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Nuklearmedizin 1998; 37(04): 141-145
DOI: 10.1055/s-0038-1632314
Original Article
Schattauer GmbH

Adrenocortical Scintigraphy with 131I-6-Beta-Iodomethyl-NorchoIesterol (NP 59) in Bilateral Adrenocortical Carcinoma

Nebennierenrinden-Szintigraphie mit 131I-6-Beta-Iodomethyl-Norcholesterol (NP 59) bei Nebennierenrinden-Karzinom
Gloria Ruíz Hernández
1   Servei de Medicina Nuclear
,
F. J. C. Pallarés
1   Servei de Medicina Nuclear
,
A. R. Bartual
2   Servei d’Endocrinología, Hospital Clínic Universitari de València, Spain
,
Susana Tenes Rodrigo
2   Servei d’Endocrinología, Hospital Clínic Universitari de València, Spain
,
F. J. Ampudia-Blasco
2   Servei d’Endocrinología, Hospital Clínic Universitari de València, Spain
,
C. R. de Ávila y Ávalos
1   Servei de Medicina Nuclear
› Author Affiliations
Further Information

Publication History

received: 27 May 1997

Accepted after major revision 05 December 1997

Publication Date:
03 February 2018 (online)

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Summary

A case of a 49-year-old man suffering from bilateral adrenocortical carcinoma with local and secondary rapid progression is reported. The results of adrenocortical scintigraphy (NP 59) and histological findings allowed the diagnosis. This case report and a literature review showed the importance of using adrenocortical scintigraphy as a complementary imaging procedure of CT or MR images.

Zusammenfassung

Es wird über einen 49jährigen Mann berichtet, der an einem beidseitigen Nebenierenrinden-Karzinom mit schneller lokaler und sekundärer Progression leidet. Die Ergebnisse der Nebenierenrinden-Szintigraphie (NP 59) und Histologie ermöglichten die Diagnose. Dieser Fallbericht und ein Literaturüberblick zeigen die Bedeutung der Nebenierenrinden- Szintigraphie als ein zusätzliches bildgebendes Verfahren neben CT und NMR.

Keywords

Bilateral incidentaloma - adrenocortical scintigraphy (NP 59) - adrenocortical carcinoma

Schlüsselwörter

Beidseitiges Inzidentalom - Nebenierenrinden-Szintigraphie (NP 59) - Nebenierenrinden-Karzinom
 

