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Nuklearmedizin 1995; 34(03): 92-99
DOI: 10.1055/s-0038-1629762
Original Article
Schattauer GmbH

Immunogenic and Non-Immunogenic Hyperthyroidism

Recent Trends in Prealpine Switzerland and in Coastal Poland
Claudine Als
1   From the Departments of Nuclear Medicine, University of Berne, Inselspital, Berne, Switzerland and of the, Szczecin, Poland
,
Maria Listewnik
1   From the Departments of Nuclear Medicine, University of Berne, Inselspital, Berne, Switzerland and of the, Szczecin, Poland
2   From the National Hospital of the Pomeranian Medical Academy, Szczecin, Poland
,
H. Rosier
1   From the Departments of Nuclear Medicine, University of Berne, Inselspital, Berne, Switzerland and of the, Szczecin, Poland
,
Elisabeth Bartkowiak
2   From the National Hospital of the Pomeranian Medical Academy, Szczecin, Poland
› Institutsangaben
Weitere Informationen

Publikationsverlauf

Received: 21. Oktober 1994

in revised form: 05. Dezember 1994

Publikationsdatum:
03. Februar 2018 (online)

    Lizenzen und Reprints

Summary

Annual occurrences of immunogenic (IH) and non-immunogenic hyperthyroidism (NIH) between Berne (1976, 1982, 1991) and Szczecin (1973, 1980, 1991) were compared. Out of 21,025 patients referred for thyroid examinations, 10.1% (average) were hyperthyroid. In Berne (former endemic goiter region) and Szczecin (without goiter endemicity) IH occurred in 41% and 68%, NIH in 59% and 32% of hyperthyroid patients, respectively. Within a stable incidence of NIH in Berne, toxic adenomas (TA) decreased from 41% (1976) to 17% (1991) (p <0.005). In Szczecin, where iodine deficiency is in an early stage, the TA frequency did not change significantly: from 24% (1973) to 28% (1991). Increases of TA or of multifocal functional autonomy apparently “mark” incipient or, respectively, decreasing deficiencies in nutritious iodine. Hyperthyroid patients in Berne compared to Szczecin were older, both with IH (54 versus 45 y) and NIH (65 versus 52 y). Age at diagnosis was stable in Berne but increasing (p <0.05) in Szczecin (from 43 to 52 y).

Zusammenfassung

Immunogene (IH) und nichtimmunogene (NIH) Hyperthyreosen wurden zwischen Bern (Strumaendemie: 1976, 1982, 1991) und Szczecin (keine Struma-endemie: 1973, 1980, 1991) verglichen. Von 21025 für Schilddrüsenuntersuchungen zugewiesenen Patienten waren 10,1% hyperthyreot. In Bern und Szczecin war die IH mit 41 und 68%, die NIH mit 59 und 32% vertreten. Innerhalb einer stabilen NIH-Häufigkeit in Bern nahm das toxische Adenom (TA) von 41 % (1976) auf 17% (1991) (p <0,005) ab. Bei neu aufgetretenem Jodmangel in Szczecin veränderte sich die TA-Häufigkeit nicht signifikant: von 24% (1973) auf 28% (1991). Häufigkeitszunahmen von TA und multifokaler funktioneller Autonomie scheinen die anlaufende oder rückgänge Jodzufuhr zu begleiten. Hyperthyreote Patienten in Bern waren durchschnittlich älter als in Szczecin: mit IH 54 gegen 45 a, mit NIH 65 gegen 52 a. Das Alter bei Diagnosestellung war in Bern konstant, in Szczecin stieg es jedoch an (von 43 auf 52 a, p <0,05).

Keywords

Hyperthyroidism - iodine deficiency epidemiology - multinodular toxic goiter

Schlüsselwörter

Hyperthyreose - Jodmangel - Epidemiologie - Schilddrüsenautonomie
 

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