: Identification of an inherited form through linkage analysis. Science 1983; 219 4590 1345-7.
  • 61 Schumacher J, Anthoni H, Dahdouh F, König IR, Hillmer AM. et al. Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia. The American Journal of Human Genetics 2006; 78: 11.
  • 62 Meda SA. et al. Polymorphism of DCDC2 reveals differences in cortical morphology of healthy individuals – a preliminary voxel based morphometry study. Brain Imaging and Behavior 2008; 2 (01) 21-6.
  • 63 Ludwig KU. et al. Investigation of the DCDC2 intron 2 deletion/compound short tandem repeat polymorphism in a large German dyslexia sample. Psychiatric Genetics 2008; 18 (06) 310-2.
  • 64 Lind PA. et al. Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample. Eur J Hum Genet 2010; 18 (06) 668-73.
  • 65 Francks C. et al. Familial and genetic effects on motor coordination, laterality, and reading-related cognition. Am J Psychiatry 2003; 160 (11) 1970-7.
  • 66 Anthoni H. et al. A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia. Human Molecular Genetics 2007; 16 (06) 667-77.