  • References

  • 1 Dunnick NR. Hanson lecture. Adrenal imaging: current status. AJR – Am J Roentgenol 1990; 154: 927-36.
    PubMedGoogle Scholar
  • 2 Francis IR, Gross MD, Shapiro B, Krobkin M, Quint LE. Integrated imaging of adrenal disease. Radiology 1992; 184: 1-13.
    CrossrefPubMedGoogle Scholar
  • 3 Chao CS, Zhou ZG, Liao EY. The diagnosis and management of adrenal “incidentalo- ma”. Chung Hua Nei Ko Tsa Chih 1994; 33: 395-7.
    PubMedGoogle Scholar
  • 4 Gross MD, Shapiro B, Bouffard JA, Glazer GM, Francis IR, Wilton GP. et al. Distinguishing benign from malignant euadrenal masses. Rev. Ann Intern Med 1988; 109: 613-8.
    Google Scholar
  • 5 Shapiro B, Fig LM, Gross MD, Khafagi F. Radiochemical diagnosis of adrenal disease. Crit Rev Clin Lab Sei 1989; 27: 265-98.
    Google Scholar
  • 6 Francis IR, Smid A, Gross MD, Shapiro B, Naylor B, Glazer GM. Adrenal masses in oncologic patients: functional and morphologic evaluation. Radiology 1988; 166: 353-6.
    CrossrefPubMedGoogle Scholar
  • 7 Gross MD, Wilton GP, Shapiro B, Cho K, Samuels BI, Bouffard JA. et al. Functional and scintigraphic evaluation of the silent adrenal mass. J Nucl Med 1987; 28: 1401-7.
    PubMedGoogle Scholar
  • 8 Ogita M, Oyama T, Onohara S, Nakabeppu Y, Mukai H, Abeyama K. et al. Magnetic resonance imaging of the adrenal gland. Nippon – Igaku – Hoshasen – Gakkai – Zasshi 1991; 51: 1431-41.
    PubMedGoogle Scholar
  • 9 Ho YJ, Yang CF, Lee SK, Chen JH, Hung SW, Lee KR. MRI of adrenal tumors. Chung – Hua. I – Hsueh – Tsa – Chih – Taipei 1992; 49: 231-7.
    PubMedGoogle Scholar
  • 10 Honda H, Onitsuka H, Naitou S, Murakami J, Araki A, Torii Y. et al. Role of MRI in diagnosis of adrenal tumors. Nippin – Igaku – Hoshasen – Gakkai – Zasshi 1991; 51: 617-25.
    Google Scholar
  • 11 Gross MD, Shapiro B. Clinical review 50: clinically silent adrenal masses. J Clin Endocrinol Metab 1993; 77: 885-8.
    PubMedGoogle Scholar
  • 12 Kao CH, Liao SQ, Wang SJ, Lin MS, Hsu CY, Lin WY. 131I NP-59 adrenal cortical scintigraphy in suspected primary aldosteronism. Kao – Hsiung – I – Hsueh – Ko – Hsueh – Tsa – Chih 1992; 8: 213-8.
    PubMedGoogle Scholar
  • 13 Kazerooni EA, Sisson JC, Shapiro B, Gross MD, Driedger A, Hurwitz GA. et al. Diagnostic accuracy and pitfalls of (iodine-131) 6-beta-iodomethyl-19-norcho- lesterol (NP-59) imaging. J Nucl Med 1990; 31: 526-34.
    PubMedGoogle Scholar
  • 14 Nakajo M, Nakabeppu Y, Yonekura R, Iwashita S, Goto T. The role of adrenocortical scintigraphy in the evaluation of unilateral incidentally discovered adrenal and juxta- adrenal masses. Ann Nucl Med 1993; 7: 157-66.
    CrossrefPubMedGoogle Scholar
  • 15 Ishimura J, Kawanaka M, Fukuchi M. Clinical application of SPECT in adrenal imaging with iodine-131 -6-beta-iodomethyl-19-norcholesterol. Clin Nucl Med 1989; 14: 278-81.
    CrossrefPubMedGoogle Scholar
  • 16 Tenenbaum F, Lumbroso J, Schlumberger M, Mure A, Plouin PF, Caillou B. et al. Comparison of radiolabeled octeotride and metaiodobenzylguanidine (MIBG) scintigraphy in malignant pheochromocytoma. J Nucl Med 1995; 36: 1-6.
    PubMedGoogle Scholar
  • 17 Neumann DR, Basile KE, Bravo EL, Chen EQ, Go RT. Malignant pheochromocytoma of the anterior mediastinum: PET findings with (18F) FDG and 82 Rb. J Comput Assist Tomogr 1996; 20: 312-6.
    CrossrefPubMedGoogle Scholar
  • 18 Shulkin BL, Koeppe RA, Francis IR, Deeb GM, Lloyd RV, Thompson NW. Pheochromocytomas that do not accumulate metaiodobenzylguanidine: localization with PET and administration of FDG. Radiology 1993; 186: 711-5.
    CrossrefPubMedGoogle Scholar
  • 19 Shulkin BL, Wieland DM, Schwaiger M, Thompson NW, Francis IR, Haka MS. et al. PET scanning with hydroxyephedrine: an approach to the localization of pheochromocytoma. J Nucl Med 1992; 33: 1125-31.
    PubMedGoogle Scholar
  • 20 Gross MD, Shapiro B, Francis IR, Bree RL, Korobkin M, McLeod MK. et al. Scintigraphy of incidentally discovered bilateral adrenal masses. Eur J Nucl Med 1995; 22: 315-21.
    CrossrefPubMedGoogle Scholar